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Eva Särndahl

Befattning: Professor Organisation: Institutionen för medicinska vetenskaper

E-post: ZXZhLnNhcm5kYWhsO29ydS5zZQ==

Telefon: 019 303684

Rum: X2105

Forskningsämne

Forskningsmiljöer

Responsive Nutrition Research Centre

Om Eva Särndahl

Research

The Role of Inflammasome Signaling in Health and Disease

Eva Särndahl is professor in Medical microbiology at Örebro University in Sweden. She has more than 25 years of experience in signal transduction involved in the regulation of the inflammatory process both in keeping immunological homeostasis but also during the development of inflammatory-mediated diseases. During the last seven years, the focus has been set on the involvement of inflammasome signaling in health and disease. Especially the role of dysregulated signaling due to variations in genes encoding the NLRP3 inflammasome in order to understand the inter-individual differences that determine why some individuals respond with severe, life-threatening inflammation, whereas others display a quiescent progression, or even remain asymptomatic following microbial challenge. Currently, this is investigated in patients with sepsis induced by S. aureus, E. coli and N. meningitides as well as in the development of type 2-diabetes and cardiovascular disease.

Besides its role in sensing microbes and their pathogen-associated molecular patterns (PAMPs), the NLRP3 inflammasome detects danger-associated molecular patterns (DAMPs), like nano particles, asbestos and silica but also endogenous substances. In collaboration, the underlying mechanisms in host innate response to stimuli and stressors are investigated in order to understand inflammatory-mediated diseases, including cystic fibrosis, auto-inflammatory/autoimmune diseases, inflammation developed in foundry workers and surgery-induced inflammation.

Short Career Narrative

I defended my thesis at Linköping University in 1994. My thesis revealed that chemotactic receptors are turned off by a lateral segregation between the receptor and its transducing partner, i.e. the G-protein; data that also suggests the cytoskeleton to function as a scaffold for signal transduction. Two years later I started my own research group studying the involvement of pro vs. anti-inflammatory signaling on leukocyte adhesion in order to understand the progression of inflammation and its resolution. During this time, I was the recipient of the Swedish Cancer Society 2-year postdoc position in 1995, and a 4-year Assisting Professorship by the Swedish Medical Research Council in 1998. In 2000-01, I was a Fulbright Scholar in Dr. Charles Serhan's laboratory at Harvard Medical School, USA studying and acquiring knowledge on the anti-inflammatory eicosanoid lipoxin. This work was awarded the national Crafoord research grant from the Royal Swedish Academy of Sciences.

In 2005, I was asked to join a project in which a rheumatologists and a geneticist needed help to understand the inflammatory mechanisms of a patient with auto-inflammatory symptoms. Polymorphisms of the NLRP3 inflammasome in combination with C10X in CARD8 were found to create an over-activated inflammasome resulting in elevated IL-1β production; thereby giving the patient his symptoms (Verma et al. 2008). The interest for inflammasome signaling was thereby uncovered, and has since been the main focus of my research. In 2007, got a professorship at Örebro University, and our research has been recognized by national founding as well as strategically research grants and positions from Örebro University. In 2013, the collaborative network “iRiSC - Inflammatory Response and Infection Susceptibility Centre” involving national and international researchers was launched with me as its Director. Read more about iRiSC.

Pågående projekt

Avslutade projekt

Forskargrupper

Inflammatory Response and Infection Susceptibility Centre (iRiSC)

Publikationer

Artiklar i tidskrifter | Artiklar, forskningsöversikter | Konferensbidrag | Manuskript |

Artiklar i tidskrifter

Belayneh, M. , Mengesha, M. , Idosa, B. A. , Fentaw, S. , Moges, B. , Tazu, Z. , Assefa, M. , Garpenholt, Ö. & et al. (2024). CARD8 polymorphisms among bacterial meningitis patients in North-West Ethiopia. BMC Infectious Diseases, 24 (1). [BibTeX]
Alijagic, A. , Wang, X. , Vallabani, N. V. S. , Melin, P. , Särndahl, E. , Karlsson, H. L. & Odnevall, I. (2024). Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders. Nano Select, 5 (4). [BibTeX]
Salihovic, S. , Eklund, D. , Kruse, R. , Wallgren, U. , Hyötyläinen, T. , Särndahl, E. & Kurland, L. (2024). Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance. Metabolomics, 20 (5). [BibTeX]
Herring, M. , Persson, A. , Potter, R. , Karlsson, R. , Särndahl, E. & Ejdebäck, M. (2024). Exposing kinetic disparities between inflammasome readouts using time-resolved analysis. Heliyon, 10 (11). [BibTeX]
Alijagic, A. , Kotlyar, O. , Larsson, M. , Salihovic, S. , Hedbrant, A. , Eriksson, U. , Karlsson, P. , Persson, A. & et al. (2024). Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environment International, 183. [BibTeX]
Krantz, M. , Eklund, D. , Särndahl, E. & Hedbrant, A. (2023). A detailed molecular network map and model of the NLRP3 inflammasome. Frontiers in Immunology, 14. [BibTeX]
Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2). [BibTeX]
Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. , Salihovic, S. & Eklund, D. (2023). Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders. BMC Psychiatry, 23 (1). [BibTeX]
Baban, B. , Eklund, D. , Tuerxun, K. , Alshamari, M. , Laviano, A. , Ljungqvist, O. & Särndahl, E. (2023). Altered insulin sensitivity and immune function in patients with colorectal cancer. Clinical Nutrition ESPEN, 58, 193-200. [BibTeX]
Nikaein, N. , Tuerxun, K. , Cedersund, G. , Eklund, D. , Kruse, R. , Särndahl, E. , Nånberg, E. , Thonig, A. & et al. (2023). Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation. Journal of Biological Chemistry, 299 (10). [BibTeX]
Hedbrant, A. , Engström, C. , Andersson, L. , Eklund, D. , Westberg, H. , Persson, A. & Särndahl, E. (2023). Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease. Environmental Health, 22 (1). [BibTeX]
Tuerxun, K. , Eklund, D. , Wallgren, U. , Dannenberg, K. , Repsilber, D. , Kruse, R. , Särndahl, E. & Kurland, L. (2023). Predicting sepsis using a combination of clinical information and molecular immune markers sampled in the ambulance. Scientific Reports, 13 (1). [BibTeX]
Säll, O. , Eriksson, L. , Idosa Berhane, A. , Persson, A. , Magnuson, A. , Thulin Hedberg, S. , Sundqvist, M. , Per, O. & et al. (2023). Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students. Epidemiology and Infection, 151. [BibTeX]
Andersson, L. , Hedbrant, A. , Bryngelsson, I. , Vihlborg, P. , Särndahl, E. & Westberg, H. (2023). Silica Exposure and Cardiovascular, Cerebrovascular, and Respiratory Morbidity in a Cohort of Male Swedish Iron Foundry Workers. Journal of Occupational and Environmental Medicine, 65 (9), 731-739. [BibTeX]
Tuerxun, K. , Midtbö, K. , Särndahl, E. , Vorontsov, E. , Karlsson, R. , Persson, A. , Kruse, R. , Eklund, D. & et al. (2022). Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1. Journal of Leukocyte Biology, 112 (4), 679-692. [BibTeX]
Hedbrant, A. , Eklund, D. , Andersson, L. , Bryngelsson, I. , Persson, A. , Westberg, H. & Särndahl, E. (2022). Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry. Biomarkers, 60-70. [BibTeX]
Vallabani, N. V. S. , Alijagic, A. , Persson, A. , Odnevall, I. , Särndahl, E. & Karlsson, H. L. (2022). Toxicity evaluation of particles formed during 3D-printing: cytotoxic, genotoxic, and inflammatory response in lung and macrophage models. Toxicology, 467. [BibTeX]
Klasson, M. , Lindberg, M. , Westberg, H. , Bryngelsson, I. , Tuerxun, K. , Persson, A. & Särndahl, E. (2021). Dermal exposure to cobalt studied in vitro in keratinocytes: effects of cobalt exposure on inflammasome activated cytokines, and mRNA response. Biomarkers, 26 (8), 674-684. [BibTeX]
Klasson, M. , Lindberg, M. , Särndahl, E. , Westberg, H. , Bryngelsson, I. , Tuerxun, K. & Persson, A. (2021). Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt: Effects of high and low calcium growth conditions. PLOS ONE, 16 (6). [BibTeX]
Andersson, L. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Sjögren, B. , Stockfelt, L. , Särndahl, E. & Westberg, H. (2021). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in the Swedish hard metal industry, in particular to cobalt. Biomarkers, 26 (6), 557-569. [BibTeX]
Hylén, U. , McGlinchey, A. J. , Oresic, M. , Bejerot, S. , Humble, M. B. , Särndahl, E. , Hyötyläinen, T. & Eklund, D. (2021). Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness. Frontiers in Psychiatry, 12. [BibTeX]
Demirel, I. , Persson, A. , Brauner, A. , Särndahl, E. , Kruse, R. & Persson, K. (2020). Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils. Scientific Reports, 10 (1). [BibTeX]
Hylén, U. , Eklund, D. , Humble, M. B. , Bartoszek, J. , Särndahl, E. & Bejerot, S. (2020). Increased inflammasome activity in markedly ill psychiatric patients: An explorative study. Journal of Neuroimmunology, 339. [BibTeX]
Midtbö, K. , Eklund, D. , Särndahl, E. & Persson, A. (2020). Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1 β and Interleukin-18 from Human Monocytes. Mediators of Inflammation, 2020. [BibTeX]
Hedbrant, A. , Andersson, L. , Bryngelsson, I. , Eklund, D. , Westberg, H. , Särndahl, E. & Persson, A. (2020). Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Mediators of Inflammation. [BibTeX]
Andersson, L. , Hedbrant, A. , Bryngelsson, I. , Persson, A. , Johansson, A. , Ericsson, A. , Vihlborg, P. , Sjögren, B. & et al. (2020). Respiratory Health and Inflammatory Markers: Exposure to Cobalt in the Swedish Hard Metal Industry. Journal of Occupational and Environmental Medicine, 62 (10), 820-829. [BibTeX]
Serhan, C. N. , Gupta, S. K. , Perretti, M. , Godson, C. , Brennan, E. , Li, Y. , Soehnlein, O. , Shimizu, T. & et al. (2020). The Atlas of Inflammation Resolution (AIR). Molecular Aspects of Medicine, 74. [BibTeX]
Rasmussen, G. , Asfaw Idosa, B. , Monecke, S. , Bäckman, A. , Strålin, K. , Särndahl, E. & Söderquist, B. (2019). Caspase-1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteremia. Microbiology and immunology, 63 (12), 487-499. [BibTeX]
Westberg, H. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Johansson, A. , Ericsson, A. , Sjögren, B. , Stockfelt, L. & et al. (2019). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz. International Archives of Occupational and Environmental Health, 92 (8), 1087-1098. [BibTeX]
Asfaw Idosa, B. , Kelly, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Persson, A. (2019). Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research. [BibTeX]
Andersson, L. , Bryngelsson, I. , Hedbrant, A. , Persson, A. , Johansson, A. , Ericsson, A. , Lindell, I. , Stockfelt, L. & et al. (2019). Respiratory health and inflammatory markers: Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries. PLOS ONE, 14 (11). [BibTeX]
Demirel, I. , Persson, A. , Brauner, A. , Särndahl, E. , Kruse, R. & Persson, K. (2018). Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells. Frontiers in Cellular and Infection Microbiology, 8. [BibTeX]
Månsson, E. , Sahdo, B. , Nilsdotter-Augustinsson, Å. , Särndahl, E. & Söderquist, B. (2018). Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals. Journal of bone and joint infection, 3 (1), 10-14. [BibTeX]
Månsson, E. , Söderquist, B. , Nilsdotter-Augustinsson, Å. , Särndahl, E. & Demirel, I. (2018). Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1 release from human neutrophils than isolates from normal flora. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 678-684. [BibTeX]
Bergström, I. , Lundberg, A. K. , Jönsson, S. , Särndahl, E. , Ernerudh, J. & Jonasson, L. (2017). Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity. PLOS ONE, 12 (3). [BibTeX]
Baban, B. , Ljungqvist, O. & Särndahl, E. (2016). Inflammasome activation, colonic cancer and glucose metabolism. Clinical Nutrition ESPEN, 12. [BibTeX]
Hussain, S. , Varelogianni, G. , Särndahl, E. & Roomans, G. M. (2015). N-acetylcysteine and azithromycin affect the innate immune response in cystic fibrosis bronchial epithelial cells in vitro. Experimental Lung Research, 41 (5), 251-260. [BibTeX]
Asfaw Idosa, B. , Sahdo, B. , Balcha, E. , Kelly, A. , Söderquist, B. & Särndahl, E. (2014). C10X polymorphism in the CARD8 gene is associated with bacteraemia. Immunity, inflammation and disease, 2 (1), 13-20. [BibTeX]
Eklund, D. , Welin, A. , Andersson, H. , Verma, D. , Söderkvist, P. , Stendahl, O. , Särndahl, E. & Lerm, M. (2014). Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis. Journal of Infectious Diseases, 209 (5), 749-753. [BibTeX]
Sahdo, B. , Evans, A. L. , Arnemo, J. M. , Fröbert, O. , Särndahl, E. & Blanc, S. (2013). Body temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators?. International Journal of Medical Sciences, 10 (5), 508-514. [BibTeX]
Paramel, G. , Folkersen, L. , Strawbridge, R. J. , Elmabsout, A. , Särndahl, E. , Lundman, P. , Jansson, J. , Hansson, G. K. & et al. (2013). CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clinical Science, 125 (8), 401-407. [BibTeX]
Sahdo, B. , Fransén, K. , Asfaw Idosa, B. , Eriksson, P. , Söderquist, B. , Kelly, A. & Särndahl, E. (2013). Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLOS ONE, 8 (10). [BibTeX]
Sahdo, B. , Särndahl, E. , Elgh, F. & Söderquist, B. (2013). Propionibacterium acnes activates caspase-1 in human neutrophils. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (7), 652-63. [BibTeX]
Blomgran, R. , Patcha Brodin, V. , Verma, D. , Bergström, I. , Söderkvist, P. , Sjöwall, C. , Eriksson, P. , Lerm, M. & et al. (2012). Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils. PLOS ONE, 7 (3). [BibTeX]
Lönn, J. , Starkhammar Johansson, C. , Kälvegren, H. , Brudin, L. , Skoglund, C. , Garvin, P. , Särndahl, E. , Ravald, N. & et al. (2012). Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition. Results in Immunology, 2, 7-12. [BibTeX]
Verma, D. , Särndahl, E. , Andersson, H. , Eriksson, P. , Fredrikson, M. , Jönsson, J. , Lerm, M. & Söderkvist, P. (2012). The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production. PLOS ONE, 7 (4). [BibTeX]
Börgeson, E. , Lönn, J. , Bergström, I. , Brodin, V. P. , Ramström, S. , Nayeri, F. , Särndahl, E. & Bengtsson, T. (2011). Lipoxin A(4) inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. Infection and Immunity, 79 (4), 1489-1497. [BibTeX]
Särndahl, E. , Bergström, I. , Nijm, J. , Forslund, T. , Perretti, M. & Jonasson, L. (2010). Enhanced neutrophil expression of annexin-1 in coronary artery disease. Metabolism: Clinical and Experimental, 59 (3), 433-440. [BibTeX]
Fröbert, O. , Christensen, K. , Fahlman, Å. , Brunberg, S. , Josefsson, J. , Särndahl, E. , Swenson, J. E. & Arnemo, J. M. (2010). Platelet function in brown bear (Ursus arctos) compared to man. Thrombosis Journal, 8, 11. [BibTeX]
Verma, D. , Eriksson, P. , Sahdo, B. , Persson, A. , Ejdeback, M. , Särndahl, E. & Söderkvist, P. (2010). Two adult siblings with atypical Cryopyrin-associated periodic syndrome due to a novel M299V mutation in NLRP3. Arthritis and Rheumatism, 62 (7), 2138-2143. [BibTeX]
Winberg, M. E. , Holm, A. , Särndahl, E. , Vinet, A. F. , Descoteaux, A. , Magnusson, K. , Rasmusson, B. & Lerm, M. (2009). Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts.. Microbes and infection, 11 (2), 215-22. [BibTeX]
Verma, D. , Lerm, M. , Blomgran Julinder, R. , Eriksson, P. , Söderkvist, P. & Särndahl, E. (2008). Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?. Arthritis and Rheumatism, 58 (3), 888-894. [BibTeX]
Welin, A. , Winberg, M. E. , Abdalla, H. , Särndahl, E. , Rasmusson, B. , Stendahl, O. & Lerm, M. (2008). Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block. Infection and Immunity, 76 (7), 2882-7. [BibTeX]
Särndahl, E. , Bergström, I. , Brodin, V. P. , Nijm, J. , Lundqvist Setterud, H. & Jonasson, L. (2007). Neutrophil activation status in stable coronary artery disease. PloS one, 2 (10), e1056. [BibTeX]

Artiklar, forskningsöversikter

Alijagic, A. & Särndahl, E. (2024). Can evolutionary immunology decode micro and nanoplastic challenges?. Frontiers in Immunology, 15. [BibTeX]
Alijagic, A. , Suljević, D. , Fočak, M. , Sulejmanović, J. , Šehović, E. , Särndahl, E. & Engwall, M. (2024). The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective. Environment International, 188. [BibTeX]
Alijagic, A. , Hedbrant, A. , Persson, A. , Larsson, M. , Engwall, M. & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Frontiers in Immunology, 14. [BibTeX]
Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in Toxicology, 4. [BibTeX]

Konferensbidrag

Alijagic, A. , Södergren Seilitz, F. , Bredberg, A. , Hakonen, A. , Larsson, M. , Sjöberg, V. , Kotlyar, O. , Persson, A. & et al. (2024). Comprehensive chemical and toxicological screening of e-waste plastic chemicals. I: Toxicology Letters. Konferensbidrag vid 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, Denmark, September 8-11, 2024. (ss. S66-S66). Elsevier. [BibTeX]
Hedbrant, A. , Engström, C. , Assenhöj, M. , Karlsson, H. , Andersson, L. , Särndahl, E. & Ljunggren, S. (2024). Particle exposure in metal industries and its impact on biomarkers, indicate effects on several biological systems. I: Toxicology Letters. Konferensbidrag vid 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, Denmark, September 8-11, 2024. (ss. S343-S343). Elsevier. [BibTeX]
Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. I: Toxicology Letters. Konferensbidrag vid XVIth International Congress of Toxicology (ICT 2022) - UNITING IN TOXICOLOGY, Maastricht, The Netherlands, September 18-21, 2022. (ss. S226-S227). Elsevier. [BibTeX]

Manuskript

Herring, M. , Persson, A. , Karlsson, R. , Repsilber, D. , Ejdebäck, M. , Särndahl, E. , Nikaein, N. & Kotlyar, O. Analysis of NLRP3 trigger-dependency on ASC-speck formation and lifetime. [BibTeX]
Asfaw Idosa, B. , Sahdo, B. , Balcha, E. , Kelly, A. , Söderquist, B. & Särndahl, E. C10X polymorphism in the CARD8 gene is associated with bacteraemia. [BibTeX]
Rasmussen, G. , Asfaw Idosa, B. , Bäckman, A. , Monecke, S. , Strålin, K. , Särndahl, E. & Söderquist, B. Caspase-1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteraemia. [BibTeX]
Sahdo, B. , Fransén, K. , Idosa, B. A. , Eriksson, P. , Söderquist, B. , Kelly, A. & Särndahl, E. Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the nlrp3 inflammasome. [BibTeX]
Varelogianni, G. , Strid, H. , Särndahl, E. , Björkqvist, M. & Roomans, G. M. Decreased expression of Nod2-receptors and production of pro-inflammatory cytokines in cystic fibrosis airway epithelial cells. [BibTeX]
Klasson, M. , Lindberg, M. , Westberg, H. , Bryngelsson, I. , Tuerxun, K. , Persson, A. & Särndahl, E. Dermal exposure to cobalt : possible effects of cobalt exposure on inflammasome, cytokine and mRNA response studied in vitro in keratinocytes. [BibTeX]
Klasson, M. , Lindberg, M. , Särndahl, E. , Bryngelsson, I. & Persson, A. Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt : Effects of high and low calcium growth conditions. [BibTeX]
Baban, B. , Eklund, D. , Tuerxun, K. , Matthiessen, P. , Särndahl, E. & Ljungqvist, O. Dynamics of inflammation and inflammasome activation in open versus minimally invasive colorectal surgery for cancer. [BibTeX]
Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. , Eklund, D. & Salihovic, S. Elevated plasma levels of polyamines and kynurenines in individuals with psychiatric disorders. [BibTeX]
Herring, M. , Särndahl, E. , Kotlyar, O. , Scherbak, N. , Engwall, M. , Karlsson, R. , Ejdebäck, M. , Persson, A. & et al. Exploring NLRP3-related phenotypic fingerprints in human macrophages using Cell Painting assay. [BibTeX]
Asfaw Idosa, B. , Jacobsson, S. , Kelly, A. , Fredlund, H. , Persson, A. & Särndahl, E. Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitidis-induced IL-1β and IL-18. [BibTeX]
Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. & Salihovic, S. Individuals with severe psychiatric disorders display altered pattern of plasma immunometabolites. [BibTeX]
Tuerxun, K. , Kurland, L. , Särndahl, E. , Wallgren, U. , Eklund, D. & Kruse, R. Inflammatory imbalance in ambulance patients is associated with sepsis and septic shock. [BibTeX]
Baban, B. , Eklund, D. , Tuerxun, K. , Särndahl, E. & Ljungqvist, O. Insulin resistance and inflammation in open versus minimally invasive colorectal cancer surgery in ERAS. [BibTeX]
Asfaw Idosa, B. , Persson, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Kelly, A. LOS-dependent Neisseria meningitidis-induced caspase-1 activation in human neutrophils. [BibTeX]
Säll, O. , Eriksson, L. , Asfaw, B. , Persson, A. , Magnusson, A. , Thulin Hedberg, S. , Sundqvist, M. , Olcén, P. & et al. Prevalence and persistence of Neisseria meningitidis carriage in Swedish university students. [BibTeX]
Sahdo, B. , DeLeo, F. R. , Söderqvist, B. & Särndahl, E. Staphylococcus aureus-mediated caspase-1 activation in human neutrophils : a role for Panton-Valentine Leukocidin?. [BibTeX]