Maria Larsson
Position: Researcher School/office: School of Science and TechnologyEmail: bWFyaWEubGFyc3NvbjtvcnUuc2U=
Phone: +46 19 301370
Room: B3313
About Maria Larsson
My research area is environmental chemistry focusing on identification, exposure and receptor-mediated mixture effects (cocktail effects) of organic pollutants in complex mixtures. I am using an effect-directed analysis (EDA) approach, combining GC/MS and LC/MS analysis, and mechanism-specific bioreporter assays and high-resolution fractionation techniques for chemical and toxicological characterization and identification of key toxicants in complex mixtures, like soil, air and dust. Special focus is on polycyclic aromatic compounds.
I am the lab director of the bioanalytical laboratory in the Environment and Health group at MTM Research Centre.
Research projects
Active projects
- BALANCE - Treatment of low-contaminated soil with biochar produced from organic waste for sustainable resource use and circular economy
- Effect-based strategy for identification and assessment of potential health effects of hazardous organic chemicals in indoor environments
- Fish & Cocktails
- Identifiera: Identification of toxicity driving polycyclic aromatic compounds (PAC s) for improving environmental risk assessment of contaminated sites
- Mixture-Risk
- NanoSafety2
- PAC-Risk
- PFAS-Risk
- Screening of microplastics and streamlined risk assessment of hazardous substances in sludge using effect driven analysis for a safe recycling on arable lands
- SEASON - Seasonal variation of the fate, availability, and toxicity of priority pollutants at the sediment-water-interface
- The status of ecosystem functions of polluted lands assessed in situ using plant, soil and microbial indicators
- Biochar application for pollutant stabilization and ecological restoration of contaminated land in Sweden
- Ensuring Sustainable Substitution: Learning from the corporate phase-out of PFAS in outdoor clothing
Completed projects
- APPLICERA: Applicable site-specific environmental risk assessment of contaminated soils
- Bioanalytical screening of POPs in otters
- Bioanalytical studies of soils and sediments
- Biokol - Från organiskt avfall till resurs för nyttiggörande av jordavfall
- Chemical and toxicological characterisation of PAHs and related compounds in road dust
- EPHEMARE - Ecotoxicological effects of microplastics in marine ecosystems
- NanoSafety1
- Environmental and health effects of fire fighting foams
- SOILEFFECT: Development of bioreporter-based survey and health risk assessment of toxic chemicals in contaminated areas
- SOILTOX: processoptimering och innovation av marksaneringsmetoder med hjälp av bioanalytiska toxicitetstester
Research groups
Publications
Articles in journals
- Nilén, G. , Larsson, M. , Hyötyläinen, T. & Keiter, S. (2024). A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays. Science of the Total Environment, 906. [BibTeX]
- Drenning, P. , Volchko, Y. , Enell, A. , Berggren Kleja, D. , Larsson, M. & Norrman, J. (2024). A method for evaluating the effects of gentle remediation options (GRO) on soil health: Demonstration at a DDX-contaminated tree nursery in Sweden: Demonstration at a DDX-contaminated tree nursery in Sweden. Science of the Total Environment, 948. [BibTeX]
- Rijk, I. , Ekblad, A. , Dahlin, A. S. , Enell, A. , Larsson, M. , Leroy, P. , Kleja, D. B. , Tiberg, C. & et al. (2024). Biochar and peat amendments affect nitrogen retention, microbial capacity and nitrogen cycling microbial communities in a metal and polycyclic aromatic hydrocarbon contaminated urban soil. Science of the Total Environment, 936. [BibTeX]
- Le Du-Carrée, J. , Palacios, C. K. , Rotander, A. , Larsson, M. , Alijagic, A. , Kotlyar, O. , Engwall, M. , Sjöberg, V. & et al. (2024). Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis. Journal of Hazardous Materials, 471. [BibTeX]
- Rist, S. , Rask, S. , Ntinou, I. V. , Varpe, Ø. , Lindegren, M. , Ugwu, K. , Larsson, M. , Sjöberg, V. & et al. (2024). Cumulative Impacts of Oil Pollution, Ocean Warming, and Coastal Freshening on the Feeding of Arctic Copepods. Environmental Science and Technology, 58 (7), 3163-3172. [BibTeX]
- Alijagic, A. , Kotlyar, O. , Larsson, M. , Salihovic, S. , Hedbrant, A. , Eriksson, U. , Karlsson, P. , Persson, A. & et al. (2024). Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environment International, 183. [BibTeX]
- Behnisch, P. , Besselink, H. , Suzuki, G. , Buchinger, S. , Reifferscheid, G. , Lukas, M. , Wollenweber, M. , Wollenweber, S. & et al. (2024). Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay. Science of the Total Environment, 920. [BibTeX]
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2). [BibTeX]
- Sjöström, Y. , Hagström, K. , Lindh, C. , Bryngelsson, I. , Larsson, M. & Hagberg, J. (2023). Exposure to phthalates and DiNCH among preschool children in Sweden: Urinary metabolite concentrations and predictors of exposure. International journal of hygiene and environmental health, 250. [BibTeX]
- Eriksson, U. , Titaley, I. A. , Engwall, M. & Larsson, M. (2022). Examination of aryl hydrocarbon receptor (AhR), estrogenic and anti-androgenic activities, and levels of polyaromatic compounds (PACs) in tire granulates using in vitro bioassays and chemical analysis. Chemosphere, 298. [BibTeX]
- Titaley, I. A. , Delgado Trine, L. S. , Wang, T. , Duberg, D. , Davis, E. L. , Engwall, M. , Massey Simonich, S. L. & Larsson, M. (2022). Extensive chemical and bioassay analysis of polycyclic aromatic compounds in a creosote-contaminated superfund soil following steam enhanced extraction. Environmental Pollution, 312. [BibTeX]
- Nilén, G. , Obamwonyi, O. S. , Liem-Nguyen, V. , Engwall, M. , Larsson, M. & Keiter, S. (2022). Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio). Aquatic Toxicology, 248. [BibTeX]
- Titaley, I. , Lam, M. M. , Bülow, R. , Enell, A. , Wiberg, K. & Larsson, M. (2021). Characterization of polycyclic aromatic compounds in historically contaminated soil by targeted and non-targeted chemical analysis combined with in vitro bioassay. Environmental Pollution, 289. [BibTeX]
- Cormier, B. , Le Bihanic, F. , Cabar, M. , Crebassa, J. , Blanc, M. , Larsson, M. , Dubocq, F. , Yeung, L. W. Y. & et al. (2021). Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish. Journal of Hazardous Materials, 415. [BibTeX]
- Volchko, Y. , Berggren Kleja, D. , Back, P. , Tiberg, C. , Enell, A. , Larsson, M. , Jones, C. M. , Taylor, A. & et al. (2020). Assessing costs and benefits of improved soil quality management in remediation projects: A study of an urban site contaminated with PAH and metals. Science of the Total Environment, 707. [BibTeX]
- Titaley, I. A. , Eriksson, U. & Larsson, M. (2020). Rapid extraction method of polycyclic aromatic compounds in soil using basic silica selective pressurized liquid extraction. Journal of Chromatography A, 1618. [BibTeX]
- Titaley, I. , Massey Simonich, S. L. & Larsson, M. (2020). Recent Advances in the Study of the Remediation of Polycyclic Aromatic Compound (PAC)-Contaminated Soils: Transformation Products, Toxicity, and Bioavailability Analyses. Environmental Science and Technology Letters, 7 (12), 873-882. [BibTeX]
- Schönlau, C. , Larsson, M. , Lam, M. M. , Engwall, M. , Giesy, J. P. , Rochman, C. & Kärrman, A. (2019). Aryl hydrocarbon receptor-mediated potencies in field-deployed plastics vary by type of polymer. Environmental Science and Pollution Research, 26 (9), 9097-9088. [BibTeX]
- Meyer-Alert, H. , Larsson, M. , Hollert, H. & Keiter, S. (2019). Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio). Ecotoxicology and Environmental Safety, 183. [BibTeX]
- Schönlau, C. , Larsson, M. , Dubocq, F. , Rotander, A. , Van der Zande, R. , Engwall, M. & Kärrman, A. (2019). Effect-Directed Analysis of Ah Receptor-Mediated Potencies in Microplastics Deployed in a Remote Tropical Marine Environment. Frontiers in Environmental Science, 7. [BibTeX]
- Meyer-Alert, H. , Ladermann, K. , Larsson, M. , Schiwy, S. , Hollert, H. & Keiter, S. H. (2018). A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio). Aquatic Toxicology, 204, 117-129. [BibTeX]
- Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P. & Larsson, M. (2018). Methylated PACs Are More Potent than Their Parent Compounds: A Study on AhR-mediated Activity, Degradability and Mixture Interactions in the H4IIE-luc Assay. Environmental Toxicology and Chemistry, 37 (5), 1409-1419. [BibTeX]
- Lam, M. M. , Engwall, M. , Denison, M. S. & Larsson, M. (2018). Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. Environmental Toxicology and Chemistry, 37 (2), 385-397. [BibTeX]
- Larsson, M. , Lam, M. M. , van Hees, P. , Giesy, J. P. & Engwall, M. (2018). Occurrence and leachability of polycyclic aromatic compounds in contaminated soils: Chemical and bioanalytical characterization. Science of the Total Environment, 622-623, 1476-1484. [BibTeX]
- Hafner, C. , Gartiser, S. , Garcia-Kaeufer, M. , Schiwy, S. , Hercher, C. , Meyer, W. , Achten, C. , Larsson, M. & et al. (2015). Investigations on sediment toxicity of German rivers applying a standardized bioassay battery. Environmental Science and Pollution Research, 22 (21), 16358-16370. [BibTeX]
- Larsson, M. , Giesy, J. P. & Engwall, M. (2014). AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition. Environment International, 73, 94-103. [BibTeX]
- Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2014). An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 21 (9), 6243-6251. [BibTeX]
- Larsson, M. , Hagberg, J. , Giesy, J. P. & Engwall, M. (2014). Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 33 (4), 943-953. [BibTeX]
- Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B. & Engwall, M. (2013). Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils. Environmental Science and Pollution Research, 20 (12), 8511-8520. [BibTeX]
- Buitrago, B. H. , Munoz, P. F. , Ribe, V. , Larsson, M. , Engwall, M. , Wojciechowska, E. & Waara, S. (2013). Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays. Ecotoxicology and Environmental Safety, 97, 255-262. [BibTeX]
- Engwall, M. , Venizelos, N. , Westman, O. , Larsson, M. , Nordén, M. , Hollert, H. & Johansson, J. (2013). Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 20 (3), 1881-1888. [BibTeX]
- Larsson, M. , Orbe, D. & Engwall, M. (2012). Exposure time-dependent effects on the relative potencies and additivity of PAHs in the Ah receptor-based H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 31 (5), 1149-1157. [BibTeX]
Articles, reviews/surveys
- Niarchos, G. , Alygizakis, N. , Carere, M. , Dulio, V. , Engwall, M. , Hyötyläinen, T. , Kallenborn, R. , Karakitsios, S. & et al. (2024). Pioneering an effect-based early warning system for hazardous chemicals in the environment. TrAC. Trends in analytical chemistry, 180. [BibTeX]
- Alijagic, A. , Hedbrant, A. , Persson, A. , Larsson, M. , Engwall, M. & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Frontiers in Immunology, 14. [BibTeX]
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in Toxicology, 4. [BibTeX]
- Lundstedt, S. , Bandowe, B. A. M. , Wilcke, W. , Boll, E. , Christensen, J. H. , Vila, J. , Grifoll, M. , Faure, P. & et al. (2014). First intercomparison study on the analysis of oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) and nitrogen heterocyclic polycyclic aromatic compounds (N-PACs) in contaminated soil. TrAC. Trends in analytical chemistry, 57, 83-92. [BibTeX]
Conference papers
- Alijagic, A. , Södergren Seilitz, F. , Bredberg, A. , Hakonen, A. , Larsson, M. , Sjöberg, V. , Kotlyar, O. , Persson, A. & et al. (2024). Comprehensive chemical and toxicological screening of e-waste plastic chemicals. Paper presented at 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, Denmark, September 8-11, 2024. (pp. S66-S66). Elsevier. [BibTeX]
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. In: Toxicology Letters. Paper presented at XVIth International Congress of Toxicology (ICT 2022) - UNITING IN TOXICOLOGY, Maastricht, The Netherlands, September 18-21, 2022. (pp. S226-S227). Elsevier. [BibTeX]
- Larsson, M. , Orbe, D. & Engwall, M. (2012). Ah receptor activating capacity of polycyclic aromatic hydrocarbon derivatives. In: Toxicology Letters. Elsevier. [BibTeX]
- Westman, O. , Nordén, M. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2012). Reduced beta-oxidation in avian following exposure of polycyclic aromatic hydrocarbons. In: Toxicology Letters. Elsevier. [BibTeX]
Doctoral theses, comprehensive summaries
- Larsson, M. (2013). Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro universitet. [BibTeX]
Manuscripts
- Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. An oxygenated metabolite of benzo[a]pyrene increases hepatic β-oxidation of fatty acids in chick embryos. [BibTeX]
- Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B. & Engwall, M. Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils. [BibTeX]
- Westman, O. , Larsson, M. , Hollert, H. & Engwall, M. Comparative study and characterization of mutagenicity and AhR-agonistic potency of contaminated soil, remediated soil, urban city soil and rural soil. [BibTeX]
- Larsson, M. , Giesy, J. P. & Engwall, M. Concentration-addition in risk assessment : prediction of potential AhR-mediated activity in multiple polycyclic aromatic compound (PAC) mixtures. [BibTeX]
- Sjöström, Y. , Holmes, B. , Ricklund, N. , Struwe, N. , Hagström, K. , Hagberg, J. & Larsson, M. Endocrine activities of dust in children's indoor environments : Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment. [BibTeX]
- Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P. & Larsson, M. Methylated PACs are more potent than their parent compounds : a study on AhR-mediated activity, degradability and mixture interactions in the H4IIE-luc assay. [BibTeX]
- Lam, M. M. , Engwall, M. , Denison, M. S. , Giesy, J. P. & Larsson, M. Polyoxymethylene (POM) is a suitable tool for effect-based hazard assessment of PAC-contaminated soil. [BibTeX]
- Schönlau, C. , Holmes, B. , Larsson, M. , Engwall, M. & Kärrman, A. Screening for bioactivities in three types of microplastics deployed in Swedish aquatic environments using a battery of reporter gene assays. [BibTeX]
- Rijk, I. , Ekblad, A. , Dahlin, A. S. , Enell, A. , Larsson, M. , Leroy, P. , Berggren Kleja, D. , Tiberg, C. & et al. The effects of biochar and peat amendment on the nitrogen cycle in a metal- and PAH-contaminated urban soil : results from a field trial. [BibTeX]
- Larsson, M. , Hagberg, J. , Giesy, J. P. & Engwall, M. Time-dependent relative potency factors (REPS) for polycyclic aromatic hydrocarbons and their derivatives in the h4iie-luc. [BibTeX]
Reports
- Kärrman, A. , Bjurlid, F. , Hagberg, J. , Ricklund, N. , Larsson, M. , Stubleski, J. & Hollert, H. (2016). Study of environmental and human health impacts of firefighting agents: A technical report. Örebro, Sweden: Örebro University. [BibTeX]
- Engwall, M. & Larsson, M. (2009). Bioanalys av organiska föroreningars biotillgänglighet: tillämpning i sanerade massor. Stockholm: Naturvårdsverket (Rapport 5931). [BibTeX]