Maria Larsson
Befattning: Forskare Organisation: Institutionen för naturvetenskap och teknikE-post: bWFyaWEubGFyc3NvbjtvcnUuc2U=
Telefon: 019 301370
Rum: B3313
Om Maria Larsson
Bakgrund
Maria Larsson har doktorerat vid MTM i miljökemi med avhandlingen: Chemical and bioanalytical characterisation of PAH-contaminated soils-identification, availability and mixture toxicity of AhR agonists (2013). Arbetar idag som forskare i gruppen för Miljö och Hälsa.
Forskningsinriktning
Mitt forskningsområde är miljökemi med fokus på identifiering, exponering samt kombinationseffekter (cocktail effekter) av organiska föroreningar i komplexa blandningar. Jag använder en effektdriven analys (EDA) som kombinerar kemisk analys och mekanismspecifika bioanalyser med högupplösta fraktioneringstekniker för kemisk och toxikologisk karakterisering och identifiering av organiska föroreningar och deras toxiska mekanismer i komplexa blandningar som luft, damm och jord. Särskilt fokus är på polycykliska aromatiska föreningar.
Jag är labchef för det bioanalytiska laboratoriet i gruppen för Miljö och Hälsa vid MTM forskningscentrum.
Forskningsprojekt
Pågående projekt
- BALANCE - Behandling av lågförorenad jord med biokol tillverkad av organiskt avfall för hållbar resursanvändning och cirkulär ekonomi
- Effektbaserad strategi för identifiering och bedömning av potentiella hälsoeffekter av farliga organiska kemikalier i inomhusmiljöer
- Fish & Cocktails
- Identifiera: Identifiering av miljö- och hälsoskadliga polycykliska aromatiska ämnen (PAC) för en förbättrad riskbedömning av förorenade områden
- Mixture-Risk
- NanoSafety2
- PAC-Risk
- PFAS-Risk
- Screening av mikroplaster och effektbaserad riskbedömning av kemikalier i avloppsslam för säkrare återanvändning inom jordbruket
- SEASON - Säsongsvariationers betydelse för distribution, tillgänglighet och toxicitet för kemiska föroreningar vid gränsytan mellan sediment och vatten
- Statusen hos ekosystemfunktioner i förorenade marker utvärderade in situ med hjälp av växt- och mikrobindikatorer
- Tillsats av biokol för stabilisering av föroreningar och ekologisk restaurering av marken
- Utfasningen av PFAS i friluftskläder, hur miljövänlig är den?
Avslutade projekt
- APPLICERA: Applicable site-specific environmental risk assessment of contaminated soils
- Bioanalytical screening of POPs in otters
- Bioanalytical studies of soils and sediments
- Biokol - Från organiskt avfall till resurs för nyttiggörande av jordavfall
- Chemical and toxicological characterisation of PAHs and related compounds in road dust
- EPHEMARE - Ecotoxicological effects of microplastics in marine ecosystems
- NanoSafety1
- Släckvätskors miljö- och hälsopåverkan
- SOILEFFECT: Development of bioreporter-based survey and health risk assessment of toxic chemicals in contaminated areas
- SOILTOX: processoptimering och innovation av marksaneringsmetoder med hjälp av bioanalytiska toxicitetstester
Forskargrupper
Publikationer
Artiklar i tidskrifter
- Nilén, G. , Larsson, M. , Hyötyläinen, T. & Keiter, S. (2024). A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays. Science of the Total Environment, 906. [BibTeX]
- Drenning, P. , Volchko, Y. , Enell, A. , Berggren Kleja, D. , Larsson, M. & Norrman, J. (2024). A method for evaluating the effects of gentle remediation options (GRO) on soil health: Demonstration at a DDX-contaminated tree nursery in Sweden: Demonstration at a DDX-contaminated tree nursery in Sweden. Science of the Total Environment, 948. [BibTeX]
- Rijk, I. , Ekblad, A. , Dahlin, A. S. , Enell, A. , Larsson, M. , Leroy, P. , Kleja, D. B. , Tiberg, C. & et al. (2024). Biochar and peat amendments affect nitrogen retention, microbial capacity and nitrogen cycling microbial communities in a metal and polycyclic aromatic hydrocarbon contaminated urban soil. Science of the Total Environment, 936. [BibTeX]
- Le Du-Carrée, J. , Palacios, C. K. , Rotander, A. , Larsson, M. , Alijagic, A. , Kotlyar, O. , Engwall, M. , Sjöberg, V. & et al. (2024). Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis. Journal of Hazardous Materials, 471. [BibTeX]
- Rist, S. , Rask, S. , Ntinou, I. V. , Varpe, Ø. , Lindegren, M. , Ugwu, K. , Larsson, M. , Sjöberg, V. & et al. (2024). Cumulative Impacts of Oil Pollution, Ocean Warming, and Coastal Freshening on the Feeding of Arctic Copepods. Environmental Science and Technology, 58 (7), 3163-3172. [BibTeX]
- Alijagic, A. , Kotlyar, O. , Larsson, M. , Salihovic, S. , Hedbrant, A. , Eriksson, U. , Karlsson, P. , Persson, A. & et al. (2024). Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environment International, 183. [BibTeX]
- Behnisch, P. , Besselink, H. , Suzuki, G. , Buchinger, S. , Reifferscheid, G. , Lukas, M. , Wollenweber, M. , Wollenweber, S. & et al. (2024). Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay. Science of the Total Environment, 920. [BibTeX]
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2). [BibTeX]
- Sjöström, Y. , Hagström, K. , Lindh, C. , Bryngelsson, I. , Larsson, M. & Hagberg, J. (2023). Exposure to phthalates and DiNCH among preschool children in Sweden: Urinary metabolite concentrations and predictors of exposure. International journal of hygiene and environmental health, 250. [BibTeX]
- Eriksson, U. , Titaley, I. A. , Engwall, M. & Larsson, M. (2022). Examination of aryl hydrocarbon receptor (AhR), estrogenic and anti-androgenic activities, and levels of polyaromatic compounds (PACs) in tire granulates using in vitro bioassays and chemical analysis. Chemosphere, 298. [BibTeX]
- Titaley, I. A. , Delgado Trine, L. S. , Wang, T. , Duberg, D. , Davis, E. L. , Engwall, M. , Massey Simonich, S. L. & Larsson, M. (2022). Extensive chemical and bioassay analysis of polycyclic aromatic compounds in a creosote-contaminated superfund soil following steam enhanced extraction. Environmental Pollution, 312. [BibTeX]
- Nilén, G. , Obamwonyi, O. S. , Liem-Nguyen, V. , Engwall, M. , Larsson, M. & Keiter, S. (2022). Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio). Aquatic Toxicology, 248. [BibTeX]
- Titaley, I. , Lam, M. M. , Bülow, R. , Enell, A. , Wiberg, K. & Larsson, M. (2021). Characterization of polycyclic aromatic compounds in historically contaminated soil by targeted and non-targeted chemical analysis combined with in vitro bioassay. Environmental Pollution, 289. [BibTeX]
- Cormier, B. , Le Bihanic, F. , Cabar, M. , Crebassa, J. , Blanc, M. , Larsson, M. , Dubocq, F. , Yeung, L. W. Y. & et al. (2021). Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish. Journal of Hazardous Materials, 415. [BibTeX]
- Volchko, Y. , Berggren Kleja, D. , Back, P. , Tiberg, C. , Enell, A. , Larsson, M. , Jones, C. M. , Taylor, A. & et al. (2020). Assessing costs and benefits of improved soil quality management in remediation projects: A study of an urban site contaminated with PAH and metals. Science of the Total Environment, 707. [BibTeX]
- Titaley, I. A. , Eriksson, U. & Larsson, M. (2020). Rapid extraction method of polycyclic aromatic compounds in soil using basic silica selective pressurized liquid extraction. Journal of Chromatography A, 1618. [BibTeX]
- Titaley, I. , Massey Simonich, S. L. & Larsson, M. (2020). Recent Advances in the Study of the Remediation of Polycyclic Aromatic Compound (PAC)-Contaminated Soils: Transformation Products, Toxicity, and Bioavailability Analyses. Environmental Science and Technology Letters, 7 (12), 873-882. [BibTeX]
- Schönlau, C. , Larsson, M. , Lam, M. M. , Engwall, M. , Giesy, J. P. , Rochman, C. & Kärrman, A. (2019). Aryl hydrocarbon receptor-mediated potencies in field-deployed plastics vary by type of polymer. Environmental Science and Pollution Research, 26 (9), 9097-9088. [BibTeX]
- Meyer-Alert, H. , Larsson, M. , Hollert, H. & Keiter, S. (2019). Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio). Ecotoxicology and Environmental Safety, 183. [BibTeX]
- Schönlau, C. , Larsson, M. , Dubocq, F. , Rotander, A. , Van der Zande, R. , Engwall, M. & Kärrman, A. (2019). Effect-Directed Analysis of Ah Receptor-Mediated Potencies in Microplastics Deployed in a Remote Tropical Marine Environment. Frontiers in Environmental Science, 7. [BibTeX]
- Meyer-Alert, H. , Ladermann, K. , Larsson, M. , Schiwy, S. , Hollert, H. & Keiter, S. H. (2018). A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio). Aquatic Toxicology, 204, 117-129. [BibTeX]
- Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P. & Larsson, M. (2018). Methylated PACs Are More Potent than Their Parent Compounds: A Study on AhR-mediated Activity, Degradability and Mixture Interactions in the H4IIE-luc Assay. Environmental Toxicology and Chemistry, 37 (5), 1409-1419. [BibTeX]
- Lam, M. M. , Engwall, M. , Denison, M. S. & Larsson, M. (2018). Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. Environmental Toxicology and Chemistry, 37 (2), 385-397. [BibTeX]
- Larsson, M. , Lam, M. M. , van Hees, P. , Giesy, J. P. & Engwall, M. (2018). Occurrence and leachability of polycyclic aromatic compounds in contaminated soils: Chemical and bioanalytical characterization. Science of the Total Environment, 622-623, 1476-1484. [BibTeX]
- Hafner, C. , Gartiser, S. , Garcia-Kaeufer, M. , Schiwy, S. , Hercher, C. , Meyer, W. , Achten, C. , Larsson, M. & et al. (2015). Investigations on sediment toxicity of German rivers applying a standardized bioassay battery. Environmental Science and Pollution Research, 22 (21), 16358-16370. [BibTeX]
- Larsson, M. , Giesy, J. P. & Engwall, M. (2014). AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition. Environment International, 73, 94-103. [BibTeX]
- Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2014). An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 21 (9), 6243-6251. [BibTeX]
- Larsson, M. , Hagberg, J. , Giesy, J. P. & Engwall, M. (2014). Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 33 (4), 943-953. [BibTeX]
- Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B. & Engwall, M. (2013). Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils. Environmental Science and Pollution Research, 20 (12), 8511-8520. [BibTeX]
- Buitrago, B. H. , Munoz, P. F. , Ribe, V. , Larsson, M. , Engwall, M. , Wojciechowska, E. & Waara, S. (2013). Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays. Ecotoxicology and Environmental Safety, 97, 255-262. [BibTeX]
- Engwall, M. , Venizelos, N. , Westman, O. , Larsson, M. , Nordén, M. , Hollert, H. & Johansson, J. (2013). Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 20 (3), 1881-1888. [BibTeX]
- Larsson, M. , Orbe, D. & Engwall, M. (2012). Exposure time-dependent effects on the relative potencies and additivity of PAHs in the Ah receptor-based H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 31 (5), 1149-1157. [BibTeX]
Artiklar, forskningsöversikter
- Niarchos, G. , Alygizakis, N. , Carere, M. , Dulio, V. , Engwall, M. , Hyötyläinen, T. , Kallenborn, R. , Karakitsios, S. & et al. (2024). Pioneering an effect-based early warning system for hazardous chemicals in the environment. TrAC. Trends in analytical chemistry, 180. [BibTeX]
- Alijagic, A. , Hedbrant, A. , Persson, A. , Larsson, M. , Engwall, M. & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Frontiers in Immunology, 14. [BibTeX]
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in Toxicology, 4. [BibTeX]
- Lundstedt, S. , Bandowe, B. A. M. , Wilcke, W. , Boll, E. , Christensen, J. H. , Vila, J. , Grifoll, M. , Faure, P. & et al. (2014). First intercomparison study on the analysis of oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) and nitrogen heterocyclic polycyclic aromatic compounds (N-PACs) in contaminated soil. TrAC. Trends in analytical chemistry, 57, 83-92. [BibTeX]
Doktorsavhandlingar, sammanläggningar
- Larsson, M. (2013). Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists. (Doctoral dissertation). (Sammanläggning) Örebro: Örebro universitet. [BibTeX]
Konferensbidrag
- Alijagic, A. , Södergren Seilitz, F. , Bredberg, A. , Hakonen, A. , Larsson, M. , Sjöberg, V. , Kotlyar, O. , Persson, A. & et al. (2024). Comprehensive chemical and toxicological screening of e-waste plastic chemicals. I: Toxicology Letters. Konferensbidrag vid 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, Denmark, September 8-11, 2024. (ss. S66-S66). Elsevier. [BibTeX]
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. I: Toxicology Letters. Konferensbidrag vid XVIth International Congress of Toxicology (ICT 2022) - UNITING IN TOXICOLOGY, Maastricht, The Netherlands, September 18-21, 2022. (ss. S226-S227). Elsevier. [BibTeX]
- Larsson, M. , Orbe, D. & Engwall, M. (2012). Ah receptor activating capacity of polycyclic aromatic hydrocarbon derivatives. I: Toxicology Letters. Elsevier. [BibTeX]
- Westman, O. , Nordén, M. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2012). Reduced beta-oxidation in avian following exposure of polycyclic aromatic hydrocarbons. I: Toxicology Letters. Elsevier. [BibTeX]
Manuskript
- Sjöström, Y. , Holmes, B. , Ricklund, N. , Struwe, N. , Hagström, K. , Hagberg, J. & Larsson, M. Endocrine activities of dust in children's indoor environments : Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment. [BibTeX]
- Lam, M. M. , Engwall, M. , Denison, M. S. , Giesy, J. P. & Larsson, M. Polyoxymethylene (POM) is a suitable tool for effect-based hazard assessment of PAC-contaminated soil. [BibTeX]
- Schönlau, C. , Holmes, B. , Larsson, M. , Engwall, M. & Kärrman, A. Screening for bioactivities in three types of microplastics deployed in Swedish aquatic environments using a battery of reporter gene assays. [BibTeX]
- Rijk, I. , Ekblad, A. , Dahlin, A. S. , Enell, A. , Larsson, M. , Leroy, P. , Berggren Kleja, D. , Tiberg, C. & et al. The effects of biochar and peat amendment on the nitrogen cycle in a metal- and PAH-contaminated urban soil : results from a field trial. [BibTeX]
Rapporter
- Kärrman, A. , Bjurlid, F. , Hagberg, J. , Ricklund, N. , Larsson, M. , Stubleski, J. & Hollert, H. (2016). Study of environmental and human health impacts of firefighting agents: A technical report. Örebro, Sweden: Örebro University. [BibTeX]
- Engwall, M. & Larsson, M. (2009). Bioanalys av organiska föroreningars biotillgänglighet: tillämpning i sanerade massor. Stockholm: Naturvårdsverket (Rapport 5931). [BibTeX]