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Magnus Johansson

Befattning: Professor Organisation: Institutionen för medicinska vetenskaper

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Forskningsämne

Biomedicin

Om Magnus Johansson

Forskning

Magnus Johansson är molekylär virolog och hans forskning är inriktad på att förstå livscykeln för flavivirus, med ett speciellt fokus på Tick-borne encephalitis (TBE). Hans arbete omfattar ett brett spektrum av olika aspekter, inklusive förståelse av molekylära interaktioner mellan virus och värdcellens immunsvar, utveckling av infektiösa kloner och replicon för vaccinutveckling samt ökad förståelse för TBEs molekyär epidemiologi.

Kort karriärbeskrivning

Magnus Johansson disputerade 1998 vid Stockholms universitet, där hans forskning fokuserade på den genetiska och metabola regleringen av kvävemetabolism i bakterier. Hans specifika fokus var signalöverföring, uttryck och rening av proteiner och enzymatisk reglering via kovalent modifiering.

1999 gjorde ha en ”postdok” vid James Cook University i Queensland, Australien. Under sin tid vid James Cook University breddade han sin kompetens mot molekylär virologi genom att studera Dengue virus, ett myggburet flavivirus som orsakar svår blödarfeber i stora delar av världen. Hans forskning var inriktad på att förstå cellbiologiska roller för det virala RNA-beroende RNA-polymeraset, NS5.

Magnus Johansson började sin roll som självständig forskningsledare 2001, inledningsvis vid Stockholms universitet. 2002, tilldelades han en tjänst som forskarassistent av Vetenskapsrådet, för arbete att arbeta med biologisk mångfald hos TBE och andra flavivirus. Han flyttade senare sin forskargrupp till Södertörns högskola, där han utnämndes till Docent 2007. År 2008 slutförde han framgångsrikt MAL-programmet (Morgondagens Akademiska Ledarskap), ett ledarskapsutbildningsprogram inom SUUN-nätverket.

År 2012 flyttade han sin forskargrupp till Institutionen för medicinska vetenskaper vid Örebro universitet där han har varit proprefekt sedan 2015. År 2017 utnämndes han till professor i biomedicin med inriktning mot biokemi.

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter | Böcker | Konferensbidrag | Manuskript |

Artiklar i tidskrifter

Koskela, A. , Lindqvist, C. M. , Asghar, N. , Johansson, M. , Sundqvist, M. , Mölling, P. & Stenmark, B. (2023). Comparison of SARS-CoV-2 whole genome sequencing using tiled amplicon enrichment and bait hybridization. Scientific Reports, 13 (1). [BibTeX]
Omazic, A. , Wallenhammar, A. , Lahti, E. , Asghar, N. , Hanberger, A. , Hjertqvist, M. , Johansson, M. & Albihn, A. (2023). Dairy milk from cow and goat as a sentinel for tick-borne encephalitis virus surveillance. Comparative Immunology, Microbiology & Infectious Diseases, 95. [BibTeX]
Burm, R. , Maravelia, P. , Ahlen, G. , Ciesek, S. , Caro Perez, N. , Pasetto, A. , Urban, S. , Van Houtte, F. & et al. (2023). Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections.. Gut, 72 (6), 1186-1195. [BibTeX]
Kjær, L. J. , Johansson, M. , Lindgren, P. , Asghar, N. , Wilhelmsson, P. , Fredlund, H. , Christensson, M. , Wallenhammar, A. & et al. (2023). Potential drivers of human tick-borne encephalitis in the Örebro region of Sweden, 2010-2021. Scientific Reports, 13 (1). [BibTeX]
Tran, P. T. H. , Höglund, U. , Larsson, O. , Appelberg, S. , Mirazimi, A. , Johansson, M. & Melik, W. (2022). Enhanced Seroconversion to West Nile Virus Proteins in Mice by West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean-Congo Hemorrhagic Fever Virus. Pathogens, 11 (2). [BibTeX]
Tran, P. T. H. , Chiramel, A. I. , Johansson, M. & Melik, W. (2022). Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection. Journal of Virology, 96 (3). [BibTeX]
Asghar, N. , Melik, W. , Paulsen, K. M. , Pedersen, B. N. , Bø-Granquist, E. G. , Vikse, R. , Stuen, S. , Andersson, S. & et al. (2022). Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana . Vaccines, 10 (10). [BibTeX]
Maravelia, P. , Frelin, L. , Ni, Y. , Pérez, N. C. , Ahlén, G. , Jagya, N. , Verch, G. , Verhoye, L. & et al. (2021). Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections. Journal of Infectious Diseases, 223 (1), 128-138. [BibTeX]
Tran, P. , Asghar, N. , Johansson, M. & Melik, W. (2021). Roles of the Endogenous Lunapark Protein during Flavivirus Replication. Viruses, 13 (7). [BibTeX]
Tran, P. T. H. , Asghar, N. , Höglund, U. , Larsson, O. , Haag, L. , Mirazimi, A. , Johansson, M. & Melik, W. (2020). Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice. Microorganisms, 8 (12). [BibTeX]
Wallenhammar, A. , Lindqvist, R. , Asghar, N. , Gunaltay, S. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby, A. K. & et al. (2020). Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk. Parasites & Vectors, 13 (1). [BibTeX]
Lindqvist, R. , Rosendal, E. , Weber, E. , Asghar, N. , Schreier, S. , Lenman, A. , Johansson, M. , Dobler, G. & et al. (2020). The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection. Journal of Neuroinflammation, 17 (1). [BibTeX]
Asghar, N. , Pettersson, J. H. , Dinnetz, P. , Andreassen, Å. & Johansson, M. (2017). Deep sequencing analysis of tick-borne encephalitis virus from questing ticks at natural foci reveals similarities between quasispecies pools of the virus. Journal of General Virology, 98 (3), 413-421. [BibTeX]
Asghar, N. , Petersson, M. , Johansson, M. & Dinnetz, P. (2016). Local landscape effects on population dynamics of Ixodes ricinus. Geospatial health, 11 (3), 283-289. [BibTeX]
Bertrand, Y. J. K. , Johansson, M. & Norberg, P. (2016). Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach. PLOS ONE, 11 (10). [BibTeX]
Asghar, N. , Lee, Y. , Nilsson, E. , Lindqvist, R. , Melik, W. , Kröger, A. , Överby, A. K. & Johansson, M. (2016). The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus. Scientific Reports, 6. [BibTeX]
Asghar, N. , Lindblom, P. , Melik, W. , Lindqvist, R. , Haglund, M. , Forsberg, P. , Överby, A. K. , Andreassen, Å. & et al. (2014). Tick-Borne Encephalitis Virus Sequenced Directly from Questing and Blood-Feeding Ticks Reveals Quasispecies Variance. PLOS ONE, 9 (7). [BibTeX]
Rytkonen, P. , Bonow, M. , Johansson, M. & Persson, Y. (2013). Goat cheese production in Sweden: a pioneering experience in the re-emergence of local food. Acta Agriculturae Scandinavica - Section B, 63 (Suppl. 1), 38-46. [BibTeX]
Hamsten, C. , Starkhammar, M. , Tran, T. A. , Johansson, M. , Bengtsson, U. , Ahlén, G. , Sällberg, M. , Grönlund, H. & et al. (2013). Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. Allergy. European Journal of Allergy and Clinical Immunology, 68 (4), 549-552. [BibTeX]
Wigerius, M. , Asghar, N. , Melik, W. & Johansson, M. (2013). Scribble controls NGF-mediated neurite outgrowth in PC12 cells. European Journal of Cell Biology, 92 (6-7), 213-221. [BibTeX]
Bertrand, Y. , Töpel, M. , Elväng, A. , Melik, W. & Johansson, M. (2012). First dating of a recombination event in mammalian tick-borne flaviviruses. PLOS ONE, 7 (2). [BibTeX]
Melik, W. , Ellencrona, K. , Wigerius, M. , Hedström, C. , Elväng, A. & Johansson, M. (2012). Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication. Virus Research, 169 (1), 54-62. [BibTeX]
Elväng, A. , Melik, W. , Bertrand, Y. , Lönn, M. & Johansson, M. (2011). Sequencing of a tick-borne encephalitis virus from Ixodes ricinus reveals a thermosensitive RNA switch significant for virus propagation in ectothermic arthropods. Vector Borne and Zoonotic Diseases, 11 (6), 649-658. [BibTeX]
Wigerius, M. , Melik, W. , Elväng, A. & Johansson, M. (2010). Rac1 and Scribble are targets for the arrest of neurite outgrowth by TBE virus NS5. Molecular and Cellular Neuroscience, 44 (3), 260-271. [BibTeX]
Ellencrona, K. , Syed, A. & Johansson, M. (2009). Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism. Biological chemistry (Print), 390 (4), 319-323. [BibTeX]
Werme, K. , Wigerius, M. & Johansson, M. (2008). Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.. Cellular Microbiology, 10 (3), 696-712. [BibTeX]
Melik, W. , Nilsson, A. S. & Johansson, M. (2007). Detection strategies of tick-borne encephalitis virus in Swedish Ixodes ricinus reveal evolutionary characteristics of emerging tick-borne flaviviruses. Archives of Virology, 152 (5), 1027-1034. [BibTeX]
Brooks, A. J. , Johansson, M. , John, A. V. , Xu, Y. , Jans, D. A. & Vasudevan, S. G. (2002). The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. Journal of Biological Chemistry, 277 (39), 36399-36407. [BibTeX]
Johansson, M. , Brooks, A. J. , Jans, D. A. & Vasudevan, S. G. (2001). A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3. Journal of General Virology, 82 (Pt 4), 735-745. [BibTeX]
Vasudevan, S. G. , Johansson, M. , Brooks, A. J. , Llewellyn, L. E. & Jans, D. A. (2001). Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets. Il Farmaco, 56 (1-2), 33-36. [BibTeX]
Cheng, J. , Johansson, M. & Nordlund, S. (1999). Expression of P(II) and glutamine synthetase is regulated by P(II), the ntrBC products, and processing of the glnBA mRNA in Rhodospirillum rubrum. Journal of Bacteriology, 181 (20), 6530-6534. [BibTeX]
Johansson, M. & Nordlund, S. (1999). Purification of P(II) and P(II)-UMP and in vitro studies of regulation of glutamine synthetase in Rhodospirillum rubrum. Journal of Bacteriology, 181 (20), 6524-6529. [BibTeX]
Johansson, M. & Nordlund, S. (1997). Uridylylation of the P(II) protein in the photosynthetic bacterium Rhodospirillum rubrum. Journal of Bacteriology, 179 (13), 4190-4194. [BibTeX]
Lindblad, A. , Jansson, J. , Brostedt, E. , Johansson, M. , Hellman, U. & Nordlund, S. (1996). Identification and sequence of a nifJ-like gene in Rhodospirillum rubrum: partial characterization of a mutant unaffected in nitrogen fixation. Molecular Microbiology, 20 (3), 559-568. [BibTeX]
Johansson, M. & Nordlund, S. (1996). Transcription of the glnB and glnA genes in the photosynthetic bacterium Rhodospirillum rubrum. Microbiology, 142 ( Pt 5), 1265-1272. [BibTeX]

Böcker

Venizelos, N. , Sirsjö, A. , Ericsson, E. , Johansson, M. , Hjelmqvist, H. , Jendle, J. , Eriksson, M. , Karlsson, M. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ericsson, E. (ed.) , Johansson, M. (ed.) , Hjelmqvist, H. (ed.) , Jendle, J. (ed.) , Eriksson, M. (ed.) , Karlsson, M. (ed.) & Möller, M. (ed.) (2018). Örebro University’s Nobel Day Festivities: Book of abstracts, 2018. Örebro: Örebro universitet. [BibTeX]

Konferensbidrag

Asghar, N. , Maravelia, P. , Ahlen, G. , Jaafar, R. , Frelin, L. , Larsson, O. , Johansson, C. , Sällberg, M. & et al. (2024). Flavivirus replicon-based novel vaccine candidates against Hepatitis viruses. Konferensbidrag vid 21st Smögen Summer Symposium on Virology, Smögen, August 22-24, 2024. [BibTeX]
Jaafar, R. , Asghar, N. , Ljungberg, K. , Melik, W. & Johansson, M. (2024). Pre-Clinical Development of a Novel Tick-Borne Encephalitis Vaccine for Mucosal Immunization. Konferensbidrag vid 21st Smögen Summer Symposium on Virology, Smögen, August 22-24, 2024. [BibTeX]
Koskela, A. , Lindqvist, C. M. , Asghar, N. , Johansson, M. , Sundqvist, M. , Mölling, P. & Stenmark, B. (2023). Comparison of SARS-CoV-2 whole genome sequencing using tiled amplicon enrichment and bait hybridization. Konferensbidrag vid Smögen Virology Symposium 2023, Smögen, Sweden, August 24-26, 2023. [BibTeX]
Asghar, N. , Jaafar, R. , Lindqvist, C. M. , Ljunberg, K. & Johansson, M. (2023). Design, rescue, and characterization of Langat virus infectious clone by next generation sequencing. Konferensbidrag vid 20th Smögen Summer Symposium on Virology, Smögen, August 24-26, 2023. (ss. 51-51). [BibTeX]
Jaafar, R. , Asghar, N. , Ljungberg, K. , Melik, W. & Johansson, M. (2023). Development of a potential live-attenuated Langat virus as candidate for novel tick-borne encephalitis vaccine. Konferensbidrag vid 39th annual meeting of NSCMID, Örebro, 21-24 September, 2023. [BibTeX]
Jaafar, R. , Asghar, N. , Ljungberg, K. , Melik, W. & Johansson, M. (2023). Development of Live attenuated Langat virus infectious clone as potential new TBEV vaccine candidate: Study of cellular and humoral immune response in mice. Konferensbidrag vid 20th Smögen Summer Symposim on Virology, Smögen, August 24-26, 2023. [BibTeX]
Alim, A. , Pelli, F. , Asghar, N. , Melik, W. & Johansson, M. (2023). Tick-borne encephalitis virus protein expression to develop novel subunit vaccines and diagnostic tools. Konferensbidrag vid 20th Smögen Summer Symposium on Virology, Smögen, Sweden, August 24-26, 2023. [BibTeX]
Wallenhammar, A. , Koskela, A. , Asghar, N. & Johansson, M. (2020). Developing a quantitative technique for detection of low levels ofTBE virus in ticks and milk. I: ÖREBRO UNIVERSITY’S NOBEL DAY FESTIVITIES BOOK OF ABSTRACTS. Konferensbidrag vid ÖREBRO UNIVERSITY’S NOBEL DAY FESTIVITIES, Örebro, 9 December, 2020. (ss. 19-19). Örebro University. [BibTeX]
Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Identification and characterization of host proteins inducing the endoplasmic reticulum invagination during Flavivirus infection. I: Positive-Strand RNA Viuses. Konferensbidrag vid Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019. (ss. 280-280). [BibTeX]
Johansson, M. , Frelin, L. , Maravelia, P. , Asghar, N. , Melik, W. , Caro-Perez, N. , Pasetto, A. , Ahlen, G. & et al. (2019). Immunogenicity of a New Flaviviral-Based DNA Launched Suicidal Replicon for Protective Vaccination Against Hepatitis C. I: Molecular Therapy. Konferensbidrag vid 22nd Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, USA, April 29 - May 2, 2019,. (ss. 139-139). Cell Press. [BibTeX]
Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Konferensbidrag vid Positive-Strand RNA Viruses (E2), Killarney, Co. Kerry Ireland, June 9-13, 2019. [BibTeX]
Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, P. T. H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Konferensbidrag vid 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019. [BibTeX]
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Lindqvist, R. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby Wernstedt, A. & et al. (2019). Revealing new tick-borne encephalitis foci by screening antibodies in sheep milk. I: 16th Smögen Symposium on Virology, August 22-24, 2019. Konferensbidrag vid 16th Smögen Symposium on Virology, Smögen, Sweden, August 22-24, 2019. [BibTeX]
Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zika replication complex. I: Positive-Strand Rna Viuses. Konferensbidrag vid Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019. [BibTeX]
Tran, P. T. H. , Asghar, N. , Karlsson, A. , Karlsson, R. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zikareplication complex. I: 16th Smögen Summer Symposium on Virology. Konferensbidrag vid 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019. [BibTeX]
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Andersson, S. , Davidsson, Å. , Överby Wernstedt, A. & Johansson, M. (2018). Developing a novel strategy to determine new Tick-borne encephalitis foci. I: 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018.. Konferensbidrag vid 15th Smögen Summer Symposium on Virology, August 23-25, 2018. [BibTeX]
Asghar, N. , Gunaltay, S. , Tran, P. T. H. , Melik, W. , Höglund, U. , Johansson, C. , Frelin, L. , Sällberg, M. & et al. (2018). DNA launched suicidal flaviviruses as therapeutic vaccine candidates. Konferensbidrag vid 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018. [BibTeX]
Johansson, M. (2017). Development of an edible Tick-borne encephalitis vaccine. Konferensbidrag vid SNÄFF (Svenska nätverket för fästing forskare) 2017, Varberg, Sweden, 3-5 maj 2017. [BibTeX]
Asghar, N. , Wessam, M. , Lindblom, P. , Lindgren, P. , Andreassen, Å. & Johansson, M. (2013). Genomic Sequencing of Tick-borne Encephalitis Virus frin Questing and Blood-Feeding Ixodes ricinus. Konferensbidrag vid Positive strand RNA viruses, Boston, Massachusetts, USA, April 28 - May 3 2013. [BibTeX]

Manuskript

Tran, P. , Karlsson, R. , Karlsson, A. , Asghar, N. , Melik, W. & Johansson, M. Proteomic screening identifies TRIM21 and TRIM14 as antiviral proteins against Langat virus and Zika virus. [BibTeX]