Regulation and early signs of immunosuppression in sepsis

Immunosuppression has been shown to contribute to increased morbidity and mortality in sepsis, and is regarded as a contributor to the failure of trials of immunsuppressive agents. However, the mechanisms behind immunosuppression and tools for identifying immunosuppressed patients in sepsis is largely lacking. This project aim at understanding these early mechanisms responsible for inducing immunosuppression by studing both novel and previous markers associated with immunosuppression in a cohort of ambulance patients with suspected infection (the so called PREDICT-study)