Project bank NGBI
Student projects are presented here. In the project bank, you can either search by subject areas or by entering keywords in the search box. You can also choose a letter, and you will see the projects that start with that letter in the title.
Project within Parkinson's disease
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The role of intestinal barrier function in patients with Parkinson's disease
Parkinson's disease (PD) is currently the second most prevalent neurodegenerative disease in the world, primarily affecting older individuals with degeneration of the motor-controlling nerve components in the brain. Most patients with PD also suffer from gastrointestinal issues such as constipation and inadequate bowel movements, sometimes for years before PD is diagnosed.
There are few studies on PD regarding potential disruptions in the communication between the gut and brain (the gut-brain axis), but it appears that both the immune cells and nerve cells in the gut may play an important role in the disease's development.
We aim to study whether increased intestinal permeability (reduced barrier function), sometimes referred to as leaky gut, could play an important role for the heightened immune activation and the characteristic gastrointestinal symptoms seen in PD patients.
Read more about The role of intestinal barrier function in patients with Parkinson's disease