Inflammatory Response and Infection Susceptibility Centre (iRiSC)
The iRiSC - Inflammatory Response and Infection Susceptibility Center includes researchers from Örebro University and Örebro University Hospital (USÖ), and collaborate with a number of national and international research groups.
News & Media
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We are excited to be involved in this project
SEK 13.2 Million Awarded for Research on the Heart's Susceptibility to Viruses and Environmental Toxins.
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Congratulations to our new Docent, Alexander Hedbrant
Congratulations to our new Docent, Alexander Hedbrant. We would like to congratulate one of our researchers, Alexander Hedbrant, whom was newly appointed Docent in Medical Science with a specialization in Biomedicine at Örebro University, Sweden.
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Awarded Prize for Promising Research
We are honored to have Dr. Alijagic as part of out research center! Andi Alijagic researches how microplastics, airborne particles, and chemicals affect human health. He has now been awarded the Eric K. Fernström Prize 2026 for young, particularly...
About this group
Group information
Contact
Research subject
Areas of research
- Biochemistry
- Biomedicine
- Immunology
- Infection
- Inflammation
- Medicine
- Microbiology
- Environment and Health
The Research platform iRiSC - Inflammatory Response and Infection Susceptibility Centre is a collaborative network of researchers at Örebro University and Örebro University Hospital (USÖ), together with a number of national and international research groups. The research at iRiSC is focused on understanding response to stimuli and stressors i.e. microbes and their pathogen-associated molecular patterns (PAMPs) as well as danger-associated molecular patterns (DAMPs), e.g. nano particles. By connecting different disciplines and research fields, iRiSC is a translational platform; bringing together knowledge and experience on particle-induced diseases, specific bacteria and their disease course, host response mechanisms and the role of genetics.
Researchers
- Andi Alijagic
- Sören Andersson
- Berhane Asfaw
- Naveed Asghar
- Simon Athlin
- Susanne Bejerot
- Daniel Eklund
- Alexander Hedbrant
- Hans Hjelmqvist
- Ulrika Hylén
- Mikael Ivarsson
- Johan Jendle
- Magnus Johansson
- Hazem Khalaf
- Robert Kruse
- Lisa Kurland
- Magnus Lindberg
- Olle Ljungqvist
- Wessam Melik
- Eewa Nånberg
- Alexander Persson
- Katarina Persson
- Amanj Saber
- Samira Salihovic
- Åke Strid
- Eva Särndahl
- Bo Söderquist
- Elisabet Welin
- Maria Åström
- Annika Granath, PhD student
- Sofia Sigra Stein, PhD student
- Kedeye Tuerxun, PhD student
Research projects
Active projects
- Cobalt in the hard metal industry - lung and skin exposure and the implications for keratinocytes with regards to inflammasome activity
- Exposure to particles and biomarkers of inflammatory responses in workers in pulp and paper industry
- Functional Studies of Flavivirus-Host Cell Interactions
- Gene variants of the NLRP3 inflammasome in Neisseria meningitidis-induced severe infection
- Gene variants of the NLRP3 inflammasome in Staphylococcus aureus-induced severe infection
- Identification of viral RNA sequence determinants and viral/cellular proteins involved in regulation of flavivirus replication: implications for vaccine design
- Intracellular bacterial communities (IBC) and recurrent urinary tract infections
- Long term effect on immune response after pneumococcal vaccination in patients with chronic lymphocytic leukemia and evaluation of the effect of revaccination (KLLVAC-2018)
- MCbär-Swedens first study regarding meningococcal carriage
- Molecular epidemiology of the Tick borne encephalitis virus
- NanoSafety2
- Neisseria meningitidis-induced sepsis
- PolluSense - Developing novel target and non-target biosensors to assess pollutant impacts on innate immunity
- Regulation and early signs of immunosuppression in sepsis
- Regulation of Inflammasomes
- Reprogrammed monocytes during infections and sepsis
- S. aureus-induced sepsis
- The detrimental effect of bacterial infections in the cf lung
Completed projects
- Inflammasome activity and regulation in neutrophils
- Inflammation and fibrosis- what are the mechanisms ?
- MILAS
- Multiresistant ESBL-producing uropathogens - studies of antibacterial strategies and pathogenesis mechanisms
- NANOSIGN
- Occupational particle exposure: Different environments, but the same risks?
- Prevalence and prognostic implications of cardiac injury in patients with influenza-like illness
- Quartz- and particle exposure in iron foundries- mechanisms and impact on inflammation and coagulation markers for respiratory effects and cardiovascular disease
- Rituximab - Immunotherapy for Obsessive-Compulsive Disorder. A pilot study.
- Rituximab for schizophrenia spectrum disorder. A pilot study.
- SP110 as a novel regulator of innate immune inflammasomes
