Yvonne Freund Levi
Befattning: Universitetslektor Organisation: Institutionen för medicinska vetenskaperE-post: eXZvbm5lLmZyZXVuZDtvcnUuc2U=
Telefon: 019 302414, 0736 841130
Rum: X1107
Om Yvonne Freund Levi
Yvonne Freund är lektor klinisk neurovetenskap, överläkare i geriatrik, psykiatriker och legitimerad KBT-terapeut steg 2. Hon är också mindfulnessinstruktör. Hon disputerade 2008 med en avhandling om behandling med omega-3 vid Alzheimers sjukdom och blev docent i klinisk neurovetenskap vid Karolinska Institutet 2015.
Forskning
Yvonne Freund forskar om psykiatri för äldre och neuropsykiatriska symptom vid demens (BPSD). Forskningen om äldre med demens innefattar hur förändringar i livsstil, nutrition och läkemedel på verkar sjukdomen.
Hon studerar hur biomarkörer i ryggmärgsvätska kan förutspå Alzheimers sjukdom långt före det att sjukdomen bryter ut. En viss typ av biomarkörer finns hos människor med depression och sömnsvårigheter, symptom som också kan kopplas till tidiga stadier av Alzheimers sjukdom. Målet för forskningen är att kunna sätta in behandling så tidigt som möjligt eftersom neuropsykiatriska sjukdomar kan få allvarliga konsekvenser och ökat lidande för Alzheimer-patienter och anhöriga.
En annan studie visar att personer med Alzheimers sjukdom som åt tillskott med omega-3-fettsyror förbättrade sina resultat på minnestester. Resultaten pekar på att och omega-3-rik mat som fet fisk, kan vara ett sätt att mildra Alzheimer i ett tidigt skede.
I ett projekt undersöker hon behovet av rehabilitering hos dem som drabbats av covid-19, genom att kartlägga biomarkörer för infektionen med målet att utveckla individuell behandling för fysiska, psykiska och kognitiva funktioner som påverkats av sjukdomen.
I ett annat projekt utvärderar Yvonne Freund en ny typ av inkontinenshjälpmedel som provas på kvinnor på särskilda boende, för att se hur livskvaliteten påverkas och om det går att förebygga urinvägsinfektioner.
I en tidigare studie visar Yvonne Freund att träning är lika effektivt som läkemedel vid lindrig eller måttlig depression, och är dessutom bra för den psykiska hälsan i stort. Resultatet visar att fysisk aktivitet minskar risken för ångest, stress och utbrändhet. Dessutom ökar träningen självkänslan och förbättrar sömnen.
Hon har också forskat om hur mindfulness kan användas för behandling av stress och depression.
Hon leder forskargruppen Kognitiv medicin och biomarkörer vid ORU och är huvudhandledare för tre doktorander: Zbigniew Dzialanski, Qiwei Zhai, Anders Funqvist.
Undervisning
Yvonne Freund ansvarar för en del av utbildningen i psykiatri på Läkarprogrammet, under hela studietiden. Hon undervisar i psykiatri, stress, kognitiva sjukdomar, kognitiv psykoterapi och psykodynamisk terapi, i psykiatri för äldre och inom geriatrisk vård och demenssjukdomar. Hon undervisar också om hur läkemedel påverkar det centrala nervsystemet, mindfulness och i kognitiv medicin.
Hon leder också den grupp av lärare på Läkarprogrammet vid Örebro universitet som ansvarar för att ta hand om den psykiska hälsan hos läkarstudenterna, som bland annat står bakom särskilda insatser för att motverka stress.
Samarbeten och uppdrag
- Ledamot av Expertrådet Geriatrik Region Stockholm.
- Ledamot i “Nutrition for Aging Populations vid The New York Academy of Science”.
- Ledamot för “Kloka lista” vid Region Stockholm utvärdera behandling av läkemedel hos äldre.
- Regelbundet anlitad som föreläsare av Alzheimer Sverige och Demensförbundet.
- Forskningssamarbeten med Enzymotec Company, Tel Aviv University och Institutionen för neurobiologi, vårdvetenskap och samhälle (NVS) vid Karolinska Institutet.
- Hon utför också digitala kognitiva utredningar på uppdrag av Geras solution.
- Medlem i det vetenskapliga rådet för ”World congress for controversies in neurology” mars 2022.
Forskargrupper
Publikationer
Artiklar i tidskrifter
- Smith, R. G. , Pishva, E. , Kouhsar, M. , Imm, J. , Dobricic, V. , Johannsen, P. , Wittig, M. , Franke, A. & et al. (2024). Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 20 (10), 6722-6739. [BibTeX]
- Koetsier, J. , Freund-Levi, Y. , Pishva, E. & Alzheimer's Disease Neuroimaging Initiative, -. (2024). Blood-based multivariate methylation risk score for cognitive impairment and dementia. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 20 (10), 6682-6692. [BibTeX]
- Delvenne, A. , Gobom, J. , Schindler, S. E. , Kate, M. T. , Reus, L. M. , Dobricic, V. , Tijms, B. M. , Benzinger, T. L. S. & et al. (2024). CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 20 (9), 6205-6220. [BibTeX]
- Mattsson, P. , Cselényi, Z. , Forsberg Morén, A. , Freund-Levi, Y. , Wahlund, L. , Halldin, C. & Farde, L. (2024). High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer's Disease Using [11C]AZD2184. Journal of Alzheimer's Disease, 98 (4), 1391-1401. [BibTeX]
- Delvenne, A. , Vandendriessche, C. , Gobom, J. , Burgelman, M. , Dujardin, P. , De Nolf, C. , Tijms, B. M. , Teunissen, C. E. & et al. (2024). Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies. Fluids and Barriers of the CNS, 21 (1). [BibTeX]
- Delvenne, A. , Gobom, J. , Tijms, B. , Bos, I. , Reus, L. M. , Dobricic, V. , Kate, M. T. , Verhey, F. & et al. (2023). Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 19 (3), 807-820. [BibTeX]
- Funkquist, A. , Wandt, B. , Blennow, K. , Zetterberg, H. , Svensson, J. , Bjellerup, P. , Freund-Levi, Y. & Sjöberg, S. (2023). Higher CSF/serum free-T4 ratio is associated with improvement of quality of life during treatment with L-thyroxine. Journal of neuroendocrinology, 35. [BibTeX]
- Bloniecki, V. , Ulfvarson, J. , Javanshiri, K. , Hagman, G. , Freund-Levi, Y. & Nordström, A. (2023). The Geras Solutions Cognitive Test for Assessing Cognitive Impairment: Normative Data from a Population-Based Cohort. The Journal of Prevention of Alzheimer's Disease, 2 (10), 207-211. [BibTeX]
- Küçükali, F. , Neumann, A. , Van Dongen, J. , De Pooter, T. , Joris, G. , De Rijk, P. , Ohlei, O. , Dobricic, V. & et al. (2023). Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 19 (6), 2317-2331. [BibTeX]
- Visser, P. J. , Reus, L. M. , Gobom, J. , Jansen, I. , Dicks, E. , van der Lee, S. J. , Tsolaki, M. , Verhey, F. R. J. & et al. (2022). Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular Neurodegeneration, 17 (1). [BibTeX]
- Wesenhagen, K. E. J. , Gobom, J. , Bos, I. , Vos, S. J. B. , Martinez-Lage, P. , Popp, J. , Tsolaki, M. , Vandenberghe, R. & et al. (2022). Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition. Alzheimer's & dementia (Amsterdam, Netherlands), 14 (1). [BibTeX]
- Holmgren, S. , Andersson, T. , Berglund, A. , Aarsland, D. , Cummings, J. & Freund-Levi, Y. (2022). Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography. The Journal of Neuropsychiatry and Clinical Neurosciences, 34 (3), 214-223. [BibTeX]
- Jansen, W. J. , Janssen, O. , Tijms, B. M. , Vos, S. J. B. , Ossenkoppele, R. , Visser, P. J. & Freund-Levi, Y. (2022). Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurology, 79 (3), 228-243. [BibTeX]
- Neumann, A. , Küçükali, F. , Bos, I. , Vos, S. J. B. , Engelborghs, S. , De Pooter, T. , Joris, G. , De Rijk, P. & et al. (2022). Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation. Molecular Psychiatry, 27 (4), 1990-1999. [BibTeX]
- Ghafouri, B. , Ernberg, M. , Andréll, P. , Bäckryd, E. , Fisher, M. R. , Freund-Levi, Y. , Grelz, H. , Gräbel, O. & et al. (2022). Swedish Chronic Pain Biobank: protocol for a multicentre registry and biomarker project. BMJ Open, 12 (11). [BibTeX]
- Janssen, O. , Freund-Levi, Y. & Visser, P. J. (2021). Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 18 (10), 1832-1845. [BibTeX]
- Tijms, B. M. , Gobom, J. , Teunissen, C. , Dobricic, V. , Tsolaki, M. , Verhey, F. , Popp, J. , Martinez-Lage, P. & et al. (2021). CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes, 9 (3). [BibTeX]
- Tofiq, a. , Zetterberg, H. , Blennow, K. , Basun, H. , Cederholm, T. , Eriksdotter, M. , Faxén-Irving, G. , Hjorth, E. & et al. (2021). Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study. Journal of Alzheimer's Disease, 83 (3), 1291-1301. [BibTeX]
- Shi, L. , Freund-Levi, Y. & Nevado-Holgado, A. J. (2021). Replication study of plasma proteins relating to Alzheimer's pathology. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 17 (9), 1452-1464. [BibTeX]
- Xu, J. , Green, R. , Kim, M. , Lord, J. , Ebshiana, A. , Westwood, S. , Baird, A. L. , Nevado-Holgado, A. J. & et al. (2021). Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort. Biomedicines, 9 (11). [BibTeX]
- Bloniecki, V. , Zetterberg, H. , Aarsland, D. , Vannini, P. , Kvartsberg, H. , Winblad, B. , Blennow, K. & Freund-Levi, y. (2020). Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?. Alzheimer's Research & Therapy, 12 (1). [BibTeX]
- Shi, L. , Freund-Levi, Y. & Lovestone, S. (2020). Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease, 77 (3), 1353-1368. [BibTeX]
- Westwood, S. , Baird, A. L. , Anand, S. N. , Nevado-Holgado, A. J. , Kormilitzin, A. , Shi, L. , Hye, A. , Ashton, N. J. & et al. (2020). Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. Journal of Alzheimer's Disease, 74 (1), 213-225. [BibTeX]
- Stamate, D. , Kim, M. , Proitsi, P. , Weestwood, S. , Baird, A. , Nevado-Holgado, A. , Hye, A. , Bos, I. & et al. (2019). A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 5 (C), 933-938. [BibTeX]
- van Maurik, I. S. , Vos, S. J. , Bos, I. , Bouwman, F. H. , Teunissen, C. E. , Scheltens, P. , Barkhof, F. , Frolich, L. & et al. (2019). Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study. Lancet Neurology, 18 (11), 1034-1044. [BibTeX]
- Bos, I. , Vos, S. , Verhey, F. , Scheltens, P. , Teunissen, C. , Engelborghs, S. , Sleegers, K. , Frisoni, G. & et al. (2019). Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 15 (5), 644-654. [BibTeX]
- Shi, L. , Freund-Levi, Y. & Nevado-Holgado, A. J. (2019). Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 15 (11), 1478-1488. [BibTeX]
- Vermunt, L. , Sikkes, S. A. M. , van den Hout, A. , Handels, R. , Bos, I. , van der Flier, W. M. , Kern, S. , Ousset, P. & et al. (2019). Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 15 (7), 888-898. [BibTeX]
- Jernerén, F. , Cederholm, T. , Refsum, H. , Smith, A. D. , Turner, C. , Palmblad, J. , Eriksdotter, M. , Hjorth, E. & et al. (2019). Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study. Journal of Alzheimer's Disease, 69 (1), 189-197. [BibTeX]
- Lleó, A. , Alcolea, D. , Martínez-Lage, P. , Scheltens, P. , Parnetti, L. , Poirier, J. , Simonsen, A. H. , Verbeek, M. M. & et al. (2019). Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 15 (6), 742-753. [BibTeX]
- Kim, M. , Snowden, S. , Suvitaival, T. , Ali, A. , Merkler, D. J. , Ahmad, T. , Westwood, S. , Baird, A. & et al. (2019). Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 15 (6), 817-827. [BibTeX]
- Bos, I. , Vos, S. J. B. , Jansen, W. J. , Vandenberghe, R. , Gabel, S. , Estanga, A. , Ecay-Torres, M. , Tomassen, J. & et al. (2018). Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data.. Frontiers in Aging Neuroscience, 10. [BibTeX]
- Jansen, W. J. , Visser, P. J. , Amyloid Biomarker Study Group, . & Freund-Levi, Y. (2018). Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA psychiatry, 75 (1), 84-95. [BibTeX]
- Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages. Alzheimer's Research & Therapy, 10 (56). [BibTeX]
- Faxen-Irving, G. , Falahati, F. , Basun, H. , Eriksdotter, M. , Vedin, I. , Wahlund, L. , Schultzberg, M. , Hjorth, E. & et al. (2018). Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?. Journal of Alzheimer's Disease, 61 (2), 515-519. [BibTeX]
- Mattsson, N. , Freund-Levi, Y. & Ossenkoppele, R. (2018). Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 14 (7), 913-924. [BibTeX]
- Reijs, B. L. R. , Vos, S. J. B. , Soininen, H. , Lötjonen, J. , Koikkalainen, J. , Pikkarainen, M. , Hall, A. , Vanninen, R. & et al. (2017). Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease, 60 (4), 1387-1395. [BibTeX]
- Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9 (1). [BibTeX]
- Karimi, M. , Vedin, I. , Freund-Levi, Y. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Wahlund, L. , Schultzberg, M. & et al. (2017). DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 106 (4), 1157-1165. [BibTeX]
- Bloniecki, V. , Aarsland, D. , Blennow, K. , Cummings, J. , Falahati, F. , Winblad, B. & Freund-Levi, Y. (2017). Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid. Journal of Alzheimer's Disease, 57 (2), 387-393. [BibTeX]
- van Waalwijk van Doorn, L. J. C. , Freund-Levi, Y. & Verbeek, M. M. (2017). Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes. Journal of Alzheimer's Disease, 56 (2), 543-555. [BibTeX]
- Handels, R. L. H. , Vos, S. J. B. , Kramberger, M. G. , Jelic, V. , Blennow, K. , van Buchem, M. , van der Flier, W. , Freund-Levi, Y. & et al. (2017). Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. Alzheimer's & Dementia: Journal of the Alzheimer's Association, 13 (8), 903-912. [BibTeX]
- Bos, I. , Vos, S. J. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40. [BibTeX]
- Wang, X. , Hjorth, E. , Vedin, I. , Eriksdotter, M. , Freund-Levi, Y. , Wahlund, L. , Cederholm, T. , Palmblad, J. & et al. (2015). Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study. Journal of Lipid Research, 56 (3), 674-681. [BibTeX]
- Eriksdotter, M. , Vedin, I. , Falahati, F. , Freund-Levi, Y. , Hjorth, E. , Faxen-Irving, G. , Wahlund, L. , Schultzberg, M. & et al. (2015). Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. Journal of Alzheimer's Disease, 48 (3), 805-812. [BibTeX]
- Hall, A. , Mattila, J. , Koikkalainen, J. , Lötjonen, J. , Wolz, R. , Scheltens, P. , Frisoni, G. , Tsolaki, M. & et al. (2015). Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index. Current Alzheimer Research, 12 (1), 69-79. [BibTeX]
- Vos, S. J. B. , Verhey, F. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2015). Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain, 138 (5), 1327-1338. [BibTeX]
- Jansen, W. J. , Ossenkoppele, R. , Knol, D. L. , Tijms, B. M. , Scheltens, P. , Verhey, F. R. J. & Visser, P. J. (2015). Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. Journal of the American Medical Association (JAMA), 313 (19), 1924-1938. [BibTeX]
- Bloniecki, V. , Aarsland, D. , Cummings, J. , Blennow, K. & Freund-Levi, Y. (2014). Agitation in dementia: relation to core cerebrospinal fluid biomarker levels. Dementia and Geriatric Cognitive Disorders Extra, 4 (2), 335-43. [BibTeX]
- Freund-Levi, Y. , Vedin, I. , Hjorth, E. , Basun, H. , Faxén Irving, G. , Schultzberg, M. , Eriksdotter, M. , Palmblad, J. & et al. (2014). Effects of supplementation with omega-3 fatty acids on oxidative stress and inflammation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 42 (3), 823-831. [BibTeX]
- Freund-Levi, Y. , Bloniecki, V. , Auestad, B. , Tysen Bäckström, A. C. , Lärksäter, M. & Aarsland, D. (2014). Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study. Dementia and Geriatric Cognitive Disorders, 38 (3-4), 234-244. [BibTeX]
- Freund-Levi, Y. , Jedenius, E. , Tysen-Bäckström, A. C. , Lärksäter, M. , Wahlund, L. & Eriksdotter, M. (2014). Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial. The American journal of geriatric psychiatry, 22 (4), 341-248. [BibTeX]
- Holmgren, S. , Hjorth, E. , Schultzberg, M. , Lärksäter, M. , Frenkel, D. , Tysen-Bäckström, A. C. , Aarsland, D. & Freund-Levi, Y. (2014). Neuropsychiatric symptoms in dementia: a role for neuroinflammation?. Brain Research Bulletin, 108, 88-93. [BibTeX]
- Freund-Levi, Y. , Jedenius, E. , Wahlund, L. , Eriksdotter, M. , Tysen-Bäckström, A. C. & Lärksäter, M. (2014). Response to Bogaiksy's Letter to the Editor. The American journal of geriatric psychiatry, 22 (9), 951-951. [BibTeX]
- Freund-Levi, Y. , Vedin, I. , Cederholm, T. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Hjorth, E. , Schultzberg, M. & et al. (2014). Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. Journal of Internal Medicine, 275 (4), 428-436. [BibTeX]
- Faxén-Irving, G. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Hjorth, E. , Palmblad, J. , Vedin, I. , Cederholm, T. & et al. (2013). Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 36 (1), 1-6. [BibTeX]
- Forsberg, A. , Juréus, A. , Cselényi, Z. , Eriksdotter, M. , Freund-Levi, Y. , Jeppsson, F. , Swahn, B. , Sandell, J. & et al. (2013). Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients. European Journal of Nuclear Medicine and Molecular Imaging, 40 (4), 580-593. [BibTeX]
- Hjorth, E. , Zhu, M. , Toro, V. C. , Vedin, I. , Palmblad, J. , Cederholm, T. , Freund-Levi, Y. , Faxen-Irving, G. & et al. (2013). Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. Journal of Alzheimer's Disease, 35 (4), 697-713. [BibTeX]
- Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Irving, G. F. , Eriksdotter-Jönhagen, M. , Wahlund, L. & et al. (2012). Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLOS ONE, 7 (4). [BibTeX]
- Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Hjorth, E. , Faxén Irving, G. , Eriksdotter-Jönhagen, M. , Schultzberg, M. & et al. (2010). Reduced prostaglandin F-2 alpha release from blood mononuclear leukocytes after oral supplementation of omega 3 fatty acids: the OmegAD study. Journal of Lipid Research, 51 (5), 1179-1185. [BibTeX]
- Fjellström, C. , Starkenberg, Å. , Wesslén, A. , Tysén Bäckstrom, A. , Faxén-Irving, G. , The OmegAD Study group, . & Freund-Levi, Y. (2010). To Be a Good Food Provider: An Exploratory Study Among Spouses of Persons With Alzheimer's Disease. American Journal of Alzheimer’s Disease and Other Dementia, 25 (6), 521-526. [BibTeX]
- Nyberg, S. , Eriksdotter Jönhagen, M. , Cselényi, Z. , Halldin, C. , Julin, P. , Olsson, H. , Freund-Levi, Y. , Andersson, J. & et al. (2009). Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. European Journal of Nuclear Medicine and Molecular Imaging, 36 (11), 1859-1863. [BibTeX]
- Freund-Levi, Y. , Hjorth, E. , Lindberg, C. , Cederholm, T. , Faxen-Irving, G. , Vedin, I. , Palmblad, J. , Wahlund, L. & et al. (2009). Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study. Dementia and Geriatric Cognitive Disorders, 27 (5), 481-490. [BibTeX]
- Irving, G. F. & Freund-Levi, Y. (2009). Erratum: Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: The omega-3 Alzheimer's disease study (Journal of the American Geriatrics Society (2009) 57 (11-17)). Journal of The American Geriatrics Society, 57 (3), 579-579. [BibTeX]
- Irving, G. F. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Brismar, K. , Hjorth, E. , Palmblad, J. , Vessby, B. & et al. (2009). Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. Journal of The American Geriatrics Society, 57 (1), 11-17. [BibTeX]
- Visser, P. J. , Verhey, F. , Knol, D. L. , Scheltens, P. , Wahlund, L. , Freund-Levi, Y. , Tsolaki, M. , Minthon, L. & et al. (2009). Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurology, 8 (7), 619-627. [BibTeX]
- Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Faxén Irving, G. , Jönhagen, M. E. , Vessby, B. & et al. (2008). Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 87 (6), 1616-1622. [BibTeX]
- Freund-Levi, Y. , Basun, H. , Cederholm, T. , Faxén-Irving, G. , Garlind, A. , Grut, M. , Vedin, I. , Palmblad, J. & et al. (2008). Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. International Journal of Geriatric Psychiatry, 23 (2), 161-169. [BibTeX]
- Palmblad, J. , Eriksdotter-Jönhagen, M. , Freund-Levi, Y. & Cederholm, T. (2007). [Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited]. Läkartidningen, 104 (44), 3268-3271. [BibTeX]
- Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Cederholm, T. , Basun, H. , Faxén-Irving, G. , Garlind, A. , Vedin, I. , Vessby, B. & et al. (2006). Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study - A randomized double-blind trial. Archives of Neurology, 63 (10), 1402-1408. [BibTeX]
- Nordberg, A. , Eriksdotter-Jönhagen, M. , Garlind, A. , Grut, M. , Freund-Levi, Y. , Cornelius, C. , Ekström, A. , Fastbom, J. & et al. (2006). Värt ge symtomlindrande läkemedel vid Alzheimers sjukdom [Administration of symptom-relieving drugs in Alzheimer disease is beneficial]. Läkartidningen, 103 (6), 369-371. [BibTeX]
Artiklar, forskningsöversikter
- Bateman, D. R. , Sascha, G. , Hu, S. , Foster, E. D. , Ruthirakuhan, M. T. , Sellek, A. F. , Mortby, M. E. , Matušková, V. & et al. (2020). Agitation and impulsivity in mid and late life as possible riskmarkers for incident dementia. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 6 (1). [BibTeX]
- Shlisky, J. , Bloom, D. E. , Beaudreault, A. R. , Tucker, K. L. , Keller, H. H. , Freund-Levi, Y. , Fielding, R. A. , Cheng, F. W. & et al. (2017). Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease. Advances in Nutrition, 8 (1), 17-26. [BibTeX]
- Hjorth, E. & Freund-Levi, Y. (2012). Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid.. Current opinion in clinical nutrition and metabolic care, 15 (2), 134-143. [BibTeX]
Konferensbidrag
- Zhai, Q. , Freund-Levi, Y. , Horn, A. , Fridenberger, A. -. , Lager, E. , Montgomery, S. & Persson, J. (2021). Physical training for patients with depression and anxiety - a randomized controlled study. I: European psychiatry. Konferensbidrag vid 29th European Congress of Psychiatry (EPA Virtual 2021), April 10-13, 2021. (ss. S690-S690). Cambridge University Press. [BibTeX]
- Bloniecki, V. , Freund-Levi, Y. , Aarsland, D. & Blennow, K. (2012). Agitation - relation to clinical and dementia biomarkers in cerebrospinal fluid. I: European Journal of Neurology. Konferensbidrag vid 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Stockholm, SWEDEN, Sep 08-11, 2012. (ss. 112-112). Blackwell Publishing. [BibTeX]
- Vedin, I. , Cederholm, T. , Liden, J. , Freund-Levi, Y. , Palmblad, J. & OmegAD, S. G. (2004). Inflammatory gene expression changes by omega-3 fatty acids in patients with Alzheimer's disease. I: The FASEB Journal. Konferensbidrag vid Experimental Biology 2004 Meeting, Washington, DC, April 17-21, 2004. (ss. A501-A501). Federation of the American Societies for Experimental Biology. [BibTeX]
- Freund-Levi, Y. , Jonhagen, M. , Wahlund, L. , Basun, H. , Palmblad, J. & Cederholm, T. (2004). Safety and tolerability of omega-3 fatty acids in patients with Alzheimer's disease. I: Neurobiology of Aging. Konferensbidrag vid 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, PA, July 17-22, 2004. (ss. S471-S471). Elsevier. [BibTeX]
Manuskript
- Wesenhagen, K. E. J. , de Leeuw, D. M. , Tomassen, J. , Gobom, J. , Bos, I. , Vos, S. J. B. , Martinez-Lage, P. , Tainta, M. & et al. Synaptic protein CSF levels relate to memory scores in individuals without dementia.. [BibTeX]