Liza Ljungberg
Befattning: Universitetslektor Organisation: Institutionen för medicinska vetenskaperE-post: bGl6YS5sanVuZ2Jlcmc7b3J1LnNl
Telefon: 019 301477
Rum: X2213
Om Liza Ljungberg
Hjärtkärlsjukdomar, som t.ex. hjärtinfarkt och stroke är den ledande dödsorsaken i världen och står för 17 miljoner dödsfall varje år. De uppstår då aterosklerotiska plack rupturerar och orsakar obstruktion i kärlen vilket leder till brist på syre och näringsämnen i hjärta eller hjärna. Tidigare ansågs ateroskleros vara en passiv inlagring av lipider i kärlväggen, men på senare år har forskning visat att ateroskleros är en komplicerad process som involverar ett stort antal gener som aktiveras då sjukdomen utvecklas och fortskrider.
Jag studerar molekylära mekanismer involverade i utvecklingen av ateroskleros och trombos, samt hur olika vaskulära celler samverkar.
Forskningsprojekt
Pågående projekt
Forskargrupper
Publikationer
Artiklar i tidskrifter
- Hayderi, A. , Zegeye, M. M. , Meydan, S. , Sirsjö, A. , Kumawat, A. K. & Ljungberg, L. (2024). TNF Induces Laminin-332-Encoding Genes in Endothelial Cells and Laminin-332 Promotes an Atherogenic Endothelial Phenotype. International Journal of Molecular Sciences, 25 (16). [BibTeX]
- Zegeye, M. M. , Matic, L. , Lengquist, M. , Hayderi, A. , Grenegård, M. , Hedin, U. , Sirsjö, A. , Ljungberg, L. U. & et al. (2023). Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells. Atherosclerosis, 371, 41-53. [BibTeX]
- Zegeye, M. M. , Nakka, S. S. , Andersson, J. S. O. , Söderberg, S. , Ljungberg, L. , Kumawat, A. K. & Sirsjö, A. (2023). Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol. Journal of Molecular Medicine, 101 (12), 1615-1626. [BibTeX]
- Kumawat, A. K. , Zegeye, M. M. , Paramel Varghese, G. , Baumgartner, R. , Gisterå, A. , Amegavie, O. , Hellberg, S. , Jin, H. & et al. (2022). Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice. Frontiers in Cardiovascular Medicine, 9. [BibTeX]
- Lindkvist, M. , Zegeye, M. M. , Grenegård, M. & Ljungberg, L. (2022). Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells. International Journal of Molecular Sciences, 23 (3). [BibTeX]
- Zegeye, M. M. , Andersson, J. S. O. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study. Arteriosclerosis, Thrombosis and Vascular Biology, 41 (4), 1570-1579. [BibTeX]
- Paramel Varghese, G. , Karadimou, G. , Göthlin Eremo, A. , Ljungberg, L. , Hedin, U. , Olofsson, P. S. , Folkersen, L. , Paulsson Berne, G. & et al. (2020). Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Scientific Reports, 10 (1). [BibTeX]
- Ljungberg, L. , Zegeye, M. M. , Kardeby, C. , Fälker, K. , Repsilber, D. & Sirsjö, A. (2020). Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells. Mediators of Inflammation, 2020. [BibTeX]
- Zegeye, M. M. , Andersson, B. , Sirsjö, A. & Ljungberg, L. U. (2020). IL-6 trans-Signaling Impairs Sprouting Angiogenesis by Inhibiting Migration, Proliferation and Tube Formation of Human Endothelial Cells.. Cells, 9 (6). [BibTeX]
- Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cellular Signalling, 59, 96-109. [BibTeX]
- Lindkvist, M. , Fernberg, U. , Ljungberg, L. , Fälker, K. , Fernström, M. , Hurtig-Wennlöf, A. & Grenegård, M. (2019). Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults. Thrombosis Research, 174, 5-12. [BibTeX]
- Kardeby, C. , Fälker, K. , Haining, E. J. , Criel, M. , Lindkvist, M. , Barroso, R. , Påhlsson, P. , Ljungberg, L. & et al. (2019). Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. Blood Advances, 3 (3), 275-287. [BibTeX]
- Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1). [BibTeX]
- Donner, L. , Fälker, K. , Gremer, L. , Klinker, S. , Pagani, G. , Ljungberg, L. U. , Lothmann, K. , Rizzi, F. & et al. (2016). Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Science Signaling, 9 (429). [BibTeX]
- Ljungberg, L. U. , Östgren, C. J. , Nyström, F. H. & Länne, T. (2014). Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients. jraas. Journal of the renin-angiotensin-aldosterone system, 15 (1), 61-8. [BibTeX]
- Canaider, S. , Maioli, M. , Facchin, F. , Bianconi, E. , Santaniello, S. , Pigliaru, G. , Ljungberg, L. U. , Burigana, F. & et al. (2014). Human Stem Cell Exposure to Developmental Stage Zebrafish Extracts: a Novel Strategy for Tuning Stemness and Senescence Patterning. Cell, 2 (5). [BibTeX]
- Ljungberg, L. U. , Alehagen, U. , De Basso, R. , Persson, K. , Dahlström, U. & Länne, T. (2013). Circulating angiotensin-converting enzyme is associated with left ventricular dysfunction, but not with central aortic hemodynamics. International Journal of Cardiology, 166 (2), 540-1. [BibTeX]
- Ljungberg, L. U. , Persson, K. , Eriksson, A. C. , Green, H. & Whiss, P. A. (2013). Effects of nicotine, its metabolites and tobacco extracts on human platelet function in vitro. Toxicology in Vitro, 27 (2), 932-8. [BibTeX]
- Björck, H. M. , Eriksson, P. , Alehagen, U. , De Basso, R. , Ljungberg, L. U. , Persson, K. , Dahlström, U. & Länne, T. (2011). Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure. American Journal of Hypertension, 24 (7), 802-8. [BibTeX]
- Ljungberg, L. U. , De Basso, R. , Alehagen, U. , Björck, H. M. , Persson, K. , Dahlström, U. & Länne, T. (2011). Impaired abdominal aortic wall integrity in elderly men carrying the angiotensin-converting enzyme D allele. European Journal of Vascular and Endovascular Surgery, 42 (3), 309-16. [BibTeX]
- Ljungberg, L. U. , Alehagen, U. , Länne, T. , Björck, H. , De Basso, R. , Dahlström, U. & Persson, K. (2011). The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: a cross-sectional study.. jraas. Journal of the renin-angiotensin-aldosterone system, 12 (3), 281-9. [BibTeX]
- Ljungberg, L. U. & Persson, K. (2008). Effect of nicotine and nicotine metabolites on angiotensin-converting enzyme in human endothelial cells. Endothelium, 15 (5-6), 239-45. [BibTeX]
Artiklar, forskningsöversikter
- Biava, P. M. , Canaider, S. , Facchin, F. , Bianconi, E. , Ljungberg, L. , Rotilio, D. , Burigana, F. & Ventura, C. (2015). Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Current Pharmaceutical Biotechnology, 16 (9), 782-792. [BibTeX]
Konferensbidrag
- Hayderi, A. , Sirsjö, A. , Salihovic, S. & Ljungberg, L. (2023). Interferon gamma reprograms glutamine metabolic pathways in human aortic smooth muscle cells. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S8-S8). Elsevier. [BibTeX]
- Zegeye, M. , Ljungberg, L. , Nakka, S. , Andersson, J. , Söderberg, S. , Kumawat, A. & Sirsjö, A. (2023). Soluble LDL-receptor is induced by TNF-Α and inhibits hepatocytic clearance of LDL-cholesterol. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S61-S61). Elsevier. [BibTeX]
- Hayderi, A. , Ljungberg, L. , Kumawat, A. K. & Sirsjö, A. (2021). Function of viperin in human aortic SMCS and its relevance for atherosclerosis. I: Atherosclerosis. Elsevier. [BibTeX]
- Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hyderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses: Possible mechanism for immune cell recruitment during atherosclerosis?. I: Atherosclerosis. Elsevier. [BibTeX]
Manuskript
- Paramel Varghese, G. , Göthlin Eremo, A. , Ljungberg, L. , Sirsjö, A. & Fransén, K. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells. [BibTeX]
- Lindkvist, M. , Zegeye, M. M. , Sirsjö, A. , Grenegård, M. & Ljungberg, L. U. Comparative evaluation of gp130 signalling cytokines in human endothelial cells : evidence for both specific and overlapping molecular responses. [BibTeX]
- Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hayderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. U. IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses : possible mechanism for immune cell recruitment during atherosclerosis?. [BibTeX]
- Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets. [BibTeX]
- Hayderi, A. , Dunér, P. , Kumawat, A. K. , Överby, A. K. , Sirsjö, A. & Ljungberg, L. U. Impact of RSAD2 deficiency on atherosclerosisdevelopment in ApoE-/- mice. [BibTeX]
- Hayderi, A. , Salihovic, S. , Shavva, V. , Sirsjö, A. & Ljungberg, L. U. Interferon gamma induces perturbation in glutamine metabolism : insights from human smooth muscle cells and atherosclerotic lesions. [BibTeX]
- Zegeye, M. M. , Andersson, J. S. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. Interleukin-6 as a mediator of the association between traditional risk factors and future Myocardial Infarction : A nested case-control study. [BibTeX]
- Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?. [BibTeX]
- Kardeby, C. , Sirsjö, A. , Ljungberg, L. & Grenegård, M. Sulfated glycopolymers and polysaccharides regulate inflammation-related proteins in human vascular endothelial cells. [BibTeX]