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Allan Sirsjö

Befattning: Seniorprofessor Organisation: Institutionen för medicinska vetenskaper

E-post: YWxsYW4uc2lyc2pvO29ydS5zZQ==

Telefon: 019 301025

Rum: X2216

Forskningsämne

Biomedicin

Om Allan Sirsjö

Forskningsinriktning/aktuella projekt

Forskare inom Cardiovascular Research Centre (CVRC)

Uppdrag

Programansvarig: Mastersprogram, Biomedicin och metoder inom medicinsk diagnostik

Ämnesansvarig: Medicin

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter

Hayderi, A. , Kumawat, A. K. , Shavva, V. S. , Dreifaldt, M. , Sigvant, B. , Petri, M. , Kragsterman, B. , Olofsson, P. S. & et al. (2024). RSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells. Scientific Reports, 14 (1). [BibTeX]
Hayderi, A. , Zegeye, M. M. , Meydan, S. , Sirsjö, A. , Kumawat, A. K. & Ljungberg, L. (2024). TNF Induces Laminin-332-Encoding Genes in Endothelial Cells and Laminin-332 Promotes an Atherogenic Endothelial Phenotype. International Journal of Molecular Sciences, 25 (16). [BibTeX]
Thazhathveettil, J. , Kumawat, A. K. , Demirel, I. , Sirsjö, A. & Paramel Varghese, G. (2024). Vascular smooth muscle cells in response to cholesterol crystals modulates inflammatory cytokines release and promotes neutrophil extracellular trap formation. Molecular Medicine, 30 (1). [BibTeX]
Zegeye, M. M. , Matic, L. , Lengquist, M. , Hayderi, A. , Grenegård, M. , Hedin, U. , Sirsjö, A. , Ljungberg, L. U. & et al. (2023). Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells. Atherosclerosis, 371, 41-53. [BibTeX]
Zegeye, M. M. , Nakka, S. S. , Andersson, J. S. O. , Söderberg, S. , Ljungberg, L. , Kumawat, A. K. & Sirsjö, A. (2023). Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol. Journal of Molecular Medicine, 101 (12), 1615-1626. [BibTeX]
Kumawat, A. K. , Zegeye, M. M. , Paramel Varghese, G. , Baumgartner, R. , Gisterå, A. , Amegavie, O. , Hellberg, S. , Jin, H. & et al. (2022). Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice. Frontiers in Cardiovascular Medicine, 9. [BibTeX]
Zegeye, M. M. , Andersson, J. S. O. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study. Arteriosclerosis, Thrombosis and Vascular Biology, 41 (4), 1570-1579. [BibTeX]
Paramel Varghese, G. , Karadimou, G. , Göthlin Eremo, A. , Ljungberg, L. , Hedin, U. , Olofsson, P. S. , Folkersen, L. , Paulsson Berne, G. & et al. (2020). Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Scientific Reports, 10 (1). [BibTeX]
Ljungberg, L. , Zegeye, M. M. , Kardeby, C. , Fälker, K. , Repsilber, D. & Sirsjö, A. (2020). Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells. Mediators of Inflammation, 2020. [BibTeX]
Zegeye, M. M. , Andersson, B. , Sirsjö, A. & Ljungberg, L. U. (2020). IL-6 trans-Signaling Impairs Sprouting Angiogenesis by Inhibiting Migration, Proliferation and Tube Formation of Human Endothelial Cells.. Cells, 9 (6). [BibTeX]
Hedlund, M. , Thorlacius, G. E. , Ivanchenko, M. , Ottosson, V. , Kyriakidis, N. , Lagnefeldt, L. , Tingström, J. , Sirsjö, A. & et al. (2020). Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero. RMD Open, 6 (1). [BibTeX]
Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. (2019). A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. European Journal of Pharmacology, 857. [BibTeX]
Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α_2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cellular Signalling, 59, 96-109. [BibTeX]
Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1). [BibTeX]
Paramel Varghese, G. , Folkersen, L. , Strawbridge, R. J. , Halvorsen, B. , Yndestad, A. , Ranheim, T. , Krohg-Sørensen, K. , Skjelland, M. & et al. (2016). NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5 (5). [BibTeX]
Zhang, B. , Sirsjö, A. , Khalaf, H. & Bengtsson, T. (2016). Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis. Scientific Reports, 6. [BibTeX]
Zhang, B. , Khalaf, H. , Sirsjö, A. & Bengtsson, T. (2015). Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells. Infection and Immunity, 83 (11), 4256-4265. [BibTeX]
Paramel, G. , Uporova, L. , Halfvarson, J. , Sirsjö, A. & Fransén, K. (2015). Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease. Molecular Medicine Reports, 11 (6), 4579-4584. [BibTeX]
Bilbija, D. , Elmabsout, A. A. , Sagave, J. , Haugen, F. , Bastani, N. , Dahl, C. P. , Gullestad, L. , Sirsjö, A. & et al. (2014). Expression of retinoic acid target genes in coronary artery disease. International Journal of Molecular Medicine, 33 (3), 677-86. [BibTeX]
Basic, V. T. , Jacobsen, A. , Sirsjö, A. & Abdel-Halim, S. (2014). TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes. International Journal of Molecular Medicine, 34 (1), 228-236. [BibTeX]
Paramel, G. , Folkersen, L. , Strawbridge, R. J. , Elmabsout, A. , Särndahl, E. , Lundman, P. , Jansson, J. , Hansson, G. K. & et al. (2013). CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clinical Science, 125 (8), 401-407. [BibTeX]
Fransén, K. , Franzén, P. , Magnuson, A. , Elmabsout, A. , Nyhlin, N. , Wickbom, A. , Curman, B. , Törkvist, L. & et al. (2013). Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease. PLOS ONE, 8 (8), e72739. [BibTeX]
Paramel, G. , Fransén, K. , Hurtig-Wennlöf, A. , Bengtsson, T. , Jansson, J. & Sirsjö, A. (2013). Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomedical Reports, 1 (6), 879-882. [BibTeX]
Zhang, B. , Elmabsout, A. A. , Khalaf, H. , Basic, V. T. , Jayaprakash, K. , Kruse, R. , Bengtsson, T. & Sirsjö, A. (2013). The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. BMC Genomics, 14, 770. [BibTeX]
Krivospitskaya, O. , Elmabsout, A. A. , Sundman, E. , Söderström, L. A. , Ovchinnikova, O. , Gidlöf, A. C. , Scherbak, N. , Norata, G. D. & et al. (2012). A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis. Molecular Medicine, 18 (1), 712-718. [BibTeX]
Elmabsout, A. A. , Kumawat, A. K. , Saenz-Méndez, P. , Krivospitskaya, O. , Sävenstrand, H. , Olofsson, P. S. , Eriksson, L. A. , Strid, Å. & et al. (2012). Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells. PLOS ONE, 7 (5). [BibTeX]
Basic, V. T. , Tadele, E. , Elmabsout, A. A. , Yao, H. , Rahman, I. , Sirsjö, A. & Abdel-Halim, S. M. (2012). Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. American Journal of Physiology - Lung cellular and Molecular Physiology, 303 (6), L519-L527. [BibTeX]
Saenz-Méndez, P. , Elmabsout, A. A. , Sävenstrand, H. , Awadalla, M. K. A. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2012). Homology models of human all-trans-retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced-variant. Journal of Chemical Information and Modeling, 52 (10), 2631-2637. [BibTeX]
Bilbija, D. , Haugen, F. , Sagave, J. , Baysa, A. , Bastani, N. , Levy, F. O. , Sirsjö, A. , Blomhoff, R. & et al. (2012). Retinoic acid signalling is activated in the postischemic heart and may influence remodelling. PLOS ONE, 7 (9). [BibTeX]
Nixon Tangi, T. , Elmabsout, A. A. , Bengtsson, T. , Sirsjö, A. & Fransén, K. (2012). Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells. International Journal of Molecular Medicine, 30 (3), 697-702. [BibTeX]
Ocaya, P. A. , Elmabsout, A. A. , Olofsson, P. S. , Törmä, H. , Gidlöf, A. C. & Sirsjö, A. (2011). CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells. Journal of Vascular Research, 48 (1), 23-30. [BibTeX]
El Marghani, A. M. , Abuabaid, H. M. , Hurtig-Wennlöf, A. , Sirsjö, A. , Norgren, L. & Kjellén, P. (2010). High MAPK p38 activity and low level of IL-10 in intermittent claudication as opposed to stable angina. International Journal of Angiology, 29 (4), 331-337. [BibTeX]
Virtanen, M. , Sirsjö, A. , Vahlquist, A. & Torma, H. (2010). Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RAR alpha. Experimental dermatology, 19 (7), 674-681. [BibTeX]
Olofsson, P. S. , Sheikine, Y. , Jatta, K. , Ghaderi, M. , Samnegård, A. , Eriksson, P. & Sirsjö, A. (2009). A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development - The interleukin-1Î²: Interleukin-1 receptor antagonist balance in atherosclerosis. Circulation Journal, 73 (8), 1531-1536. [BibTeX]
Olofsson, P. S. , Söderström, L. Å. , Jern, C. , Sirsjö, A. , Ria, M. , Sundler, E. , De Faire, U. , Wiklund, P. G. & et al. (2009). Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. Journal of Molecular Medicine, 87 (4), 337-346. [BibTeX]
Jatta, K. , Eliason, G. , Portela-Gomes, G. M. , Grimelius, L. , Caro, O. , Nilholm, L. , Sirsjö, A. , Piehl-Aulin, K. & et al. (2009). Overexpression of von Hippel-Lindau protein in skeletal muscles of patients with chronic obstructive pulmonary disease. Journal of Clinical Pathology, 62 (1), 70-76. [BibTeX]
Olofsson, P. S. , Söderström, L. A. , Wågsäter, D. , Sheikine, Y. , Ocaya, P. , Lang, F. , Rabu, C. , Chen, L. & et al. (2008). CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation, 117 (10), 1292-1301. [BibTeX]
Karlsson, M. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2008). Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). Journal of Chemical Theory and Computation, 4 (6), 1021-1027. [BibTeX]
Ocaya, P. , Gidlöf, A. C. , Olofsson, P. S. , Törmä, H. & Sirsjö, A. (2007). CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 27 (7), 1542-1548. [BibTeX]
Uggla, B. , Tina, E. , Nahi, H. , Paul, C. , Höglund, M. , Sirsjö, A. & Tidefelt, U. (2007). Topoisomerase IIα mRNA and protein expression vs. in vitro drug resistance and clinical outcome in acute leukaemia. International Journal of Oncology, 31 (1), 153-160. [BibTeX]
Gidlöf, A. C. , Ocaya, P. , Olofsson, P. S. , Törmä, H. & Sirsjö, A. (2006). Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells. Journal of Vascular Research, 43 (4), 392-398. [BibTeX]
Hosseini, A. , Koskela, L. R. , Ehrén, I. , Aguilar-Santelises, M. , Sirsjö, A. & Wiklund, N. P. (2006). Enhanced formation of nitric oxide in bladder carcinoma in situ and in BCG treated bladder cancer. Nitric oxide, 15 (4), 337-343. [BibTeX]
Wågsäter, D. , Jatta, K. , Ocaya, P. , Dimberg, J. & Sirsjö, A. (2006). Expression of IL-1β, IL-1 receptor type I and IL-1 receptor antagonist in human aortic smooth muscle cells: effects of all-trans-retinoic acid. Journal of Vascular Research, 43 (4), 377-382. [BibTeX]
Uggla, B. , Ståhl, E. , Wågsäter, D. , Paul, C. , Karlsson, M. G. , Sirsjö, A. & Tidefelt, U. (2005). BCRP mRNA expression v. clinical outcome in 40 adult AML patients. Leukemia Research, 29 (2), 141-146. [BibTeX]
Jatta, K. , Wågsäter, D. , Norgren, L. , Stenberg, B. & Sirsjö, A. (2005). Lipopolysaccharide-induced cytokine and chemokine expression in human carotid lesions. Journal of Vascular Research, 42 (3), 266-271. [BibTeX]
Olofsson, P. , Jatta, K. , Wågsäter, D. , Gredmark, S. , Hedin, U. , Paulsson-Berne, G. , Söderberg-Nauclér, C. , Hansson, G. & et al. (2005). The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arteriosclerosis, Thrombosis and Vascular Biology, 25 (7), 113-116. [BibTeX]
Wuttge, D. M. , Zhou, X. , Sheikine, Y. , Wågsäter, D. , Stemme, V. , Hedin, U. , Stemme, S. , Hansson, G. K. & et al. (2004). CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions. Arteriosclerosis, Thrombosis and Vascular Biology, 24 (4), 750-755. [BibTeX]
Fransén, K. , Dimberg, J. , Österström, A. , Olsson, A. , Söderkvist, P. & Sirsjö, A. (2002). Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas. Surgery, 131 (4), 384-392. [BibTeX]

Artiklar, forskningsöversikter

Paramel, G. , Sirsjö, A. & Fransén, K. (2015). Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease. Mediators of Inflammation. [BibTeX]
Sheikine, Y. & Sirsjö, A. (2008). CXCL16/SR-PSOX: a friend or a foe in atherosclerosis?. Atherosclerosis, 197 (2), 487-495. [BibTeX]
Gidlöf, A. C. , Ocaya, P. , Krivospitskaya, O. & Sirsjö, A. (2008). Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?. Clinical Science, 114 (1), 19-25. [BibTeX]

Böcker

Athlin, S. , Berglind, Å. , Dahlberg, K. , Ehnfors, C. , Eklund, D. , Pettersson, C. , Rangel, I. , Rolland, A. & et al. Athlin, S. (ed.) , Berglind, Å. (ed.) , Dahlberg, K. (ed.) , Ehnfors, C. (ed.) , Eklund, D. (ed.) , Pettersson, C. (ed.) , Rangel, I. (ed.) , Rolland, A. (ed.) , Sirsjö, A. (ed.) & Venizelos, N. (ed.) (2019). Örebro University’s Nobel Day Festivities: Book of abstracts, 2019. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Ericsson, E. , Johansson, M. , Hjelmqvist, H. , Jendle, J. , Eriksson, M. , Karlsson, M. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ericsson, E. (ed.) , Johansson, M. (ed.) , Hjelmqvist, H. (ed.) , Jendle, J. (ed.) , Eriksson, M. (ed.) , Karlsson, M. (ed.) & Möller, M. (ed.) (2018). Örebro University’s Nobel Day Festivities: Book of abstracts, 2018. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Andersson, S. , Hjelmqvist, H. , Karlsson, M. , Ericsson, E. , Söderquist, B. , Eriksson, M. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Karlsson, M. (ed.) , Ericsson, E. (ed.) , Söderquist, B. (ed.) , Eriksson, M. (ed.) & Möller, M. (ed.) (2017). Örebro University’s Nobel Day Festivities: Book of abstracts, 2017. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Grenegård, M. , Karlsson, M. , Andersson, S. , Hjelmqvist, H. , Ericsson, E. , Kihlgren, A. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) , Karlsson, M. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Ericsson, E. (ed.) , Kihlgren, A. (ed.) & Söderquist, B. (ed.) (2016). Örebro University’s Nobel Day Festivities: Book of abstracts, 2016. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Grenegård, M. & Karlsson, M. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) & Karlsson, M. (ed.) (2015). Örebro University’s Nobel Day Festivities: Book of abstracts 2015. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Kihlgren, A. , Grenegård, M. , Möller, C. , Danermark, B. , Eriksson, C. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Kihlgren, A. (ed.) , Grenegård, M. (ed.) , Möller, C. (ed.) , Danermark, B. (ed.) , Eriksson, C. (ed.) , Ericsson, C. (ed.) & Kadi, F. (ed.) (2014). Örebro University’s Nobel Day Festivities: Book of abstracts 2014. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Nilsson, U. , Grenegård, M. , Eriksson, C. & Ericsson, C. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Nilsson, U. (ed.) , Grenegård, M. (ed.) , Eriksson, C. (ed.) & Ericsson, C. (ed.) (2013). Örebro University’s Nobel Day Festivities: Book of abstracts 2013. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. , Ljungqvist, O. & Nilsson, U. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) & Nilsson, U. (ed.) (2012). Örebro University’s Nobel Day Festivities: Book of abstracts, 2012. Örebro: Örebro universitet. [BibTeX]
Venizelos, N. , Sirsjö, A. & Hultgren Hörnquist, E. Venizelos, N. (ed.) , Sirsjö, A. (ed.) & Hultgren Hörnquist, E. (ed.) (2011). Örebro University’s Nobel Day Festivities: Book of abstracts, 2011. Örebro: Örebro universitet. [BibTeX]
Sirsjö, A. & Venizelos, N. Sirsjö, A. (ed.) & Venizelos, N. (ed.) (2009). Örebro University’s Nobel Day Festivities: Book of abstracts, 2009. Örebro: Örebro universitet. [BibTeX]

Konferensbidrag

Thazhathveettil, J. , Kumawat, A. , Demirel, I. , Sirsjö, A. & Paramel, G. (2023). Cholesterol crystals uptake in vascular smooth muscle cells modulates local immune responses. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S9-S9). Elsevier. [BibTeX]
Kurt, S. , Pirronello, F. , Reitsema, R. , Demirel, I. , Rangel, I. , Sirsjö, A. , Dreifaldt, M. & Kumawat, A. (2023). Increased proportion of circulating neutrophils with impaired phagocytosis capacity in patients with peripheral arterial disease. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S22-S22). Elsevier. [BibTeX]
Hayderi, A. , Sirsjö, A. , Salihovic, S. & Ljungberg, L. (2023). Interferon gamma reprograms glutamine metabolic pathways in human aortic smooth muscle cells. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S8-S8). Elsevier. [BibTeX]
Pirronello, F. , Kurt, S. , Reitsema, R. , Rangel, I. , Dreifaldt, M. , Sirsjö, A. & Kumawat, A. (2023). Phenotypic and functional characterization of T cell immune responses in peripheral arterial disease. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S25-S25). Elsevier. [BibTeX]
Zegeye, M. , Ljungberg, L. , Nakka, S. , Andersson, J. , Söderberg, S. , Kumawat, A. & Sirsjö, A. (2023). Soluble LDL-receptor is induced by TNF-Α and inhibits hepatocytic clearance of LDL-cholesterol. I: Atherosclerosis. Konferensbidrag vid 91st Annual Meeting of the European-Atherosclerosis-Society (EAS 2023), Mannheim, Germany, May 21-24, 2023. (ss. S61-S61). Elsevier. [BibTeX]
Hayderi, A. , Ljungberg, L. , Kumawat, A. K. & Sirsjö, A. (2021). Function of viperin in human aortic SMCS and its relevance for atherosclerosis. I: Atherosclerosis. Elsevier. [BibTeX]
Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hyderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses: Possible mechanism for immune cell recruitment during atherosclerosis?. I: Atherosclerosis. Elsevier. [BibTeX]
Fransén, K. , Paramel Varghese, G. , Jansson, J. , Eriksson, P. & Sirsjö, A. (2016). Molecular genetic aspects of the NLRP3 inflammasome in cardiovascular disease. Konferensbidrag vid Miami Winter symposium 2016, Miami, Florida, USA, 24-27 Jan., 2016. [BibTeX]
Elmabsout, A. , Kumawat, A. K. , Karlsson, M. , Krivospitskaya, O. , Sävenstrand, H. , Hans, T. , Strid, Å. , Eriksson, L. A. & et al. (2010). Cloning and functional studies of a splice variant of CYP26B1: a cellular storage protein for all-trans retinoic acid. I: In Vivo. [BibTeX]
Johansson, J. , Vumma, R. , Sirsjö, A. & Venizelos, N. (2010). Interleukin-1beta inhibits tyrosine transport in fibroblasts from patients with schizophrenia and healthy controls. I: In Vivo. Konferensbidrag vid The 3rd Swedish-Hellenic Life Sciences Research Conference, Athens, March 25-27, 2010. (ss. 365-367). International Institute of Anticancer Research. [BibTeX]

Manuskript

Wågsäter, D. , Jatta, K. , Ocaya, P. , Dimberg, J. & Sirsjö, A. Expression of IL-1b, IL-1R1 I and IL-1Ra in human aortic smooth muscle cells : effects of all-trans retinoic acid. [BibTeX]
Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. [BibTeX]
Paramel Varghese, G. , Göthlin Eremo, A. , Ljungberg, L. , Sirsjö, A. & Fransén, K. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells. [BibTeX]
Basic, V. T. , Tadele, E. , Jacobsen, A. , Sirsjö, A. & Abdel-Halim, S. M. Chronic cigarette smoke exposureimpairs skeletal muscle regenerative capacity in murineCOPD/emphysema model.. [BibTeX]
Basic, V. T. , Jacobsen, A. , Tadele, E. , Banjop- Kharlyngdoh, J. , Sirsjö, A. & Abdel-Halim, S. M. Cigarette smoke exposure up-regulates Ubiquitin specific protease 19 in murine skeletal muscles as an adaptive response to prolonged ER stress. [BibTeX]
Lindkvist, M. , Zegeye, M. M. , Sirsjö, A. , Grenegård, M. & Ljungberg, L. U. Comparative evaluation of gp130 signalling cytokines in human endothelial cells : evidence for both specific and overlapping molecular responses. [BibTeX]
Lindkvist, M. , Paramel Varghese, G. , Göthlin Eremo, A. , Haque, A. , Rydberg Millrud, C. , Rattik, S. , Grönberg, C. , Liberg, D. & et al. IL-1RAP expression in human atherosclerosis : a future target of novel antibodies to reduce vascular adhesion and inflammation?. [BibTeX]
Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hayderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. U. IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses : possible mechanism for immune cell recruitment during atherosclerosis?. [BibTeX]
Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets. [BibTeX]
Hayderi, A. , Dunér, P. , Kumawat, A. K. , Överby, A. K. , Sirsjö, A. & Ljungberg, L. U. Impact of RSAD2 deficiency on atherosclerosisdevelopment in ApoE-/- mice. [BibTeX]
Hayderi, A. , Salihovic, S. , Shavva, V. , Sirsjö, A. & Ljungberg, L. U. Interferon gamma induces perturbation in glutamine metabolism : insights from human smooth muscle cells and atherosclerotic lesions. [BibTeX]
Zegeye, M. M. , Andersson, J. S. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. Interleukin-6 as a mediator of the association between traditional risk factors and future Myocardial Infarction : A nested case-control study. [BibTeX]
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?. [BibTeX]
Elmabsout, A. A. , Fransén, K. , Sundman, E. , Karikas, G. , Törmä, H. , Olofsson, P. S. & Sirsjö, A. Simvastatin and rosuvastatin inhibit CYP26B1-mediated retinoid catabolism. [BibTeX]
Kardeby, C. , Sirsjö, A. , Ljungberg, L. & Grenegård, M. Sulfated glycopolymers and polysaccharides regulate inflammation-related proteins in human vascular endothelial cells. [BibTeX]
Zhang, B. , Sirsjö, A. , Khalaf, H. & Bengtsson, T. Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis. [BibTeX]

Patent

Eriksson, L. A. , Sirsjö, A. & Strid, Å. (2019). Tetrazole derivatives as cytochrome p450 inhibitors . [BibTeX]