Mapping signal transduction in inflammation (Umbrella project)

Aim:
To create a detailed mechanistic network model of the cellular signalling processes controlling inflammation.

Background:
Inflammation is controlled by cellular signal transduction pathways: Sentinel cells monitor their surrounding (and themselves) for molecular signs of infection and/or damage, which triggers both intracellular responses and extracellular signal to other cells. Mapping the current knowledge of these processes is the first step towards understanding the control of inflammation.

Outcomes:
Detailed molecular knowledge is encoded in mechanistic network models that constitute “wiring-diagrams” of the signalling processes in the cell, providing a basis for computational prediction of system level function as well as a scaffold of integration and interpretation of data.

Status: Umbrella project encompassing multiple parallel projects. One project, on the NLRP3 inflammasome, is finalised and disseminated. Other projects, e.g. on TLR4 signalling and urinary tract infection and on NLRP1/CARD8 signalling, are ongoing.

The project owner is X-HiDE - Örebro University (oru.se)

Contact: X-HiDE@oru.se