ADAPTide: decrypting sustainable and responsive nutrition by mapping the effects of plant-based foods on metabolic profiling

What we eat has a significant impact on the environment. That's mainly because food habits strongly influence food production, directly impacting the ecosystem. Identifying healthy diets that are in harmony with a balanced environment and that consider the individual human metabolism is essential since there is no "one size fits all" approach to the effects of diet on health. Eating less meat can promote extensive environmental benefits, and there is already a broad awareness of it. Yet, we know little about to what extent adapting our diet affects human health. ADAPTide aims to decrypt individual human responses to plant-based foods by mapping diet- and gut-related metabolic profiling. Hence, we will investigate the effects of specific plant-based compounds (peptides, fibres, metabolites) that trigger human biological functions by associating them with human metabolome and gut microbiota profiling obtained from dietary interventions. Including digesta obtained from ileostomy participants and interventions with plant-based food products. We are using several different techniques including metabolomics, peptidomics, metagenomics of faeces, cell culture and in vivo and ex vivo models, among others.

This project includes multiple tools and approaches, including start-of-the-art equipment for peptidomics and metabolomics (UHPLC/QTOF-MS, UHPLC-QqQ-MS). In addition, we are located at the core facility for lifestyle intervention studies at Örebro hospital, facilitating the performance of clinical studies. These results will further advance the knowledge of targeting surrogate markers to assess individualized-tailored responsive and sustainable nutrition.