Publications

Julia König, María Fernanda Roca Rubio, Richard A Forsgård, Julia Rode, Jakob Axelsson , Gianfranco Grompone, Robert J Brummer. The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT. PLoS One. 2024 Nov 1;19(11):e0312464

Lina Tingö, Cecilia Bergh, Julia Rode, Maria Fernanda Roca Rubio, Jonas Persson, Linnea Brengesjö Johnson, Lotte H Smit, Ashley N Hutchinson. The Effect of Whole-Diet Interventions on Memory and Cognitive Function in Healthy Older Adults - A Systematic Review. Adv Nutr. 2024 Sep;15(9):100291

Julia Rode, Linnea Brengesjö Johnson, Julia König, Ignacio Rangel, Lars Engstrand, Dirk Repsilber, Robert J Brummer. Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota. Gut Microbes. 2024 Jan-Dec;16(1):2416912

Maria Fernanda Roca Rubio, Mattias Folkesson, Carolin Kremp, Niklas Evertsson, Dirk Repsilber, Ulrika Eriksson, John-Peter Ganda Mall, Fawzi Kadi, Robert J. Brummer, Julia König. Associations between various markers of intestinal barrier and immune function after a high-intensity exercise challenge. Physiol Rep. 2024 May;12(10):e16087.

Vingeliene, S. , Hiyoshi, A. , Lentjes, M. , Brummer, R. J. , Fall, K. & Montgomery, S. (2024). Hospital-treated infections and subsequent Parkinson's disease risk: a register-based sibling comparison study. Brain Communications, 6 (2).

Garcia-Argibay M, Hiyoshi A, Fall K, Montgomery S. Association between dementia risk and ulcerative colitis, with and without colectomy: a Swedish population-based register study. BMJ Open 2023; 13: e074110.

Forsgård, R. A. , Rode, J. , Lobenius Palmér, K. , Kamm, A. , Patil, S. , Tacken, M. G. J. , Lentjes, M. A. H. , Axelsson, J. & et al. (2023). Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial. Gut microbes, 15 (1).

Kopp, L. , Schweinlin, A. , Tingö, L. , Hutchinson, A. N. , Feit, V. , Jähnichen, T. , Lehnert, K. , Vetter, W. & et al. (2023). Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial. International Journal of Molecular Sciences, 24 (10).

Garcia-Argibay M, Hiyoshi A, Montgomery S. Acute appendicitis and ulcerative colitis: a population-based sibling comparison study. BMJ Open Gastroenterology 2022; 9: e001041.

Bachmann, R. , Van Hul, M. , Baldin, P. , Léonard, D. , Delzenne, N. M. , Belzer, C. , Ouwerkerk, J. P. , Repsilber, D. & et al. (2022). Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism. Cells, 11 (17).

Stenberg, R. , Brummer, R. J. & Norén, T. (2022). Faecal transplantation in a 2-year-old child with therapy-resistant Clostridiodes difficile infection. Acta Paediatrica, 111 (8), 1628-1629.

Fart, F. , Tingö, L. , Engelheart, S. , Lindqvist, C. M. , Brummer, R. J. , Kihlgren, A. & Schoultz, I. (2022). Gut Health and Its Association with Wellbeing and Nutrient Intake in Community-Dwelling Older Adults. Gastroenterology Insights, 13 (4), 349-364.

Rode, J. , Edebol Carlman, H. M. T. , König, J. , Hutchinson, A. , Thunberg, P. , Persson, J. & Brummer, R. J. (2022). Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT. Cells, 11 (18).

Tingö, L. , Hutchinson, A. N. , Bergh, C. , Stiefvatter, L. , Schweinlin, A. , Jensen, M. G. , Krüger, K. , Bischoff, S. C. & et al. (2022). Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation-A Randomized, Placebo-Controlled Trial. Nutrients, 14 (19).

Edebol Carlman, H. M. T. , Rode, J. , König, J. , Repsilber, D. , Hutchinson, A. , Thunberg, P. , Persson, J. , Kiselev, A. & et al. (2022). Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses to an Arithmetic Stress Task in Healthy Subjects: A Randomised Clinical Trial and Proof-of-Concept Study. Nutrients, 14 (7).

Rode, J. , Edebol Carlman, H. M. T. , König, J. , Repsilber, D. , Hutchinson, A. , Thunberg, P. , Andersson, P. , Persson, J. & et al. (2022). Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial. Frontiers in nutrition, 9.

Engel, S. , Mortensen, B. , Wellejus, A. , Vera-Jimenez, N. , Struve, C. , Brummer, R. J. , Damholt, A. , Woods, T. & et al. (2022). Safety of Bifidobacterium breve, Bif195, employing a human exercise-induced intestinal permeability model: a randomised, double-blinded, placebo-controlled, parallel group trial. Beneficial Microbes, 13 (3), 243-252.

Xu Y, Hiyoshi A, Brand JS, Smith KA, Bahmanyar S, Alfredsson L, Olsson T, Montgomery S. Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men. Multiple Sclerosis Journal 2021; 27: 147-150.

Rode, J. , Yang, L. , König, J. , Hutchinson, A. , Wall, R. , Venizelos, N. , Brummer, R. J. , Rangel, I. & et al. (2021). Butyrate Rescues Oxidative Stress-Induced Transport Deficits of Tryptophan: Potential Implication in Affective or Gut-Brain Axis Disorders. Neuropsychobiology, 80 (3), 253-263.

Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , de Vos, W. M. & et al. (2021). Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. Beneficial Microbes, 12 (1), 17-30.

Hutchinson AN, Bergh C, Kruger K, Sűsserová M, Allen J, Améen S, Tingö L. The Effect of Probiotics on Health Outcomes in the Elderly: A Systematic Review of Randomized, Placebo-Controlled Studies. Microorganisms. 2021 Jun 21;9(6):1344. doi: 10.3390/microorganisms9061344. PMID: 34205818; PMCID: PMC8234958.

Engelheart, S. , Bertéus Forslund, H. , Brummer, R. J. & Ljungqvist, O. (2021). Dehydration and loss of appetite: Key nutrition features in older people receiving home health care. Nutrition (Burbank, Los Angeles County, Calif.), 91-92.

Sabet, J. A. , Ekman, M. S. , Lundvall, A. S. , Risérus, U. , Johansson, U. , Öström, Å. , Adamsson, V. , Cao, Y. & et al. (2021). Feasibility and Acceptability of a Healthy Nordic Diet Intervention for the Treatment of Depression: A Randomized Controlled Pilot Trial. Nutrients, 13 (3).

Engelheart, S. , Andrén, D. , Repsilber, D. , Bertéus Forslund, H. & Brummer, R. J. (2021). Nutritional status in older people: An explorative analysis. Clinical Nutrition ESPEN, 46, 424-433.

Roca Rubio, M. F. , Eriksson, U. , Brummer, R. J. & König, J. (2021). Sauna dehydration as a new physiological challenge model for intestinal barrier function. Scientific Reports, 11 (1).

Roca Rubio, M. F. , Eriksson, U. , Brummer, R. J. & König, J. (2021). Short intense psychological stress induced by skydiving does not impair intestinal barrier function. PLOS ONE, 16 (7).

Baunwall, S. M. D. , Terveer, E. M. , Dahlerup, J. F. , Erikstrup, C. , Arkkila, P. , Vehreschild, M. J. , Ianiro, G. , Gasbarrini, A. & et al. (2021). The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey. The Lancet Regional Health: Europe, 9.

Tabat, M. W. , Marques, T. M. , Markgren, M. , Löfvendahl, L. , Brummer, R. J. & Wall, R. (2020). Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues. Biomolecules, 10 (5).

Fart, F. , Rajan, S. K. , Wall, R. , Rangel, I. , Ganda Mall, J. P. , Tingö, L. , Brummer, R. J. , Repsilber, D. & et al. (2020). Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults. Nutrients, 12 (9).

Ganda Mall, J. P. , Fart, F. , Sabet, J. A. , Lindqvist, C. M. , Nestestog, R. , Hegge, F. T. , Keita, Å. V. , Brummer, R. J. & et al. (2020). Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients, 12 (7).

Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Veress, G. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. (2020). Faecal microbiota transfer in patients with microscopic colitis: a pilot study in collagenous colitis. Scandinavian Journal of Gastroenterology, 55 (12), 1454-1466.

König, J. & Brummer, R. J. (2020). Faecal microbiota transplantation in IBS: new evidence for success?. Nature Reviews. Gastroenterology & Hepatology, 17 (4), 199-200.

Engelheart, S. , Brummer, R. J. & Forslund, H. B. (2020). Meal patterns in relation to energy and protein intake in older adults in home health care. Clinical Nutrition ESPEN, 35, 180-187.

Larsen, O. F. A. , Claassen, E. & Brummer, R. J. (2020). On the importance of intraindividual variation in nutritional research. Beneficial Microbes, 11 (6), 511-517.
Hutchinson, A. , Östlund-Lagerström, L. & Brummer, R. J. (2020). The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation. Nutrients, 12 (8).

Holster, S. , Hooiveld, G. J. , Repsilber, D. , de Vos, W. , Brummer, R. J. & König, J. (2019). Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome. Biomolecules, 9 (10).

Rajan, S. K. , Lindqvist, C. M. , Brummer, R. J. , Schoultz, I. & Repsilber, D. (2019). Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method. PLOS ONE, 14 (9).

Holster, S. , Lindqvist, C. M. , Repsilber, D. , Salonen, A. , de Vos, W. , König, J. & Brummer, R. J. (2019). The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study. Clinical and Translational Gastroenterology, 10 (4).

Sandgren, A. M. & Brummer, R. J. (2018). ADHD-originating in the gut?: The emergence of a new explanatory model. Medical Hypotheses, 120, 135-145.

Ganda Mall, J. , Östlund-Lagerström, L. , Lindqvist, C. M. , Algilani, S. , Rasoal, D. , Repsilber, D. , Brummer, R. J. , V. Keita, Å. & et al. (2018). Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?. BMC Geriatrics, 18 (1).

Engelheart, S. & Brummer, R. J. (2018). Assessment of nutritional status in the elderly: a proposed function-driven model. Food & Nutrition Research, 62.

Edebol-Carlman, H. , Schrooten, M. G. S. , Ljóttson, B. , Boersma, K. , Linton, S. J. & Brummer, R. J. (2018). Cognitive behavioral therapy for irritable bowel syndrome: the effects on state and trait anxiety and the autonomic nervous system during induced rectal distensions - An uncontrolled trial. Scandinavian Journal of Pain, 18, 81-91.

Ganda Mall, J. P. , Löfvendahl, L. , Lindqvist, C. M. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. (2018). Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms. Scientific Reports, 8 (1).

König, J. & Brummer, R. J. (2018). Is an enzyme supplement for celiac disease finally on the cards?. Expert Review of Gastroenterology & Hepatology, 12 (6), 531-533.
Zeilstra, D. , Younes, J. A. , Brummer, R. J. & Kleerebezem, M. (2018).

Perspective: Fundamental Limitations of the Randomized Controlled Trial Method in Nutritional Research: The Example of Probiotics. Advances in Nutrition, 9 (5), 561-571.

Montiel Rojas, D. , Nilsson, A. , Ponsot, E. , Brummer, R. J. , Fairweather-Tait, S. , Jennings, A. , de Groot, L. C. P. G. M. , Berendsen, A. & et al. (2018). Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults. Frontiers in Physiology, 9.

Mohajeri, M. H. , Brummer, R. J. , Rastall, R. A. , Weersma, R. K. , Harmsen, H. J. M. , Faas, M. & Eggersdorfer, M. (2018). The role of the microbiome for human health: from basic science to clinical applications. European Journal of Nutrition, 57 (Suppl. 1), S1-S14.

Ganda Mall, J. , Casado-Bedmar, M. , Winberg, M. E. , Brummer, R. J. , Schoultz, I. & Keita, Å. V. (2017). A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects. Inflammatory Bowel Diseases, 24 (1), 166-178.

Edebol-Carlman, H. , Ljotsson, B. , Linton, S. J. , Boersma, K. , Schrooten, M. , Repsilber, D. & Brummer, R. J. (2017). Face-to-Face Cognitive-Behavioral Therapy for Irritable Bowel Syndrome: The Effects on Gastrointestinal and Psychiatric Symptoms. Gastroenterology Research and Practice.

Wells, J. M. , Brummer, R. J. , Derrien, M. , MacDonald, T. T. , Troost, F. , Cani, P. D. , Theodorou, V. , Dekker, J. & et al. (2017). Homeostasis of the Gut Barrier and Potential Biomarkers. American Journal of Physiology - Gastrointestinal and Liver Physiology, 312 (3), G171-G193.

Hiyoshi, A. , Sabet, J. A. , Sjöqvist, H. , Melinder, C. , Brummer, R. J. & Montgomery, S. (2017). Precursors in adolescence of adult-onset bipolar disorder. Journal of Affective Disorders, 218, 353-358.

König, J. , Holster, S. , Maaike, B. & Brummer, R. J. (2017). Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting. Scientific Reports, 7 (13100).

Boersma, K. , Ljótsson, B. , Edebol-Carlman, H. , Schrooten, M. , Linton, S. J. & Brummer, R. J. (2016). Exposure-based cognitive behavioral therapy for irritable bowel syndrome: A single-case experimental design across 13 subjects. Cognitive Behaviour Therapy, 45 (6), 415-430.

Algilani, S. , Östlund-Lagerström, L. , Schoultz, I. , Brummer, R. J. & Kihlgren, A. (2016). Increasing the qualitative understanding of optimal functionality in older adults: a focus group based study. BMC Geriatrics, 16 (1).

Östlund-Lagerström, L. , Kihlgren, A. , Repsilber, D. , Björkstén, B. , Brummer, R. J. & Schoultz, I. (2016). Probiotic administration among free-living older adults: a double blinded, randomized, placebo-controlled clinical trial. Nutrition Journal, 15.

Sundin, J. , Rangel, I. , Fuentes, S. , Jong, H. , Hultgren-Hörnquist, E. , de Vos, W. M. & Brummer, R. (2015). Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress. Alimentary Pharmacology and Therapeutics, 41 (4), 342-351.

Sundin, J. , Rangel, I. , Repsilber, D. & Brummer, R. (2015). Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls. PLOS ONE, 10 (9).

Melinder, C. , Udumyan, R. , Hiyoshi, A. , Brummer, R. J. & Montgomery, S. (2015). Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease: a prospective study of 233 093 men in Sweden. Alimentary Pharmacology and Therapeutics, 41 (10), 1005-1015.

van den Nieuwboer, M. , Brummer, R. J. , Guarner, F. , Morelli, L. , Cabana, M. & Claassen, E. (2015). Safety of probiotics and synbiotics in children under 18 years of age. Beneficial Microbes, 6 (5), 615-630.

Östlund-Lagerström, L. , Blomberg, K. , Algilani, S. , Schoultz, M. , Kihlgren, A. , Brummer, R. J. & Schoultz, I. (2015). Senior orienteering athletes as a model of healthy aging: a mixed-method approach. BMC Geriatrics, 15.

Van den Nieuwboer, M. , Brummer, R. J. , Guarner, F. , Morelli, L. , Cabana, M. & Claassen, E. (2015). The administration of probiotics and synbiotics in immune compromised adults: is it safe?. Beneficial Microbes, 6 (1), 3-17.

Rangel, I. , Sundin, J. , Fuentes, S. , Repsilber, D. , de Vos, W. M. & Brummer, R. J. (2015). The relationship between faecal-associated and mucosal-associated microbiota in irritable bowel syndrome patients and healthy subjects. Alimentary Pharmacology and Therapeutics, 42 (10), 1211-1221.

Sundin, J. , Rangel, I. , Kumawat, A. K. , Hultgren-Hörnquist, E. & Brummer, R. J. (2014). Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scandinavian Journal of Gastroenterology, 49 (9), 1068-1075.

Santoro, A. , Pini, E. , Scurti, M. , Palmas, G. , Berendsen, A. , Brzozowska, A. , Pietruszka, B. , Szczecinska, A. & et al. (2014). Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design. Mechanisms of Ageing and Development, 136-137, 3-13.

van den Nieuwboer, M. , Claassen, E. , Morelli, L. , Guarner, F. & Brummer, R. J. (2014). Probiotic and synbiotic safety in infants under two years of age. Beneficial Microbes, 5 (1), 45-60.

Rossi, O. , Karczewski, J. , Stolte, E. H. , Brummer, R. J. M. , van Nieuwenhoven, M. A. , Meijerink, M. , van Neerven, J. R. J. , van Ijzendoorn, S. C. D. & et al. (2013). Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1. BMC research notes, 6, 431.

Vanhoutvin, S. A. L. W. , Troost, F. J. , Kilkens, T. O. C. , Lindsey, P. J. , Jonkers, D. M. A. E. , Venema, K. , Masclee, A. & Brummer, R. J. (2012). Alternative procedure to shorten rectal barostat procedure for the assessment of rectal compliance and visceral perception: a feasibility study. Journal of gastroenterology, 47 (8), 896-903.

Veereman-Wauters, G. , Staelens, S. , Rombaut, R. , Dewettinck, K. , Deboutte, D. , Brummer, R. , Boone, M. & Le Ruyet, P. (2012). Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children. Nutrition (Burbank, Los Angeles County, Calif.), 28 (7-8), 749-752.

Schepens, M. A. A. , ten Bruggencate, S. J. M. , Schonewille, A. J. , Brummer, R. , van der Meer, R. & Bovee-Oudenhoven, I. M. J. (2012). The protective effect of supplemental calcium on colonic permeability depends on a calcium phosphate-induced increase in luminal buffering capacity. British Journal of Nutrition, 107 (7), 950-956.