Publications

Anna Niarakis, Reinhard Laubenbacher, Gary An,..Niloofar Nikaein..et al. Immune digital twins for complex human pathologies: applications, limitations, and challenges. NPJ Syst Biol Appl. 2024 Nov 30;10(1):141.

Salihovic, S., Eklund, D., Kruse, R. et al. Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance. Metabolomics 20, 111 (2024).

Herring M, Persson A, Potter R, Karlsson R, Särndahl E, Ejdebäck M: Exposing kinetic disparities between inflammasome readouts using time-resolved analysis. Heliyon, 2024, June 10;11.

Persson A, Koivula T, Jacobsson S, Stenmark B: Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates. BMC Infect. Dis., 2024, March 24(286).

Andi Alijagic, Damir Suljević, Muhamed Fočak, Jasmina Sulejmanović, Elma Šehović, Eva Särndahl, Magnus Engwall. The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective. Environment International. 10 May 2024.  doi.org/10.1016/j.envint.2024.108736

Andi Alijagic, Eva Särndahl. Can evolutionary immunology decode micro and nanoplastic challenges? Front. Immunol. Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1404360

Alijagic A, Hedbrant A, Persson A, Larsson M, Engwall M, Särndahl E: NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Front. Immunol., 2023. April 18;14.

Hedbrant A, Engström C, Andersson L, Eklund D, Westberg H, Persson A, Särndahl E: Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease. Environ. Health, 2023 March 13;22(1):25

Andi Alijagic, Oleksandr Kotlyar, Maria Larsson, Samira Salihovic, Alexander Hedbrant, Ulrika Eriksson, Patrik Karlsson, Alexander Persson, Nikolai Scherbak, Kim Färnlund, Magnus Engwall, Eva Särndahl. Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environ Int 2023 Dec 29:183:108412, doi: 10.1016/j.envint.2023.108412

Andi Alijagic, Xuying Wang, Naga Vera Srikanth Vallabani, Pelle Melin, Eva Särndahl, Hanna L, Karlsson, Inger Odnevall. Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders.  Nano Select, doi.org/10.1002/nano.202300188

Flagship publication: Marcus Krantz, Daniel Eklund, Eva Särndahl, Alexander Hedbrant; X-HiDE Consortium. A detailed molecular network map and model of the NLRP3 inflammasome. Front. Immunol., 15 November 2023. doi .org/10.3389/fimmu.2023.1233680

Flagship publication: Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman; X-HiDE Consortium. Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation. J Biol Chem. 2023 Sep 1;105205. doi: 10.1016/j.jbc.2023.105205. Online ahead of print.

Kedeye Tuerxun, Daniel Eklund, Ulrika Wallgren, Katharina Dannenberg, Dirk Repsilber , Robert Kruse, Eva Särndahl, Lisa Kurland. Predicting sepsis using a combination of clinical information and molecular immune markers sampled in the ambulance. Sci Rep. 2023 Sep 10;13(1):14917.  doi: 10.1038/s41598-023-42081-6.

Lena Andersson, Alexander Hedbrant, Ing-Liss Bryngelsson, Per Vihlborg, Eva Särndahl, Håkan Westberg. Silica exposure and cardiovascular, cerebrovascular, and respiratory morbidity in a cohort of male Swedish iron foundry workers. J Occup Environ Med. 2023 Jun 12.  
doi: 10.1097/JOM.0000000000002890. Online ahead of print.

William Lövfors, Rasmus Magnusson, Cecilia Jönsson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman. A comprehensive mechanistic model of adipocyte signaling with layers of confidence. NPJ Syst Biol Appl . 2023 Jun 7;9(1):24. 
doi: 10.1038/s41540-023-00282-9.

Hylén U, Särndahl E, Bejerot S, Humble MB, Hyötyläinen T, Salihovic S, Eklund D.
Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders. BMC Psychiatry (2023) 23:268 https://doi.org/10.1186/s12888-023-04784-y

Alijagic A, Hedbrant A, Perssopn A, Larsson M, Engwall M, Särndahl E. NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Front. Immunol., 18 April 2023, Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1178434

Hedbrant A, Engström C, Andersson L, Eklund D, Westberg H, Persson A, Särndahl E.
Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease.
Environ Health. 2023. doi: 10.1186/s12940-023-00980-1.

Flagship publication: Tuerxun K, Midtbö K, Särndahl E, Vorontsov E, Karlsson R, Persson A, Kruse R, Eklund D; X-HiDE Consortium. Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1. J Leukoc Biol. 2022 Oct;112(4):679-692. doi: 10.1002/JLB.3A0421-216R. Epub 2022 Mar 13. PMID: 35285058

Tuerxun K, Midtbö K, Särndahl E, Vorontsov E, Karlsson R, Persson A, Kruse R, Eklund D: Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1. J. Leuk. Biol., 2022, October 112(4):679-692.

Hedbrant A, Eklund D, Andersson A, Bryngelsson I-L, Persson A, Westberg H, Särndahl E: Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry. Biomarkers, 2021, 27(1):60-70.

Nyman E, Lindh M, Lövfors W, Simonsson C, Persson A, Eklund D, Bäckström E, Fridén M, Cedersund G: Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modelling. CPT Pharmacometrics. Syst. Pharmacol. 2020, 9(12.

Midtbö K, Eklund D, Särndahl E, Persson A: Molecularly distinct NLRP3 inducers mediate diverse ratios of Interleukin-1β and Interleukin-18 from human monocytes. Med. Infl. 2020, October 22.