Modeling Inflammation
X-HiDE explores inflammation as a dynamic multi-level systems of regulatory interactions. The knowledge models gained in X-HiDE will provide insight into several diseases as they describe fundamental inflammatory processes.
By utilizing a systems-analytical approach, complex inflammatory responses are broken down into basic elements and interactions that are described mathematically. To make the best use of the rapidly growing amounts of data, multi-level mathematical models are needed, i.e. models that simultaneously capture multiple layers of the biological data. Process-models describe the most detailed level of modeling, where complex biological mechanisms are picked apart and then put back together piece by piece. By setting up mathematical descriptions of inflammatory mechanisms, using ordinary differential equations or constraint-based models, an explicit implementation of knowledge, as a dynamical in silico model, is built from biological data.
Conceptual example of how of smaller process-models will be described and create the foundation for inflammatory phenotypes.