Maria Hårdstedt
Position: Affiliated Researcher School/office: School of Medical SciencesEmail: bWFyaWEuaGFyZHN0ZWR0O29ydS5zZQ==
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About Maria Hårdstedt
Maria Hårdstedt is a researcher at the Center for Clinical Research (CKF) Dalarna and an affiliated researcher at Örebro and Uppsala universities. She is a specialist in internal medicine and a resident physician in general medicine at Vansbro Primary Care Center.
Background
Maria Hårdstedt completed her PhD in clinical immunology at Uppsala University in 2014 with a thesis titled "Studies of Innate and Adaptive Immunity in Islet Cell Transplantation." She started her PhD at the Department of Surgery, University of Minnesota in the USA. Maria holds two degrees - a medical degree from Karolinska Institutet and a bachelor's degree in biochemistry from Uppsala University.
Research Projects
Swimming-induced Pulmonary Edema (SIPE)
Maria is principal investigator for research on swimming-induced pulmonary edema (SIPE) at the Vansbrosimningen open water swimming event. Approximately 40 swimmers annually experience SIPE during the Vansbrosimningen and seek assistance at the on-site mobile medical unit. SIPE is characterized by sudden respiratory difficulties, coughing, mucus/blood from the airways, and reduced energy during swimming. SIPE is a relatively rare condition, and knowledge is lacking about risk factors, comorbidities, and the necessary treatment and follow-up for those affected. Vansbrosimningen provides a unique opportunity to study SIPE due to the simultaneous participation of a large number of swimmers.
The Breastfeeding Study – Factors Affecting Breastfeeding
This study takes a comprehensive approach to the reasons why some mothers experience breastfeeding problems and prematurely end breastfeeding. The study is a prospective, longitudinal cohort study with the aim of identifying factors that affect breastfeeding. The study is based at Dalarna University and is led by Jenny Ericson.
TIE Study (Tools Identifying Exacerbations in COPD)
The TIE study is a prospective cohort study in primary and specialist care where data has been collected for patients with COPD. The study is a collaboration between researchers in Region Dalarna, Uppsala, and Gävleborg. The main goal is to identify tools to predict low and high future risk of exacerbations, lung function decline, and mortality.
Research on Covid-19
During the Covid-19 pandemic, Maria, together with colleagues, initiated several research studies. These studies covered various areas during the early pandemic - diagnostics, infection control, and healthcare professionals' experiences of working during the critical onset of the pandemic.
Research groups
Publications
Articles in journals
- Lind, A. , Cao, Y. , Hesser, H. , Hårdstedt, M. , Jansson, S. P. O. , Lernmark, Å. , Sundqvist, M. , Tevell, S. & et al. (2024). Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19. Diabetes epidemiology and management, 13. [BibTeX]
- Skagerström, J. , Fernemark, H. , Nilsen, P. , Seing, I. , Hårdstedt, M. , Karlsson, E. & Schildmeijer, K. (2023). Challenges of primary health care leadership during the COVID-19 pandemic in Sweden: a qualitative study of managers' experiences. Leadership in Health Services, 36 (3), 389-401. [BibTeX]
- Hårdstedt, M. & Seiler, C. (2023). Swimming-Induced Pulmonary Edema: Respiratory Pathogens as a Potential Risk Factor. Chest, 163 (5). [BibTeX]
- Kristiansson, L. , Seiler, C. , Lundeqvist, D. , Braman Eriksson, A. , Sundh, J. & Hårdstedt, M. (2023). Symptom duration, recurrence and long-term effects of swimming-induced pulmonary edema: a 30-month follow-up study. Chest, 164 (5), 1257-1267. [BibTeX]
- Seiler, C. & Hårdstedt, M. (2022). Response. Chest, 162 (2), e109-e109. [BibTeX]
- Seiler, C. , Kristiansson, L. , Klingberg, C. , Sundh, J. , Eriksson, A. B. , Lundeqvist, D. , Nilsson, K. F. & Hårdstedt, M. (2022). Swimming-induced pulmonary edema: evaluation of prehospital treatment with continuous positive airway pressure or positive expiratory pressure device. Chest, 162 (2), 410-420. [BibTeX]
- Mathabire Rücker, S. C. , Gustavsson, C. , Rücker, F. , Lindblom, A. & Hårdstedt, M. (2022). Transmission of COVID-19 among healthcare workers: an epidemiological study during the first phase of the pandemic in Sweden. Epidemiology and Infection, 150. [BibTeX]
- Fernemark, H. , Skagerstrom, J. , Seing, I. , Hårdstedt, M. , Schildmeijer, K. & Nilsen, P. (2022). Working conditions in primary healthcare during the COVID-19 pandemic: an interview study with physicians in Sweden. BMJ Open, 12 (2). [BibTeX]
- Rücker, F. , Hårdstedt, M. , Rücker, S. C. M. , Aspelin, E. , Smirnoff, A. , Lindblom, A. & Gustavsson, C. (2021). From chaos to control - experiences of healthcare workers during the early phase of the COVID-19 pandemic: a focus group study. BMC Health Services Research, 21 (1). [BibTeX]
- Hårdstedt, M. , Kristiansson, L. , Seiler, C. , Eriksson, A. B. & Sundh, J. (2021). Incidence of swimming-induced pulmonary edema (SIPE): a cohort study based on 47,600 open-water swimming distances. Chest, 160 (5), 1789-1798. [BibTeX]
- Seiler, C. , Klingberg, C. & Hårdstedt, M. (2021). Lung Ultrasound for Identification of Patients Requiring Invasive Mechanical Ventilation in COVID-19.. Journal of ultrasound in medicine, 40 (11), 2339-2351. [BibTeX]
- Hårdstedt, M. , Seiler, C. , Kristiansson, L. , Lundeqvist, D. , Klingberg, C. & Braman Eriksson, A. (2020). Swimming-Induced Pulmonary Edema: Diagnostic Criteria Validated by Lung Ultrasound. Chest, 158 (4), 1586-1595. [BibTeX]
- Silfverberg, T. , Sahlander, F. , Enlund, M. , Oscarson, M. & Hårdstedt, M. (2018). Late onset hyperornithinemia-hyperammonemia-homocitrullinuria syndrome: how web searching by the family solved unexplained unconsciousness: a case report. Journal of Medical Case Reports, 12 (1). [BibTeX]
- Braman Eriksson, A. , Annsberg, M. & Hårdstedt, M. (2017). Simningsorsakat lungödem vid svenska förhållanden otillräckligt studerat: erfarenheter från Vansbrosimningen 2016: [Swimming-induced pulmonary edema in Swedish conditions has been insufficiently studied]. Läkartidningen, 114 (25-26). [BibTeX]
- Hårdstedt, M. , Lindblom, S. , Karlsson-Para, A. , Nilsson, B. & Korsgren, O. (2016). Characterization of innate immunity in an extended whole blood model of human islet allotransplantation. Cell Transplantation, 25 (3), 503-515. [BibTeX]
- Hårdstedt, M. , Lindblom, S. , Hong, J. , Nilsson, B. , Korsgren, O. & Ronquist, G. (2015). A novel model for studies of blood-mediated long-term responses to cellular transplants. Upsala Journal of Medical Sciences, 120 (1), 28-39. [BibTeX]
- Dvorak, C. , Hårdstedt, M. , Xie, H. , Wang, M. , Papas, K. , Hering, B. J. , Murtaugh, M. & Fahrenkrug, S. (2007). Transcriptional profiling of stress response in cultured porcine islets. Biochemical and Biophysical Research Communications - BBRC, 357 (1), 118-125. [BibTeX]
- Hering, B. J. , Wijkstrom, M. , Graham, M. L. , Hårdstedt, M. , Aasheim, T. C. , Jie, T. , Ansite, J. D. , Nakano, M. & et al. (2006). Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nature Medicine, 12 (3), 301-303. [BibTeX]
- Hårdstedt, M. , Finnegan, C. P. , Kirchhof, N. , Hyland, K. A. , Wijkstrom, M. , Murtaugh, M. P. & Hering, B. J. (2005). Post‐transplant upregulation of chemokine messenger RNA in non‐human primate recipients of intraportal pig islet xenografts. Xenotransplantation, 12 (4), 293-302. [BibTeX]
- Chavers, B. M. , Hårdstedt, M. & Gillingham, K. J. (2003). Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine. Pediatric nephrology (Berlin, West), 18 (6), 565-569. [BibTeX]
Conference papers
- Gonzalez Lindh, M. , Ställberg, B. , Hårdstedt, M. , Malinovschi, A. , Bröms, K. , Lisspers, K. , Palm, A. , Janson, C. & et al. (2022). Subjective swallowing symptoms in COPD - a 2-year follow up: a 2-year follow up. Paper presented at ERS (European Respiratory Society), Barcelona, Spain, Sept 2022. [BibTeX]
Doctoral theses, comprehensive summaries
- Hårdstedt, M. (2014). Studies of Innate and Adaptive Immunity in Islet Transplantation. (Doctoral dissertation). (Comprehensive summary) Uppsala: Acta Universitatis Upsaliensis. [BibTeX]