Manon Fallet
Position: Researcher School/office: School of Science and TechnologyEmail: bWFub24uZmFsbGV0O29ydS5zZQ==
Phone: No number available
Room: B3116
About Manon Fallet
Manon Fallet is a researcher specializing in environmental epigenetics at Örebro University (ORU) in Sweden. Her research delves into the molecular mechanisms, particularly focusing on epigenetics, underlying organisms’ response to environmental and transgenerational impacts, with implications for adaptation and evolution. She possesses a strong background in molecular biology, evolution, and ecology, defending her PhD at the University of Perpignan Via Domitia, France in 2019, where she explored the environmental and immune responses of Crassostrea gigas to various stressors (main publication: Fallet et al, 2022).
Following her doctoral studies, Manon pursued her postdoctoral research at Örebro University, investigating the transgenerational response of zebrafish to PFAS (2020-2022) (Fallet et al, 2024) and later at the University of Oxford, studying epimutations and gene expression changes in lines of C. elegans exposed to cisplatin (Fallet et al, 2023).
Research description
Manon's research integrates physiology, embryology, behavioral tests, molecular biology, multi-omics analysis, and bioinformatics. In her project EpiClim, she uses zebrafish to study the transgenerational impact of climate change, PFOS, and their combined effects. This research investigates the physiologic, transcriptomic, epigenetic, and microbiota influences on zebrafish, exploring how these effects are transmitted to future generations.
Aiming to uncover how molecular interplay shapes adaptation, Manon's work offers insights into the intricate relationships between environmental changes and molecular responses, facilitating efforts to conserve vulnerable species. Additionally, her research contributes to understanding how environmental factors impact gene expression and physiology across generations, providing new perspectives on stress susceptibility, health outcomes, and prevention strategies.
Manon's academic potential and contributions have been recognized through a PhD fellowship at ED305, University of Perpignan Via Domitia (2016-2019), and the FORMAS Early Career Grant - starting grant (4M SEK 2023-2027).
Teaching and science valorization
Manon is actively involved in teaching through several bachelor and master courses, including Food Microbiology (course coordinator), Developmental Biology, Cell Biology, and Biological Forensics at the School of Science and Technology at ORU. She also draws from previous experience in teaching Genetics and Animal Physiology at the University of Perpignan Via Domitia.
In addition to her research and teaching activities, Manon is convinced of the importance of science popularisation. She is engaged in various science communication events, such as Pint of Science, Sweden, where she holds the position of city coordinator for Örebro.
Education
2022-2023: Postdoctoral researcher, University of Oxford, Oxford, United Kingdom.
2022-2020: Postdoctoral researcher, Örebro University, Örebro, Sweden. EpiTrans/EpiTemp/EpiTag projects.
2016-2019: PhD in Molecular Biology, University of Perpignan Via Domitia, Perpignan, France, Transgigas project.
2015-2016: MSc in Biodiversity, Ecology, and Evolution, specializing in "Biodiversity and Sustainable Development", University of Perpignan Via Domitia, Perpignan, France.
2013-2015: MSc in Biodiversity, Ecology, and Evolution, University Toulouse III - Paul Sabatier, Toulouse, France.
2012-2013: BSc in Biology of Organisms, Populations, and Ecosystems, University Blaise Pascal, Clermont-Ferrand, France.
2010-2012: Two-year University Diploma of Technology in Biological and Environmental Engineering, IUT of Saint-Etienne, Jean Monnet University, Saint-Etienne, France.
Research projects
Active projects
Research groups
Publications
Articles in journals
- Fallet, M. , Wilson, R. & Sarkies, P. (2023). Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans. BMC Biology, 21 (1). [BibTeX]
- Fallet, M. , Montagnani, C. , Petton, B. , Dantan, L. , de Lorgeril, J. , Comarmond, S. , Chaparro, C. , Toulza, E. & et al. (2022). Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection. Microbiome, 10 (1). [BibTeX]
- Vacher, J. , Kok, P. J. , Rodrigues, M. T. , Lima, J. D. , Lorenzini, A. , Martinez, Q. , Fallet, M. , Courtois, E. A. & et al. (2017). Cryptic diversity in Amazonian frogs: Integrative taxonomy of the genus Anomaloglossus (Amphibia: Anura: Aromobatidae) reveals a unique case of diversification within the Guiana Shield. Molecular Phylogenetics and Evolution, 112, 158-173. [BibTeX]
- Rondon, R. , Grunau, C. , Fallet, M. , Charlemagne, N. , Sussarellu, R. , Chaparro, C. , Montagnani, C. , Mitta, G. & et al. (2017). Effects of a parental exposure to diuron on Pacific oyster spat methylome. Environmental Epigenetics, 3 (1). [BibTeX]
Articles, reviews/surveys
- Zetzsche, J. & Fallet, M. (2024). To live or let die? Epigenetic adaptations to climate change-a review. Environmental epigenetics, 10 (1). [BibTeX]
- Fallet, M. , Blanc, M. , Di Criscio, M. , Antczak, P. , Engwall, M. , Guerrero Bosagna, C. , Rüegg, J. & Keiter, S. (2023). Present and future challenges for the investigation of transgenerational epigenetic inheritance. Environment International, 172. [BibTeX]
- Fallet, M. , Luquet, E. , David, P. & Cosseau, C. (2020). Epigenetic inheritance and intergenerational effects in mollusks. Gene, 729. [BibTeX]
Chapters in books
- Fallet, M. (2024). Epigenetic Inheritance. In: Guenther Witzany, Epigenetics in Biological Communication (pp. 87-130). . Springer. [BibTeX]
- Fallet, M. (2023). Epigenetics in Mollusks. In: Francesc Piferrer; Han-Ping Wang, Epigenetics in Aquaculture (pp. 325-354). Hoboken, New Jersey, United States: John Wiley & Sons. [BibTeX]