Magnus Grenegård

Articles in journals

• Zegeye, M. M. , Matic, L. , Lengquist, M. , Hayderi, A. , Grenegård, M. , Hedin, U. , Sirsjö, A. , Ljungberg, L. U. & et al. (2023). Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells. Atherosclerosis, 371, 41-53.
• Wenglén, C. , Demirel, I. , Göthlin Eremo, A. , Grenegård, M. & Paramel Varghese, G. (2023). Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells. European Journal of Pharmacology, 944.
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Dynamic Changes in Pentraxin-3 and Neprilysin in ST Segment Elevation Myocardial Infarction. Biomedicines, 10 (2).
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Levels of soluble tumor necrosis factor receptor 1 and 2 are associated with survival after ST segment elevation myocardial infarction. Scientific Reports, 12 (1).
• Paramel Varghese, G. , Lindkvist, M. , Idosa, B. A. , Sebina, L. S. , Kardeby, C. , Fotopoulou, T. , Pournara, D. , Kritsi, E. & et al. (2022). Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells. European Journal of Pharmacology, 929.
• Lindkvist, M. , Zegeye, M. M. , Grenegård, M. & Ljungberg, L. (2022). Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells. International Journal of Molecular Sciences, 23 (3).
• Lunde, N. N. , Gregersen, I. , Ueland, T. , Shetelig, C. , Holm, S. , Kong, X. Y. , Michelsen, A. E. , Otterdal, K. & et al. (2020). Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages. Atherosclerosis, 296, 74-82.
• Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. (2019). A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. European Journal of Pharmacology, 857.
• Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α_2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cellular Signalling, 59, 96-109.
• Befekadu, R. , Christiansen, K. , Larsson, A. & Grenegård, M. (2019). Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction. Cardiology Journal, 26 (4), 385-393.
• Lindkvist, M. , Fernberg, U. , Ljungberg, L. , Fälker, K. , Fernström, M. , Hurtig-Wennlöf, A. & Grenegård, M. (2019). Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults. Thrombosis Research, 174, 5-12.
• Kardeby, C. , Fälker, K. , Haining, E. J. , Criel, M. , Lindkvist, M. , Barroso, R. , Påhlsson, P. , Ljungberg, L. & et al. (2019). Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. Blood Advances, 3 (3), 275-287.
• Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1).
• Tengdelius, M. , Kardeby, C. , Fälker, K. , Griffith, M. , Påhlsson, P. , Konradsson, P. & Grenegård, M. (2017). Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets. Macromolecular Bioscience, 17 (2).
• Donner, L. , Fälker, K. , Gremer, L. , Klinker, S. , Pagani, G. , Ljungberg, L. U. , Lothmann, K. , Rizzi, F. & et al. (2016). Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Science Signaling, 9 (429).
• Sodergren, A. L. , Holm, A. B. S. , Ramström, S. , Lindström, E. G. , Grenegård, M. & Öllinger, K. (2016). Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances. Platelets, 27 (1), 86-92.
• Holm, A. B. S. , Grenegård, M. , Ollinger, K. & Lindström, E. G. (2014). Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function. Platelets, 25 (2), 111-117.
• Tengdelius, M. , Lee, C. , Grenegård, M. , Griffith, M. , Påhlsson, P. & Konradsson, P. (2014). Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization. Biomacromolecules, 15 (7), 2359-2368.
• Peng, X. , Ramström, S. , Kurz, T. , Grenegård, M. & Segelmark, M. (2014). The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca2+ signaling pathways. Thrombosis Research, 134 (2), 418-425.
• Fälker, K. , Klarström-Engström, K. , Bengtsson, T. , Lindahl, T. L. & Grenegård, M. (2014). The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLC gamma 2 signalling cascade. Cellular Signalling, 26 (2), 279-286.
• Boknäs, N. , Faxälv, L. , Sanchez Cenellas, D. , Wallstedt, M. , Ramström, S. , Grenegård, M. & Lindahl, T. L. (2014). Thrombin-induced platelet activation via PAR4: pivotal role for exosite II. Thrombosis and Haemostasis, 112 (3), 558-565.
• Junker, J. P. , Lönnqvist, S. , Rakar, J. , Karlsson, L. K. , Grenegård, M. & Kratz, G. (2013). Differentiation of human dermal fibroblasts towards endothelial cells. Differentiation, 85 (3), 67-77.
• Elvers, M. , Grenegård, M. , Khoshjabinzadeh, H. , Münzer, P. , Borst, O. , Tian, H. , Di Paolo, G. , Lang, F. & et al. (2012). A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity. Cellular Signalling, 24 (9), 1743-52.
• Kälvegren, H. , Skoglund, C. , Helldahl, C. , Lerm, M. , Grenegård, M. & Bengtsson, T. (2010). Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X(1)-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y(1) and P2Y(12) receptor activation. Thrombosis and Haemostasis, 103 (2), 398-407.
• Kälvegren, H. , Andersson, J. , Grenegård, M. & Bengtsson, T. (2007). Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. European Journal of Pharmacology, 566 (1-3), 20-27.

Books

• Venizelos, N. , Sirsjö, A. , Grenegård, M. , Karlsson, M. , Andersson, S. , Hjelmqvist, H. , Ericsson, E. , Kihlgren, A. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) , Karlsson, M. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Ericsson, E. (ed.) , Kihlgren, A. (ed.) & Söderquist, B. (ed.) (2016). Örebro University’s Nobel Day Festivities: Book of abstracts, 2016. Örebro: Örebro universitet.
• Venizelos, N. , Sirsjö, A. , Grenegård, M. & Karlsson, M. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) & Karlsson, M. (ed.) (2015). Örebro University’s Nobel Day Festivities: Book of abstracts 2015. Örebro: Örebro universitet.
• Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Kihlgren, A. , Grenegård, M. , Möller, C. , Danermark, B. , Eriksson, C. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Kihlgren, A. (ed.) , Grenegård, M. (ed.) , Möller, C. (ed.) , Danermark, B. (ed.) , Eriksson, C. (ed.) , Ericsson, C. (ed.) & Kadi, F. (ed.) (2014). Örebro University’s Nobel Day Festivities: Book of abstracts 2014. Örebro: Örebro universitet.
• Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Nilsson, U. , Grenegård, M. , Eriksson, C. & Ericsson, C. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Nilsson, U. (ed.) , Grenegård, M. (ed.) , Eriksson, C. (ed.) & Ericsson, C. (ed.) (2013). Örebro University’s Nobel Day Festivities: Book of abstracts 2013. Örebro: Örebro universitet.

Conference papers

• Grenegård, M. , Koufaki, M. , Zervou, M. , Fotopoulou, T. , Lindström, E. , Nilsson, K. F. , Lindkvist, M. & Fransén, K. (2023). The cardioprotective, anti-inflammatory and antithrombotic piperazinyl-purine analogue MK177 is a bifunctional drug with promising therapeutic potential. In:  British Journal of Pharmacology. Macmillan Publishers Ltd..

Manuscripts

• Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. , Nilsson, B. & Ramström, S. Activation of the lectin complement pathway during and after ST segment elevation myocardial infarction.
• Lindkvist, M. , Zegeye, M. M. , Sirsjö, A. , Grenegård, M. & Ljungberg, L. U. Comparative evaluation of gp130 signalling cytokines in human endothelial cells : evidence for both specific and overlapping molecular responses.
• Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets.
• Kardeby, C. , Sirsjö, A. , Ljungberg, L. & Grenegård, M. Sulfated glycopolymers and polysaccharides regulate inflammation-related proteins in human vascular endothelial cells.