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Julia König

Position: Senior Lecturer School/office: School of Medical Sciences

Email: anVsaWEua29uaWc7b3J1LnNl

Phone: +46 19 303645

Room: X2106

Research subject

Medicine

Research environments

Nutrition-Gut-Brain Interactions Research Centre (NGBI)
Responsive Nutrition Research Centre

About Julia König

Julia König is a senior lecturer and associate professor (docent) at the School of Medical Sciences. She joined the NGBI research centre as a postdoctoral researcher in December 2012. She received a Master’s degree in nutrition science in 2008 from the University of Hohenheim in Germany and graduated from the international PhD program ‘Molecular Medicine’ from the Medical University of Graz, Austria in 2011. The topic of her PhD thesis was ‘Endothelial differentiation potential of amnion-derived mesenchymal stromal cells’, in which she investigated a potential therapeutic use of human placenta-derived cells in vascular biology. After her PhD, she worked as a postdoctoral researcher for the Department of Obstetrics and Gynaecology at the Medical University of Graz for the project ‘Detection of biomarkers for preterm birth in saliva and cervico-vaginal fluid of pregnant women using proteomics’.

As part of the NGBI group, she is combining her background in nutrition science with her interest in translational clinical research. With her research she is investigating the interactions between nutrition, gut microbiota, the gut and the brain, and tries to find new treatments for gastrointestinal disorders such as irritable bowel syndrome (IBS).

Active projects

Completed projects

Research groups

Nutrition Gut Brain Axis

Publications

Articles in journals

Roca Rubio, M. F. , Folkesson, M. , Kremp, C. , Evertsson, N. , Repsilber, D. , Eriksson, U. , Ganda Mall, J. P. , Kadi, F. & et al. (2024). Associations between various markers of intestinal barrier and immune function after a high-intensity exercise challenge. Physiological Reports, 12 (10). [BibTeX]
Rode, J. , Brengesjö Johnson, L. , König, J. , Rangel, I. , Engstrand, L. , Repsilber, D. & Brummer, R. J. (2024). Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota. Gut microbes, 16 (1). [BibTeX]
König, J. , Roca Rubio, M. F. , Forsgård, R. A. , Rode, J. , Axelsson, J. , Grompone, G. & Brummer, R. J. (2024). The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT. PLOS ONE, 19 (11). [BibTeX]
Rode, J. , Edebol Carlman, H. M. T. , König, J. , Hutchinson, A. , Thunberg, P. , Persson, J. & Brummer, R. J. (2022). Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT. Cells, 11 (18). [BibTeX]
Edebol Carlman, H. M. T. , Rode, J. , König, J. , Repsilber, D. , Hutchinson, A. , Thunberg, P. , Persson, J. , Kiselev, A. & et al. (2022). Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses to an Arithmetic Stress Task in Healthy Subjects: A Randomised Clinical Trial and Proof-of-Concept Study. Nutrients, 14 (7). [BibTeX]
Rode, J. , Edebol Carlman, H. M. T. , König, J. , Repsilber, D. , Hutchinson, A. , Thunberg, P. , Andersson, P. , Persson, J. & et al. (2022). Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial. Frontiers in nutrition, 9. [BibTeX]
Rode, J. , Yang, L. , König, J. , Hutchinson, A. , Wall, R. , Venizelos, N. , Brummer, R. J. , Rangel, I. & et al. (2021). Butyrate Rescues Oxidative Stress-Induced Transport Deficits of Tryptophan: Potential Implication in Affective or Gut-Brain Axis Disorders. Neuropsychobiology, 80 (3), 253-263. [BibTeX]
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , de Vos, W. M. & et al. (2021). Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. Beneficial Microbes, 12 (1), 17-30. [BibTeX]
Roca Rubio, M. F. , Eriksson, U. , Brummer, R. J. & König, J. (2021). Sauna dehydration as a new physiological challenge model for intestinal barrier function. Scientific Reports, 11 (1). [BibTeX]
Roca Rubio, M. F. , Eriksson, U. , Brummer, R. J. & König, J. (2021). Short intense psychological stress induced by skydiving does not impair intestinal barrier function. PLOS ONE, 16 (7). [BibTeX]
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Veress, G. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. (2020). Faecal microbiota transfer in patients with microscopic colitis: a pilot study in collagenous colitis. Scandinavian Journal of Gastroenterology, 55 (12), 1454-1466. [BibTeX]
König, J. & Brummer, R. J. (2020). Faecal microbiota transplantation in IBS: new evidence for success?. Nature Reviews. Gastroenterology & Hepatology, 17 (4), 199-200. [BibTeX]
Holster, S. , Hooiveld, G. J. , Repsilber, D. , de Vos, W. , Brummer, R. J. & König, J. (2019). Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome. Biomolecules, 9 (10). [BibTeX]
Holster, S. , Lindqvist, C. M. , Repsilber, D. , Salonen, A. , de Vos, W. , König, J. & Brummer, R. J. (2019). The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study. Clinical and Translational Gastroenterology, 10 (4). [BibTeX]
König, J. & Brummer, R. J. (2018). Is an enzyme supplement for celiac disease finally on the cards?. Expert Review of Gastroenterology & Hepatology, 12 (6), 531-533. [BibTeX]
König, J. , Holster, S. , Maaike, B. & Brummer, R. J. (2017). Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting. Scientific Reports, 7 (13100). [BibTeX]
König, J. , Lang, I. , Siwetz, M. , Fröhlich, J. & Huppertz, B. (2014). Amnion-derived mesenchymal stromal cells show a mesenchymal-epithelial phenotype in culture.. Cell and Tissue Banking, 15 (2), 193-198. [BibTeX]
Kinzer, M. , Hingerl, K. , König, J. , Reinisch, A. , Strunk, D. , Huppertz, B. & Lang, I. (2014). Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.. Placenta, 35 (7), 517-519. [BibTeX]
König, J. , Weiss, G. , Rossi, D. , Wankhammer, K. , Reinisch, A. , Kinzer, M. , Huppertz, B. , Pfeiffer, D. & et al. (2014). Placental Mesenchymal Stromal Cells Derived from Blood Vessels or Avascular Tissues: What Is the Better Choice to Support Endothelial Cell Function?. Stem Cells and Development, 24 (1), 115-131. [BibTeX]
König, J. , Huppertz, B. , Desoye, G. , Parolini, O. , Fröhlich, J. D. , Weiss, G. , Dohr, G. , Sedlmayr, P. & et al. (2012). Amnion-derived mesenchymal stromal cells show angiogenic properties but resist differentiation into mature endothelial cells. Stem Cells and Development, 21 (8), 1309-1320. [BibTeX]
Fröhlich, J. D. , Huppertz, B. , Abuja, P. M. , König, J. & Desoye, G. (2012). Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia. American Journal of Pathology, 180 (1), 153-164. [BibTeX]
Huppertz, B. , Gauster, M. , Orendi, K. , König, J. & Moser, G. (2009). Oxygen as modulator of trophoblast invasion. Journal of Anatomy, 215 (1), 14-20. [BibTeX]

Articles, reviews/surveys

Halkjær, S. I. , Lo, B. , Cold, F. , Højer Christensen, A. , Holster, S. , König, J. , Brummer, R. J. , Aroniadis, O. C. & et al. (2023). Fecal microbiota transplantation for the treatment of irritable bowel syndrome: A systematic review and meta-analysis. World Journal of Gastroenterology, 29 (20), 3185-3202. [BibTeX]
König, J. , Siebenhaar, A. , Högenauer, C. , Arkkila, P. , Nieuwdorp, M. , Norén, T. , Ponsioen, C. Y. , Rosien, U. & et al. (2017). Consensus report: Faecal microbiota transfer - clinical applications and procedures. Alimentary Pharmacology and Therapeutics, 45 (2), 222-239. [BibTeX]
König, J. , Wells, J. , Cani, P. D. , García-Ródenas, C. L. , MacDonald, T. , Mercenier, A. , Whyte, J. , Troost, F. & et al. (2016). Human Intestinal Barrier Function in Health and Disease. Clinical and Translational Gastroenterology, 7 (10). [BibTeX]
König, J. & Brummer, R. (2014). Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. Beneficial Microbes, 5 (3), 247-261. [BibTeX]
König, J. , Rangel, I. & Brummer, R. J. (2013). The Role of Lactic Acid Bacteria in the Pathophysiology and Treatment of Irritable Bowel Syndrome (IBS). Food and Nutrition Sciences, 4 (11), 27-39. [BibTeX]

Chapters in books

Marques, T. M. , Holster, S. , Wall, R. , König, J. & Brummer, R. J. (2016). Correlating the gut microbiome to health and disease. In: Niall Hyland, Catherine Stanton, The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (pp. 261-291). . Elsevier. [BibTeX]
König, J. , Ganda-Mall, J. , Rangel, I. , Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. In: Koen Venema & Ana Paula do Carmo, Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press. [BibTeX]
König, J. & Brummer, R. (2014). Modulation of the gut ecosystem in irritable bowel syndrome. In: Gert Folkerts, Johan Garssen, Pharma-Nutrition: an overview (pp. 55-73). . Springer. [BibTeX]

Conference papers

Vumma, R. , Rode, J. , Yang, L. , Montero, J. , König, J. , Wall, R. , Hutchinson, A. , Venizelos, N. & et al. (2024). Exploring Therapeutic Strategies for Neuropsychiatric Disorders: Modulating Inflammation, Gut-Brain Interactions, and the Role of Butyrate. In: Journal of Pharmacology and Experimental Therapeutics. Paper presented at ASPET 2024 Annual Meeting - Neuropharmacology, Arlington, VA, USA, May 16-19, 2024. American Society for Pharmacology and Experimental. [BibTeX]
Edebol-Carlman, H. , Rode, J. , König, J. , Hutchinson, A. , Repsilber, D. , Kiselev, A. , Thunberg, P. , Lathrop Stern, L. & et al. (2019). Evaluating the effects of probiotic intake on brain activity during an emotional attention task and blood markers related to stress in healthy subjects. Paper presented at Mind, Mood & Microbes, 2nd International Conference on Microbiota-Gut-Brain Axis, Amsterdam, The Netherlands, 17-18 January, 2019. [BibTeX]
König, J. , Holster, S. , Bruins, M. & Brummer, R. J. (2017). Aspergillus Niger-Derived Enzyme Degrades Gluten in the Stomach of Gluten-Sensitive Subjects. In: Gastroenterology. Paper presented at Digestive Disease Week (DDW), Chicago, IL, USA, May 6-9, 2017. (pp. S481-S481). Saunders Elsevier. [BibTeX]
König, J. , Holster, S. , Bruins, M. & Brummer, R. J. (2017). Effective gluten degradation in non-coeliac gluten-sensitive subjects by Aspergillus Niger derived enzyme: A placebo-controlled randomized clinical trial. Paper presented at United European Gastroenterology (UEG) Week, Barcelona (Oct 28-Nov 1, 2017). (pp. A28- Sage Publications. [BibTeX]
Holster, S. , Repsilber, D. , Brummer, R. J. & König, J. (2017). Faecal microbiota transfer in irritable bowel syndrome: clinical outcomes of a randomised placebo-controlled trial. In: UEG Week 2017 Oral Presentations. Paper presented at United European Gastroenterology (UEG) Week, Barcelona, Spain, October 28 - November 1, 2017. (pp. A155-A156). Sage Publications. [BibTeX]
Holster, S. , Brummer, R. J. , Repsilber, D. & König, J. (2017). Fecal Microbiota Transplantation in Irritable Bowel Syndrome and a Randomized Placebo-Controlled Trial. In: 2017 DDW Abstracts. Paper presented at Digestive Disease Week (DDW), Chicago, IL, USA, May 6-9, 2017. (pp. S101-S102). Saunders Elsevier. [BibTeX]

Manuscripts

Roca Rubio, M. F. , Repsilber, D. , Kremp, C. , Folkesson, M. , Evertsson, N. , Ganda Mall, J. , Kadi, F. , Brummer, R. & et al. Associations between various markers of intestinal barrier and immune function after a high-intensity exercise challenge. [BibTeX]
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , De Vos, W. M. & et al. Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. [BibTeX]
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Lindqvist, C. M. , de Vos, W. , Brummer, R. J. & König, J. Faecal microbiota transfer in irritable bowel syndrome results inaltered correlations between the gut microbiota and its metabolites. [BibTeX]
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. Faecal microbiota transfer in patients with microscopic colitis : A proof-of-concept study in collagenous colitis. [BibTeX]
Roca Rubio, M. F. , Forsgård, R. A. , Rode, J. , Brummer, R. J. & König, J. Markers of intestinal barrier function in diarrhoea-predominant irritable bowel syndrome : Correlations and individual variations. [BibTeX]
Edebol-Carlman, H. , Rode, J. , König, J. , Repsilber, D. , Hutchinson, A. N. , Thunberg, P. , Persson, J. , Kiselev, A. & et al. Probiotic mixture containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum affects brain responses to an arithmetic stress task in healthy subjects : A randomized clinical trial. [BibTeX]
Rode, J. , Edebol-Carlman, H. , König, J. , Repsilber, D. , Hutchinson, A. N. , Thunberg, P. , Andersson, P. , Persson, J. & et al. Probiotic mixture containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum affects brain responses towards an emotional task in healthy subjects : A randomized clinical trial. [BibTeX]
Rode, J. , Edebol-Carlman, H. , König, J. , Hutchinson, A. N. , Repsilber, D. , Thunberg, P. , Persson, J. & Brummer, R. J. Probiotic mixture containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum affects resting state brain function in healthy subjects : A randomized clinical trial. [BibTeX]