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Eewa Nånberg

Position: Professor School/office: School of Health Sciences

Email: ZWV3YS5uYW5iZXJnO29ydS5zZQ==

Phone: +46 19 303945

Room: P1317

Research subject

Biomedicine

About Eewa Nånberg

About Eewa Nånberg

Eewa Nånberg is professor in Biomedical Laboratory Science, School of Health Sciences, at Örebro University, since 2018. Eewa Nånberg has a research background in Cell biology and cell signalling, Tumour biology, cellular responses to exposure to endocrine disrupting chemicals (EDCs) and more recently cellular signalling in inflammatory responses.

Research

Eewa Nånberg has over the years moved between different research questions and projects with a common denominator of cellular responses related to disease mechanisms orchstrated by tumour cells. The current main focus is on inflammatory responses in monocytes/macrophages and interaction with tumour cells and regulation of tumour development, NiMO,(1-methyl Nicotinamide-driven ImmunoMOdulation in glioblastoma (NiMO). A project run in collaboration with Sprint Bioscience within the strategic research profile X-HiDE where Eewa Nånberg since 2019 is PI for WP1, Experimental inflammatory models, (https://www.oru.se/var-profil/strategiska-forskningsprofiler/x-hide/).

The other research focus is on exposure of in vitro cultures of neuronal cells and monocytes for defined endocrine disrupting chemicals (phenols) and adverse effects on cellular regulation through the endocannabinoid system. The endocannabinoid system has important although far from well described regulatory effects on inflammatory cells and this project aims to identify primary targets for environmental phenol exposures in endocannabinoid-receptor signalling in relation to intreaction with regulatory mechanisms in tumour cells with neuroblastoma cells as an in vitro model.

Research groups
Publications

Research groups

Inflammatory Response and Infection Susceptibility Centre (iRiSC)

Publications

Articles in journals

Nikaein, N. , Tuerxun, K. , Cedersund, G. , Eklund, D. , Kruse, R. , Särndahl, E. , Nånberg, E. , Thonig, A. & et al. (2023). Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation. Journal of Biological Chemistry, 299 (10). [BibTeX]
Caporale, N. , Leemans, M. , Birgersson, L. , Germain, P. , Cheroni, C. , Borbély, G. , Engdahl, E. , Lindh, C. & et al. (2022). From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. Science, 375 (6582). [BibTeX]
Shu, H. , Jönsson, B. A. G. , Gennings, C. , Lindh, C. H. , Nånberg, E. & Bornehag, C. (2019). PVC flooring at home and uptake of phthalates in pregnant women. Indoor Air, 29 (1), 43-54. [BibTeX]
Shu, H. , Wikström, S. , Jönsson, B. A. G. , Lindh, C. H. , Svensson, Å. , Nånberg, E. & Bornehag, C. (2018). Prenatal phthalate exposure was associated with croup in Swedish infants. Acta Paediatrica, 107 (6), 1011-1019. [BibTeX]
Shu, H. , Jönsson, B. A. , Gennings, C. , Svensson, Å. , Nånberg, E. , Lindh, C. H. , Knutz, M. , Takaro, T. K. & et al. (2018). Temporal Trends of Phthalate Exposures during 2007-2010 in Swedish Pregnant Women. Journal of Exposure Science and Environmental Epidemiology, 28, 437-447. [BibTeX]
Fjæraa Alfredsson, C. , Rendel, F. , Liang, Q. , Sundström, B. E. & Nånberg, E. (2015). Altered sensitivity to ellagic acid in neuroblastoma cells undergoing differentiation with 12-0-tetradecanoylphorbol-13-acetate and all-trans retinoic acid. Biomedicine and Pharmacotherapy, 76, 39-45. [BibTeX]
Ma, P. , Liu, X. , Wu, J. , Yan, B. , Zhang, Y. , Lu, Y. , Wu, Y. , Liu, C. & et al. (2015). Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin. Scientific Reports, 5. [BibTeX]
Tang, J. , Yuan, Y. , Wei, C. , Liao, X. , Yuan, J. , Nånberg, E. , Zhang, Y. , Bornehag, C. & et al. (2015). Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice. Toxicology Research, 4 (4), 1006-1015. [BibTeX]
Fjæraa Alfredsson, C. , Ding, M. , Liang, Q. , Sundström, B. & Nånberg, E. (2014). Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells. Biomedicine and Pharmacotherapy, 68 (1), 129-135. [BibTeX]
Shu, H. , Jönsson, B. A. , Larsson, M. , Nånberg, E. & Bornehag, C. (2014). PVC flooring at home and development of asthma among young children in Sweden, a 10-year follow-up. Indoor Air, 24 (3), 227-235. [BibTeX]
Bölling, A. , Holme, J. , Bornehag, C. , Nygaard, U. C. , Bertelsen, R. , Nånberg, E. , Bodin, J. , Sakhi, A. K. & et al. (2013). Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?. EXCLI Journal: Experimental and Clinical Sciences, 12, 733-759. [BibTeX]
Guo, J. , Han, B. , Qin, L. , Li, B. , You, H. , Yang, J. , Liu, D. , Wei, C. & et al. (2012). Pulmonary toxicity and adjuvant effect of di-(2-exylhexyl) phthalate in ovalbumin-immunized BALB/c mice. PLOS ONE, 7 (6). [BibTeX]
Bornehag, C. , Moniruzzaman, S. , Larsson, M. , Lindström, C. B. , Hasselgren, M. , Bodin, A. , von Kobyletzkic, L. B. , Carlstedt, F. & et al. (2012). The SELMA study: a birth cohort study in Sweden following more than 2000 mother-child pairs. Paediatric and Perinatal Epidemiology, 26 (5), 456-467. [BibTeX]
Karlsson, S. , Nånberg, E. , Fjaeraa, C. & Wijkander, J. (2010). Ellagic acid inhibits lipopolysaccharide-induced expression of enzymes involved in the synthesis of prostaglandin E2 in human monocytes. British Journal of Nutrition, 103 (8), 1102-1109. [BibTeX]
Fjaeraa, C. & Nånberg, E. (2009). Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomedicine and Pharmacotherapy, 63 (4), 254-261. [BibTeX]
Olsson, A. & Nånberg, E. (2001). A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. Experimental Cell Research, 265 (1), 21-30. [BibTeX]
Söderholm, H. , Olsson, A. , Lavenius, E. , Rönnstrand, L. & Nånberg, E. (2001). Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF. Cellular Signalling, 13 (2), 95-104. [BibTeX]
Rosenmüller, T. , Rydh, K. & Nånberg, E. (2001). Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB. Journal of Cellular Physiology, 188 (3), 369-382. [BibTeX]
Olsson, A. , Vadhammar, K. & Nånberg, E. (2000). Activation and protein kinase C-dependent nuclear accumulation of ERK in differentiating human neuroblastoma cells. Experimental Cell Research, 256 (2), 454-467. [BibTeX]
Fagerström, S. , Påhlman, S. & Nånberg, E. (1998). Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. Journal of Biological Chemistry, 273 (4), 2336-2343. [BibTeX]
Fagerström, S. , Påhlman, S. , Gestblom, C. & Nånberg, E. (1996). Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells. Cell growth & differentiation, 7 (6), 775-785. [BibTeX]
Eriksson, A. , Nånberg, E. , Rönnstrand, L. , Engström, U. , Hellman, U. , Rupp, E. , Carpenter, G. , Heldin, C. & et al. (1995). Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors. Journal of Biological Chemistry, 270 (13), 7773-7781. [BibTeX]
Påhlman, S. , Hoehner, J. , Nånberg, E. , Hedborg, F. , Fagerström, S. , Gestblom, C. , Johansson, I. , Larsson, U. & et al. (1995). Differentiation and survival influences of growth factors in human neuroblastoma. European Journal of Cancer, 31A (4), 453-458. [BibTeX]
Parrow, V. , Fagerström, S. , Meyerson, G. , Nånberg, E. & Påhlman, S. (1995). Protein kinase C-alpha and -epsilon are enriched in growth cones of differentiating SH-SY5Y human neuroblastoma cells. Journal of Neuroscience Research, 41 (6), 782-791. [BibTeX]
Lavenius, E. , Gestblom, C. , Johansson, I. , Nånberg, E. & Påhlman, S. (1995). Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor. Cell growth & differentiation, 6, 727-736. [BibTeX]
Lavenius, E. , Parrow, V. , Nånberg, E. & Påhlman, S. (1994). Basic FGF and IGF-I promote differentiation of human SH-SY5Y neuroblastoma cells in culture. Growth Factors, 10 (1), 29-39. [BibTeX]
Arkhammar, P. , Juntti-Berggren, L. , Larsson, O. , Welsh, M. , Nånberg, E. , Sjöholm, A. , Köhler, M. & Berggren, P. O. (1994). Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels. Journal of Biological Chemistry, 269 (4), 2743-2749. [BibTeX]
Arvidsson, A. K. , Rupp, E. , Nånberg, E. , Downward, J. , Rönnstrand, L. , Wennström, S. , Schlessinger, J. , Heldin, C. H. & et al. (1994). Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Molecular and Cellular Biology, 14 (10), 6715-6726. [BibTeX]
Nånberg, E. & Westermark, B. (1993). Platelet-derived growth factor increases the turnover of GTP/GDP on Ras in permeabilized fibroblasts. Journal of Biological Chemistry, 268 (24), 18187-18194. [BibTeX]
Parrow, V. , Nånberg, E. , Heikkilä, J. , Hammerling, U. & Påhlman, S. (1992). Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells. Journal of Cellular Physiology, 152 (3), 536-544. [BibTeX]
Mehmet, H. , Nånberg, E. , Lehmann, W. , Murray, M. J. & Rozengurt, E. (1990). Early signals in the mitogenic response of Swiss 3T3 cells: a comparative study of purified PDGF homodimers. Growth Factors, 3 (2), 83-95. [BibTeX]
Nånberg, E. , Morris, C. , Higgins, T. , Vara, F. & Rozengurt, E. (1990). Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation. Journal of Cellular Physiology, 143 (2), 232-242. [BibTeX]
Rozengurt, E. , Erusalimsky, J. , Mehmet, H. , Morris, C. , Nånberg, E. & Sinnett-Smith, J. (1988). Signal transduction in mitogenesis: further evidence for multiple pathways. Cold Spring Harbor Symposia on Quantitative Biology, 53, 945-954. [BibTeX]
Nånberg, E. & Rozengurt, E. (1988). Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca²⁺ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin. EMBO Journal, 7 (9), 2741-2747. [BibTeX]
Nånberg, E. & Nedergaard, J. (1987). Alpha-1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent. Biochimica et Biophysica Acta, 930 (3), 438-445. [BibTeX]
Lopez-Rivas, A. , Mendoza, S. A. , Nånberg, E. , Sinnett-Smith, J. & Rozengurt, E. (1987). Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells. Proceedings of the National Academy of Sciences of the United States of America, 84 (16), 5768-5772. [BibTeX]
Zachary, I. , Millar, J. , Nånberg, E. , Higgins, T. & Rozengurt, E. (1987). Inhibition of bombesin-induced mitogenesis by pertussis toxin: Dissociation from phospholipase C pathway.. Biochemical and Biophysical Research Communications - BBRC, 146 (2), 456-463. [BibTeX]
Nånberg, E. & Putney, J. (1986). Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates. FEBS Letters, 195 (1-2), 319-322. [BibTeX]
Burgess, G. , Dooley, R. , McKinney, J. , Nånberg, E. & Putney, J. (1986). Further studies on the interactions between the calcium mobilization and cyclic AMP pathways in guinea pig hepatocytes. Molecular Pharmacology, 30 (4), 315-320. [BibTeX]
Connolly, E. , Nånberg, E. & Nedergaard, J. (1986). Norepinephrine-induced Na+ influx in brown adipocytes is cyclic AMP-mediated. Journal of Biological Chemistry, 261 (31), 14377-14385. [BibTeX]
Nånberg, E. , Connolly, E. & Nedergaard, J. (1985). Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of alpha-1-adrenergic stimulation. Biochimica et Biophysica Acta, 844 (1), 42-49. [BibTeX]
Nedergaard, J. , Connolly, E. , Nånberg, E. & Mohell, N. (1984). A possible physiological role of the Na+/Ca2+ exchange mechanism of brown-fat mitochondria in the mediation of alpha-1-adrenergic signals. Biochemical Society Transactions, 12 (3), 393-396. [BibTeX]
Nånberg, E. , Nedergaard, J. & Cannon, B. (1984). Alpha-adrenergic effects on 86Rb+(K+) potentials and fluxes in brown fat cells. Biochimica et Biophysica Acta, 804 (3), 291-300. [BibTeX]
Connolly, E. , Nånberg, E. & Nedergaard, J. (1984). Na+-dependent, alpha-adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes. European Journal of Biochemistry, 141 (1), 187-193. [BibTeX]

Articles, reviews/surveys

Bornehag, C. & Nanberg, E. (2010). Phthalate exposure and asthma in children. International Journal of Andrology, 33 (2), 333-345. [BibTeX]

Conference papers

Shu, H. , Jönsson, B. A. , Lindh, C. H. , Knutz, M. , Nånberg, E. , Svensson, Å. & Bornehag, C. G. (2014). PVC flooring in the home is related to urinary levels of phthalates in swedish pregnant women in the SELMA study. In: Proceedings, Indoor Air 2014, Hong Kong. Paper presented at Conference of 13th International Conference on Indoor Air Quality and Climate (Indoor Air 2014), Hong Kong, July 7-12 2014. International Society of Indoor Air Quality and Climate. [BibTeX]
Shu, H. , Jönsson, B. A. , Larsson, M. , Nånberg, E. , Svensson, Å. & Bornehag, C. (2013). Description of 1st trimester urinary levels of phthalate and phenol metabolites in 2,356 Swedish women in the SELMA study. In: Journal of Environmental Health Perspectives. Paper presented at Environment and Health — Bridging South, North, East and West (with ISES and ISIAQ), Basel, Switzerland, 19–23 August 2013. National Institute of Environmental Health Science. [BibTeX]

Doctoral theses, comprehensive summaries

Nånberg, E. (1986). Adrenergic ionic fluxes in brown adipocytes. (Doctoral dissertation). (Comprehensive summary) Stockholm: Stockholm University. [BibTeX]

Manuscripts

Fjæraa Alfredsson, C. , Rendel, F. , Sundström, B. E. & Nånberg, E. Proliferation in morphologically differentiated SH-SY5Y human neuroblastoma cells. [BibTeX]